Basic Information

Insect: Drosophila persimilis
Gene Symbol: zfh1
Assembly: GCA_003286085.2
Location: NW:1249291-1277225[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00079 0.044 13.9 1.2 2 23 75 97 74 97 0.95

2 9 0.018 0.99 9.7 0.1 1 23 298 320 298 320 0.96

3 9 0.00011 0.0061 16.6 1.7 2 23 335 356 334 356 0.97

4 9 5.3e-06 0.0003 20.7 6.3 1 23 365 387 365 387 0.99

5 9 0.00032 0.018 15.2 1.2 3 21 395 413 393 414 0.94

6 9 0.0089 0.5 10.6 1.8 2 21 661 680 660 681 0.92

7 9 1.4e-05 0.00079 19.4 0.5 1 23 1043 1065 1043 1065 0.94

8 9 5.3e-05 0.003 17.6 7.4 1 23 1071 1093 1071 1093 0.98

9 9 0.0026 0.15 12.3 4.3 1 21 1099 1119 1099 1120 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00079	0.044	13.9	1.2	2	23	75	97	74	97	0.95
2	9	0.018	0.99	9.7	0.1	1	23	298	320	298	320	0.96
3	9	0.00011	0.0061	16.6	1.7	2	23	335	356	334	356	0.97
4	9	5.3e-06	0.0003	20.7	6.3	1	23	365	387	365	387	0.99
5	9	0.00032	0.018	15.2	1.2	3	21	395	413	393	414	0.94
6	9	0.0089	0.5	10.6	1.8	2	21	661	680	660	681	0.92
7	9	1.4e-05	0.00079	19.4	0.5	1	23	1043	1065	1043	1065	0.94
8	9	5.3e-05	0.003	17.6	7.4	1	23	1071	1093	1071	1093	0.98
9	9	0.0026	0.15	12.3	4.3	1	21	1099	1119	1099	1120	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTTCACGTTTTGGCCAAGAGGATAACAGCATCATACAGCAGAGCATGCCATCGTCCACAGCCTTCACCATGCAGTTTCCCTCCCTGGCCTCCAGTCTGCACCACCACCAGGCACCGCACAGCAAGGCGAGCAACGGCTCCGGTGGCAGCCAGGAGCAGCACGCCCAGCCAGGTGTCTCCGTGGACGACTTCCTGGTCAAGTGCCCGCAGTGCCACAAGCGCTTCACAGAGTTTCAGTCCCTCAGCGAACACATCGCCAGCGAGCACCCGCACGATAAGCTGAACTTTGAGGCCAGTCGCGGCTCCAGCGGCGCCGTGCAGCCCGAGAGCGATGCCGAGGACGAGCAGAGCAATCTGAGTGGCAGCCGGTACGCCAAGTCGCCCGCCACCACCGCCGTCACCCACGCCAcgcccagcaacaacaacaacagtgaTCTGGCCAAgaaccacaacaacagcaacagcagtaagATCTCTCCCATGTGCTCTCCGGGATCGGGGGGTcccgccaccaccgccgcaGCAGATCTCTTCGCCCACCTCTCGCACGGAGCCCCGCCCCAGCTGCCCTCCCACCTGCACGCCCAGTTCATGGCCGCCGCCGCCCTGGCCATGCAGTCGGCCCGCTCCGTCAGCTCCTCCGCCAGTTCGCCCAacagccaccaccaccaccagcagcagcaccagcagcagtcGCACCACCAtctccaacagcagcagctccaccagcaggcgcagcagctgctgccgccCCAGCTGCcgggcagcaacagcagcgtgGGCAGCAATTCCGCCTACGATCTGGACCTGAGCGCCCCGCGGTCCACCTCCAGTCCGGGCTCCACCACGGGCGACCTGAGCGGCGCCTACCCCTGCATGCAATGCACCGCCGCCTTCGGCAGCCGCGAACAGCTGGAGCAGCACGAGCTCCTCCACTCGCCCACTGGGGGCCAGCCCACGGCACAGAATGTCTCTCAGACTTGCCGAATCTGCCACAAAGCCTTCGCGAATGTGTACCGCCTGCAGCGGCACATGATCAGCCACGACGAGTCGGCGCTGCTGCGCAAATTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGGTTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGGGCGCTGCTCAAGCGCCTGGAGAAGAGTCCTGGCGCCGGGCCCCGACGCTCGCCCACGAACCTGCAGGGCCCCAAGAACGGCGCCGGAAAGATGTCCGAGCAACAGTCCCTGCCTCCGCTGCCCAATCCCATGATCTACTTTGCCGGCGAGGCACAGGCGCAGGCCGCGGCACCGAATGGAGCTCCTCCGCCGTTCTATCCCAACTACATGAATGCGGCCCTGCTGGCATTCCCCAATCCCTTCATGGCAGCAGCCCTGGATCCCCGCGTCCACCCCTACAGCATACAGCGGCTCCTGGAGCTGACGGCCgccggacagcagcagcagcagcaacaacagcagcagcaacgcgaGGAGCGCgaagagcaggagcagcacgAAGAGCCTGAGACGCCGGAGGAGCCCAAGCTGGTGATGGACATCGACGAGGCTGAGGCCAAGGAGCGTATGGTGCCACAGGCCAGCCCCCAGACCATGCCAGAGGAGATCGAACCCGTCGTCGATATGGCCACTGCTCCCATCAAGCAGGAGCCCAGCCGCGAGCCCACCCCACTCCCGGAGAGTGCACCGCCCTCGCCCAAGTCCTTcaagcaggagcaggaggagcccCGTTCCGTGGAGGAGGATCAGGCCATGGCGTCGGCTCAGCCCGAAGCCTCTGTCTCCTCCCCCAGGGGGGACACACCCGCCGAGCTGCGGTGCAGCCGCTGCGACAAGCAGTTCAACCACCACACGGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATCaaggaggagctggagcagcactaccaccagcagcagcagcagcagcagcaccaccaacagctccagcagcagcagcaccaccagcaggcGTCCTTTGCCCTGCCCTCTGCCAGCGAGGAtgacgacgaggaggaggagcgcgAGAACGACAACGACACGGAGCCGCGTCCGGACAGCAACGAGCGCAAGGTGCGCGTGCGCACGGCCATCaacgaggagcagcagcagcagctgaagcaGCACTACGCCCTCAATGCGCGGCCAAGTCGCGACGAGTTCCGGATGATTGCGGCCCGCCTCCAGCTGGATCCGCGCGTGGTCCAGGTCTGGTTCCAGAACAATCGGTCCCGCGAGCGCAAGATGCAGAGCTATGCCAGTGTCCACTCGGCAGCTCCTGCCGCCAATGAAGTGCCCACCACTCCAGTGGCCAGCCGTCCCACAACCGAGGATCAGCCCCTGGATCTGTCCGTGAAGCGCGACTCCCTGACGCCCAAGAGCGACCACTCTGCCGCGTACGGCTTGCCCCAGCAGCAGGCTGCCGGACAGCCAGGCCCCGCCGACTTCCAGGAGGCCATCAACCTGAGCCGCAAGTTCTCCAGCTCGGCCTCCATGTCGCCAGCCTCGCTGTCGCCTTCGTCGGGCGCCTCTCTGCAGCAGTCCTCGGCAGCTGCGGCCGCCGCTGCGGCAGCCCTCTGGCCCTTTGGTGGTCCGCCTCCATCGCCGCCCAGCCAGCTCGAGGTCACGCCCGCGCAGCACTGCTCGACGCCGCGAGGCGGCCAGGCCTTCCCCGGACTCCAGTACATGCTCCCCATGCAGCGGCTCCCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATGAACAGTATTAAGATGCCCGACTTCCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAAAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGACTTCGGCAACGGCCTGATGCCCCCCAAGCCCCGTCGCGGCAAGGCCGAGACCCACGGGCATGCCGGCGATCCGGATCTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCCTGGCGAGGCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCACAAGCGGCTGCACAGCGGGGAGAAGCCCTTCCAGTGCTCCAAGTGCCTGAAGCGCTTCTCGCATTCGGGGAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKASNGSGGSQEQHAQPGVSVDDFLVKCPQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPATTAVTHATPSNNNNSDLAKNHNNSNSSKISPMCSPGSGGPATTAAADLFAHLSHGAPPQLPSHLHAQFMAAAALAMQSARSVSSSASSPNSHHHHQQQHQQQSHHHLQQQQLHQQAQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFGSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGAGPRRSPTNLQGPKNGAGKMSEQQSLPPLPNPMIYFAGEAQAQAAAPNGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQQQQQQQQREEREEQEQHEEPETPEEPKLVMDIDEAEAKERMVPQASPQTMPEEIEPVVDMATAPIKQEPSREPTPLPESAPPSPKSFKQEQEEPRSVEEDQAMASAQPEASVSSPRGDTPAELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQQQQQQHHQQLQQQQHHQQASFALPSASEDDDEEEERENDNDTEPRPDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYASVHSAAPAANEVPTTPVASRPTTEDQPLDLSVKRDSLTPKSDHSAAYGLPQQQAAGQPGPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGPPPSPPSQLEVTPAQHCSTPRGGQAFPGLQYMLPMQRLPMEALFQMRPGGEYAPNPLMNSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKPRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00574713;