Basic Information

Insect: Drosophila persimilis
Gene Symbol: ZEB2
Assembly: GCA_003286085.2
Location: NW:28313058-28315700[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.16 8.9 6.7 0.7 1 23 46 68 46 68 0.88

2 13 0.047 2.6 8.3 2.8 2 21 121 140 120 144 0.86

3 13 0.0013 0.075 13.2 1.1 1 21 144 164 144 165 0.95

4 13 0.0061 0.34 11.1 0.2 1 23 197 219 197 219 0.96

5 13 0.0023 0.13 12.5 0.4 2 23 242 263 241 263 0.96

6 13 0.018 0.99 9.7 0.2 1 23 269 291 269 291 0.96

7 13 1.5 86 3.6 0.2 3 20 315 332 313 334 0.91

8 13 0.032 1.8 8.8 0.3 1 23 341 363 341 363 0.96

9 13 5.8e-07 3.3e-05 23.8 4.9 2 23 501 522 501 522 0.98

10 13 5.5e-05 0.0031 17.6 1.2 1 23 528 550 528 550 0.97

11 13 2.9e-05 0.0016 18.4 1.1 1 23 556 578 556 578 0.98

12 13 2.1e-05 0.0012 18.8 0.9 1 23 584 606 584 606 0.97

13 13 6.4e-06 0.00036 20.5 0.7 3 23 614 635 613 635 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.16	8.9	6.7	0.7	1	23	46	68	46	68	0.88
2	13	0.047	2.6	8.3	2.8	2	21	121	140	120	144	0.86
3	13	0.0013	0.075	13.2	1.1	1	21	144	164	144	165	0.95
4	13	0.0061	0.34	11.1	0.2	1	23	197	219	197	219	0.96
5	13	0.0023	0.13	12.5	0.4	2	23	242	263	241	263	0.96
6	13	0.018	0.99	9.7	0.2	1	23	269	291	269	291	0.96
7	13	1.5	86	3.6	0.2	3	20	315	332	313	334	0.91
8	13	0.032	1.8	8.8	0.3	1	23	341	363	341	363	0.96
9	13	5.8e-07	3.3e-05	23.8	4.9	2	23	501	522	501	522	0.98
10	13	5.5e-05	0.0031	17.6	1.2	1	23	528	550	528	550	0.97
11	13	2.9e-05	0.0016	18.4	1.1	1	23	556	578	556	578	0.98
12	13	2.1e-05	0.0012	18.8	0.9	1	23	584	606	584	606	0.97
13	13	6.4e-06	0.00036	20.5	0.7	3	23	614	635	613	635	0.96

