Basic Information

Gene Symbol
esg
Assembly
GCA_035043845.1
Location
JAWNMR010000491.1:23289816-23291459[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 7.1e-07 4.4e-05 23.6 2.0 1 23 376 398 376 398 0.98
2 5 3.6e-07 2.2e-05 24.5 0.5 1 23 411 433 411 433 0.98
3 5 1.6e-07 9.7e-06 25.6 1.0 2 23 438 459 437 459 0.97
4 5 4.9e-07 3e-05 24.1 4.0 1 23 465 487 465 487 0.98
5 5 8.2e-05 0.0051 17.1 0.6 1 19 493 511 493 513 0.97

Sequence Information

Coding Sequence
ATGCATACCGTGGAGCATATGCTAGTGGAAAAGAACTACAGCAAGTGTCCTTTAAAGAAGCGTCCCATCAACTATCAGTTCGAAGCGGAGCCCGAAGACTTGTGCCtcaaaaagaacaacagcagcaatgaggcgacaacaacaccaataaaaacagaactaacaacgacagcaacaacaagaattgaGGCAACAGTTGCTTCCAGCAACAGTTCTGAGGAGGAGCTGATCAATGTGAGCGATTGCTGCGAGGACGAGGGCGTCGATGTGGATCACACAGACGATGAGACGGAGCACATGGATGTCaacgaggatgaggatgatgtCGATTGTGTGAACATTGAGGCCGATCCCAAGCAGACGCAAGCCGCTgcattggctgctgctgccgctgtggcCGCAGCTGCCTCGGCTGCTGCAGTCGCCGCCTCGGTGGTGGTGCCGACACCCACCTATCCCAAATATGGTTTACAGACATGGAACTTTCACATGTCGCCGTACACCGCCGAATTCTATCGTACCATCAATCAGCCGCATCTGtcagcagccgctgcagccgcAACTGTGGCGCCACTGCCCGCCGAGCTACTCTCGCCGAGCTCGCCATCGGACTCCTTGGGCTCGTTGTCGCCGCCACCACATCATTATTTGCACGGACGTGCCAGTTCGGTGTCGCCACCCATGCGCTCCGAGATGATCCACCGACCACAGCTGGGCGTTCGTCAtcttcagcagcaacaactacaccaacagcagcagcagccgccgcagacATTCCTGCCCTATCCGACATACCCGGCTGCGTACTatgctcatcatcatcatcatcagccgCTGCATGCGCCGATTTCTCCGGCCTACTCGGAGAGCTCCTATTACTCGATGCGCAGTTTGACGCCCGAGTCCAGCTGCTGTTCCGTACCCGAGGATCTCTCCCTGAAGCACAAACAGGCAGTAGCAactctgcagcagcaacaacaccagcaacaacagcagcctgCCGCACAGGACACCAATGGTTCCGTTTCATCATCGGGTGGAGCAGCAATTTCCTcctccgccgccgcctcctcTATGTCCGTCACCTCATCTCCCAGCAAGAAGGACAAATCAGCACCGCCACGTTATCAGTGTCCCGACTGCCAGAAATCCTACTCCACGTTTTCGGGGCTCACCAAGCATCAACAGTTCCATTGTCCCGCTGCCGAAGGCAACCAGGTGAAGAAGTCGTTCAGCTGCAAAGATTGCGACAAGACCTATGTGTCGCTGGGTGCACTCAAGATGCACATACGCACCCACACACTGCCCTGCAAGTGCAACATGTGTGGCAAGGCGTTCTCCCGTCCCTGGTTGCTGCAGGGCCACATTCGAACCCACACCGGCGAGAAGCCCTTCAGTTGCCAGCATTGCCATCGCGCCTTTGCGGATCGCTCCAATCTCCGGGCGCATCTGCAGACCCACTCGGACATTAAGAAATATTCGTGTGGCAACTGCTCGAAGACATTCTCGCGCATGTCGCTTCTGACGAAGCACAACGAAGGCGGCTGTCCGGGAGGCAGTggctccagttccagctccagctcgaGCTCGAGCGCCGTTGGCTCCCACTCTGAGCTATCCTATGGAGGCTACGCCGAGCCCTAG
Protein Sequence
MHTVEHMLVEKNYSKCPLKKRPINYQFEAEPEDLCLKKNNSSNEATTTPIKTELTTTATTRIEATVASSNSSEEELINVSDCCEDEGVDVDHTDDETEHMDVNEDEDDVDCVNIEADPKQTQAAALAAAAAVAAAASAAAVAASVVVPTPTYPKYGLQTWNFHMSPYTAEFYRTINQPHLSAAAAAATVAPLPAELLSPSSPSDSLGSLSPPPHHYLHGRASSVSPPMRSEMIHRPQLGVRHLQQQQLHQQQQQPPQTFLPYPTYPAAYYAHHHHHQPLHAPISPAYSESSYYSMRSLTPESSCCSVPEDLSLKHKQAVATLQQQQHQQQQQPAAQDTNGSVSSSGGAAISSSAAASSMSVTSSPSKKDKSAPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLPCKCNMCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCGNCSKTFSRMSLLTKHNEGGCPGGSGSSSSSSSSSSAVGSHSELSYGGYAEP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00535510;
90% Identity
iTF_00513643;
80% Identity
-