Dpeg003554.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila pegasa
Gene Symbol
Sp4
Assembly
GCA_035046225.1
Location
JAWNOD010000076.1:15716782-15717963[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 0.00028 0.017 15.4 1.7 1 23 118 142 118 142 0.96
2 5 2.8e-08 1.7e-06 28.0 0.5 1 23 148 172 148 172 0.98
3 5 4.7e-05 0.0029 17.8 6.5 1 23 178 200 178 200 0.97
4 5 1.1e-06 6.5e-05 23.0 4.0 1 23 339 361 339 361 0.99
5 5 0.00045 0.028 14.8 7.0 1 23 367 389 367 389 0.98

Sequence Information

Coding Sequence
ATGTCACAAATAATTCCAAACACACCCACGCCTCAAATGCTGACGACATCAACAATAACACCCGTCGACGCAGCAGCAAAGCCGCAACTCTCTTTTCCATCTCTAGCTGATGGGGCGCACGCAAACAATCTGCTGGCCCCGACCCCAGATGTAATACTTAGAGCCTCAACAATATTTGGCGAGTTCAAGCACGGCTCCCCAATGGATCTCGATAATAATGTACATAAAACGGTGGAGACTGAGCACAACATGCTGTCGGACGGCCTGGAATTTGGTAGCGACTCTAAGATTCGAATAATGCCAACAGTGAAGCTGCTTGCGGCCCCCCATGCAGCGGATCCCAAACGAAAATTCGTCTGTCCCTATGATAATTGCACGAAAAGTTATGGAAAGAGTTCCCACCTTCGGTCCCATCTGACATGGCACACGGGCATCAAGCCGTTCGTCTGCACCGAGGTCAAGTGCGGGAAGGGCTTCACGCGCTCCGACGAGCTGAACCGCCACTTGCGCACCCATACGGGCGAAAAGCCCTTCAAATGCATACACTGCAGTAAAAAGTTCTCGCGCAGCGATCATCTGACCAAGCACTTGGCCACGCACGACCGACAGCTGAAGAGCAACAATCCGAAGCGTGCGTCGCTGTCCAACTCGACCCGGGTgaagggagagaaaaagaatgCCTCGGACGCCGACTCGGGCTATCACTTTATGGCCGTCATCAATGGCGGCGAATCGAACcccaatcaaaatcaaaatcaaaatcatcaAGCGCAGCCAGCACCCGTGGCCGCCTATGACCACACGCCATTCAGAATTAAACTGGAGCGACCGGAGCACAGTGacaaatatcaaatcataGCCCCGCTACCTGATAACCAGTTGACGGCGGGCCTCAGCGATAAGCCGGACGTGAAGTACGAGCCCGCCGAGGACATCTCACGCACACTCTCGCAATTGCCGCCCCAGGACGGCTCCAGTACCTATGGGATGCCTCACTTTGTGCAAGACCGGCCCTTTCGCTGTCGGCAGTGTGAGAAGCGCTTCAAGCGCCAGGACGATCTGAATCGGCACAATCGCACGCACACGGGCGAGAAGCCCTATGCGTGCACCCAATGCTGCCGACGCTTCGTGCGCAGCGATCACCTGAAAAAACATCAACAGACCCATTTGAAATCGCGATAG
Protein Sequence
MSQIIPNTPTPQMLTTSTITPVDAAAKPQLSFPSLADGAHANNLLAPTPDVILRASTIFGEFKHGSPMDLDNNVHKTVETEHNMLSDGLEFGSDSKIRIMPTVKLLAAPHAADPKRKFVCPYDNCTKSYGKSSHLRSHLTWHTGIKPFVCTEVKCGKGFTRSDELNRHLRTHTGEKPFKCIHCSKKFSRSDHLTKHLATHDRQLKSNNPKRASLSNSTRVKGEKKNASDADSGYHFMAVINGGESNPNQNQNQNHQAQPAPVAAYDHTPFRIKLERPEHSDKYQIIAPLPDNQLTAGLSDKPDVKYEPAEDISRTLSQLPPQDGSSTYGMPHFVQDRPFRCRQCEKRFKRQDDLNRHNRTHTGEKPYACTQCCRRFVRSDHLKKHQQTHLKSR