Sequence Information

Coding Sequence: ATGGTGTATCATCGATGTTTTTCCACCTCTACCGAGAACCAAGAAAGCGATGACAGGGAAAAGTTGGTCACACCGTATGAGTTCAAGTGGAGCGGCAAGATATTATCCCCCAGGCGTCGCTGTGGCACGATGCGTTTTCTTTGTGATGTTTGTGGCAAAGGATTTATAGCTGAGAACCACCCGAAAAGACATACCACCAGTCACAATAACAATCAGATGGCGGAAATCAGCAAAAGGAAGCCTCTTAGAAGTAAGAACACGTATCAAAGTCCGTCGCAGAAAAATAGGACCCTAGTAGACCTCAACAATGATCGTCTGGAAAGCATTTCTCCCAGAAAAATTCGTAGTACCGCAGAACTTCCATGTCCGCAATGCTATAAATGTTTTGACTCACAGGACAAGCTCGAATTTCACATTGATAAGATGTGCCATAAGTGTCCCCACTGCTCACGCTTTTATGCAAATGAACGTAGTCTAGGGAGACATCAACAAGAGAACATTCCACTGGCAGCCTTTGAGGGCCCGCGATCATTATCGAACATGAATGAGCTGAGGGAGCCGCGTGTCAAGCACAGCGACAATGGCCTGTTTAAGTGCCAAGAATGCAATGCAGTATTCATCGACATCCTTTATCTGCAGATCCACAGTAAAGAGCACACTAATGAGCATAGGCATCGTAGTCTGTTCAGACATACCAAGAACGACATTACAATGACAGCCTTACAGTGCACGCGTTGCCCGCGTTCATTCCCTAACATCCGTGAGGTGATGAAGCACCGTGTCACGCACAGCGGCGTTGGCCTGTTTAAATGCCAAGAATGCAATGCGGAATTCATCGACATCCTTTATCTGCAGATCCACAGTAAAGAGCACACTAATGAGCATAGGCATCGTAGTCTGTTGAGACATACCAAGAACTACATTCCAATGACAGCCTTAGATTGCACGCGTTGCCCGCGCTCATTGCCGAACATCCATGAGGTGATGAAGCACCGTGTCAAGCAAAGTGACAATGGCCTGTTTAAATGCCAACAATGCAATGCGGAATTCATCGACATCCTTTATCTGCAGATCCACAGTAAAGAGCACACTGGTGAGCAAGGGCAACTAGAGCGTAGCCGAGGAGTCACACTCCCTAGGGTTAAGAAACAGGTCGACTCCGACTCGAAGAAGAGTGTTTTAGAAATGTTTTCCTGCCATGACGCTAATAGTCGCTCAAAGAGTCCAACAATGATAAAGAAGATGAAGCTCACCGACCCCGACCTTGCTATATCAAGCGCCACAAAGAAGAGCTGCATGACCCAATCCTTGCCAATAAAACAGGTCGACTCCGACTCGAAGAAGAGTGTTTTAGAAATGTTTTCCTGCCATGACGCTAATAGTCGCTCAAAGAGTCCAACAATGAAAAAGAAGATGAAGCTCACCGACCCCGACCCTGCTATATCAAGCCCCACAAAGAAGAGCTGCATGACCCAATCCTTGCCAATAAAACTGGAAAATACATGCCAGCAGTGCGGTAAGAAATTTACCTATAAACATTCCCTGACTAGGCACATGCGTGTTCACACTGGAGAGCGTCCTTTTGAATGCACGTATTGCGAGAAGAAATATTCGCGCAAGGCTCAGCTAGATGAGCACACTACTATCCACACTGGCGACCGTCCTTTCGAGTGCTTGGTTTGCGAGAAGAAATTTATTCGCAAGATACACCTAGCTGAGCACACTCGTATTCACACTGGCGACCGTCCTTACGAGTGCTTGGCTTGCGACAAGACTTTTCCGCGCAAGTATACCCTGCTTAAGCACAATCGTATCCACACTGGTGATCACCATTCCGATTGCCCGCAATGCGACAAAAAATTTAGAGATAACTACGCACTACAACAACACTTTCGTAATATTCACAATTGCGAACGTCGTAACGAGAAAAATAATCAAGGGTTCCTCAAGAAGAAGGAAAAAAGCTTTGACGAAAGTTATAAACTGGAGATACACGAAAGAAAGGCGTCGAATAACAACAATATGCCTGGACAGCATTTGGACATTAAGGATGAAATCGCTTGA
Protein Sequence: MVYHRCFSTSTENQESDDREKLVTPYEFKWSGKILSPRRRCGTMRFLCDVCGKGFIAENHPKRHTTSHNNNQMAEISKRKPLRSKNTYQSPSQKNRTLVDLNNDRLESISPRKIRSTAELPCPQCYKCFDSQDKLEFHIDKMCHKCPHCSRFYANERSLGRHQQENIPLAAFEGPRSLSNMNELREPRVKHSDNGLFKCQECNAVFIDILYLQIHSKEHTNEHRHRSLFRHTKNDITMTALQCTRCPRSFPNIREVMKHRVTHSGVGLFKCQECNAEFIDILYLQIHSKEHTNEHRHRSLLRHTKNYIPMTALDCTRCPRSLPNIHEVMKHRVKQSDNGLFKCQQCNAEFIDILYLQIHSKEHTGEQGQLERSRGVTLPRVKKQVDSDSKKSVLEMFSCHDANSRSKSPTMIKKMKLTDPDLAISSATKKSCMTQSLPIKQVDSDSKKSVLEMFSCHDANSRSKSPTMKKKMKLTDPDPAISSPTKKSCMTQSLPIKLENTCQQCGKKFTYKHSLTRHMRVHTGERPFECTYCEKKYSRKAQLDEHTTIHTGDRPFECLVCEKKFIRKIHLAEHTRIHTGDRPYECLACDKTFPRKYTLLKHNRIHTGDHHSDCPQCDKKFRDNYALQQHFRNIHNCERRNEKNNQGFLKKKEKSFDESYKLEIHERKASNNNNMPGQHLDIKDEIA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00580945;
90% Identity: iTF_00580945;
80% Identity: -