Basic Information

Insect: Drosophila picticornis
Gene Symbol: ZFX
Assembly: GCA_035043845.1
Location: JAWNMR010000493.1:5079155-5080419[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 7.4e-08 4.6e-06 26.7 0.5 3 23 207 228 206 228 0.96

2 6 0.00049 0.03 14.7 2.0 1 23 236 259 236 259 0.97

3 6 3.3e-05 0.002 18.4 0.1 1 23 265 287 265 287 0.97

4 6 8.3e-06 0.00051 20.2 1.3 1 23 296 318 296 318 0.98

5 6 5e-05 0.0031 17.8 4.8 1 23 327 349 327 349 0.98

6 6 2.2e-06 0.00013 22.1 0.8 1 23 355 378 355 378 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	7.4e-08	4.6e-06	26.7	0.5	3	23	207	228	206	228	0.96
2	6	0.00049	0.03	14.7	2.0	1	23	236	259	236	259	0.97
3	6	3.3e-05	0.002	18.4	0.1	1	23	265	287	265	287	0.97
4	6	8.3e-06	0.00051	20.2	1.3	1	23	296	318	296	318	0.98
5	6	5e-05	0.0031	17.8	4.8	1	23	327	349	327	349	0.98
6	6	2.2e-06	0.00013	22.1	0.8	1	23	355	378	355	378	0.97

Sequence Information

Coding Sequence: ATGTTCCCGCTGCTGTTGAACCGCACCGTTTTCGTTGTCTGCCGCTGCTGTCTGGTGGAGCAGCCGACGCTCTGCCACAGCATCGGTGACAACCAGCCATTGAGCATCGAGCTGCTGGAGTTGGTGCCCAATCTGGAGATCAAGCCCAGCGATGTCATCTGTCAGCTGTGCCTGCATCGTCTGCGCGACGCTCTCGAGTTCCGGCAACGCTGCCAGGACTCGGAGCGCATTCTGCGCGCCCGCCACGAACAGGCCCTGGATGATGCCCTCGAGTGTCTGGAGCGGGAAGTTGGTTGTCTGGAACAGGCCAAATCCACGTCCATGTCATCGCTAGTCGATCCCGTTGATTTCGGCACCTTGGATCTGTCCGATACATTTGAGAGCGGCTATGAACCAACAAACCGGACAACATCCTCCGTTAGCTGGGACTCGGGCATACTGAACACGCCTATCCATTTGCCAGCCTCGCTGGAACAgctggaacaacaacaacaacaacagcagcagcaaagcaacaCAATTGAAAGACCCATGGATACCAAACCCAAGCGGAAGCGATCACCACGGAaagctgtggcagctgtgccTCGGAGTAGGCCGCACAAATCGCTGCGTCCTTGCCCCGAGTGTGGCAAGAAGTACACGCGCAACTCACAGCTGAAGTCGCACATGTCATCGGTGCACAGATTGGGCGATTGCCTCAGCTACGATTGCACCGTGTGCCCAAAGAGATGTGCCTCGCTGCACGGCCTGCGCTATCATGTGAGATCGGCCCACTCCACGGAGCGACCCTTTGCCTGCGAAATCTGCGATCGTCGCTTTGTGCTGCGCACCCAGCTGATCTCGCACGCCCGCGTCCATACGGGCGAGACGAAGCCGCGGATCTTCAATTGTAATGTGTGCAAGAAGACGTGGCCAACGAAATCGGATTTGCGCACACACATGCGATCCCATGACCCGGACAAGTCCAAGCGGCCATTCAAATGTGATAAATGCGAGAAGGCCTTCTTTACGCGGGGCCATCTCAATTCGCACCATTTGGTGCACACCGGCGAGAAGCCCTACACCTGCACCTACTGCGACAAGTCGTATCAGAGTGTTGGCAATCTCAACAATCACATGGCGCGACAGCACACCAATCTGGGCAAGGATCACCAATCGAATCTAAACTACAACGGCTCCGTGGATATGGAAACGTGA
Protein Sequence: MFPLLLNRTVFVVCRCCLVEQPTLCHSIGDNQPLSIELLELVPNLEIKPSDVICQLCLHRLRDALEFRQRCQDSERILRARHEQALDDALECLEREVGCLEQAKSTSMSSLVDPVDFGTLDLSDTFESGYEPTNRTTSSVSWDSGILNTPIHLPASLEQLEQQQQQQQQQSNTIERPMDTKPKRKRSPRKAVAAVPRSRPHKSLRPCPECGKKYTRNSQLKSHMSSVHRLGDCLSYDCTVCPKRCASLHGLRYHVRSAHSTERPFACEICDRRFVLRTQLISHARVHTGETKPRIFNCNVCKKTWPTKSDLRTHMRSHDPDKSKRPFKCDKCEKAFFTRGHLNSHHLVHTGEKPYTCTYCDKSYQSVGNLNNHMARQHTNLGKDHQSNLNYNGSVDMET

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00567024;
90% Identity: iTF_00570579;
80% Identity: -