Dpeg006399.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila pegasa
Gene Symbol
ESRRB
Assembly
GCA_035046225.1
Location
JAWNOD010000286.1:1236644-1238156[-]

Transcription Factor Domain

TF Family
THR-like
Domain
zf-C4|THR-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. TR interacts with the thyroid response element, which is a DNA site with direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs, upstream of target genes and modulates the rate of transcriptional initiation. Thyroid hormone receptor (TR) mediates the actions of thyroid hormones, which play critical roles in growth, development, and homeostasis in mammals. They regulate overall metabolic rate, cholesterol and triglyceride levels, and heart rate, and affect mood. TRs are expressed from two separate genes (alpha and beta) in human and each gene generates two isoforms of the receptor through differential promoter usage or splicing. TRalpha functions in the heart to regulate heart rate and rhythm and TRbeta is active in the liver and other tissues. The unliganded TRs function as transcription repressors, by binding to thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and being associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator to activate transcription. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [4, 3, 5, 2, 7, 1, 6]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.8e-09 2.8e-06 26.9 0.0 20 175 301 449 287 479 0.74

Sequence Information

Coding Sequence
ATGTCCGACGGGGTCAGCGTGCTGCACATTAAACAGGAGGTGGACACATCATCGGCTGGCGGCGCCAGCAATTCGTGCTGCAGTCCCAGCTCCAAGGCAACCGCCGGCCACAACAattccagcaacagcaacagcggcatgAAGTCCTCGCCGTCCGTGTCGCCGGAGCGCCAGCTGTGCAGCTCGACCACGTCCCTCTCCTGCGACCTGCACAACGTCTCGCTGAGcaacgacggcgacagcaacaaggGCAGCGGcgccaacagcggcagcagcggcgcccaGAACTCGAGCGCGAACGCGGGCAGCTCGGGCTCGGTGCGCGACGAGATGCGGCGCCTGTGCCTGGTGTGCGGCGACGTGGCGTCCGGCTACCACTACGGCGTGGCCAGCTGCGAGGCCTGCAAGGCCTTCTTCAAGCGCACCATCCAGGGCAACATCGAGTACACCTGCCCGGCGAACAACGAGTGCGAGATCAACAAGCGGCGGCGCAAGGCCTGCCAGGCGTGTCGCTTCCAGAAGTGCCTGCTCATGGGCATGCTGAAGGAGGGCGTTCGCTTGGATCGAGTGCGCGGCGGTCGGCAGAAATATAGACGCAATCCGGTGTCCAACTCGTACCAGACCATGCAGCTGCTTTACCAGTCCAGCACCACGGCGCTGTGCGACGTCAAGATCCTGGACGTGCTCAACAGCTACGAGCCGGATGCGCTCAGCGTgcaggcacagcagcagcagcagccgcacacGACCAGCTTGAACGATGAGGCGTCCTCCTCGTCCGGCAGCGTCAAGCTGGAGGGCAGCAACGGCACGTCGAACGGCACTTGCATTTtccagaacaacaacaatgacccGAACGAGATACTCGGCGTACTCAGCGATCTCTACGACAAGGAGCTGGTCAGCGTGATTGGGTGGGCCAAGCAGATACCGGGCTTCATCGAGCTGCCGCTGAACGACCAGATGAAGCTGCTGCAGGTCTCCTGGGCGGAGATCCTGACGCTGCAGACCACCTTCCGCTCGCTGCCGTTCAACGGCAAGCTCTGCTTCGCCACCGACGTGTGGATGgacgagctgctggccaaggagTGCGGCTACACGGAGTTCTACTACCACTGCGTGCAGATCGCGCAGCGCATGGAGCGCATCTCGCCGCGCCGCGAGGAATACTATCTGCTgaaggcgctgctgctgtccaacTGTGATATACTGCTGGACGACCAGAGCTCGTTGCGCGCCTTCCGCGACACCATACTCAACTCGCTCAACGACGTGGTCTACCTGCTGCGCCACTCCTCGGCCGTctcgcaccagcagcagctgctgctgctgctgccgtcgctgcggCAGGCGGACGACATCCTGCGCCGCTTCTggcggggcgtggcgcgcGACGAGCACATCAACATGAAGAAGCTGTTCCTCGAGATGCTCGAGCCGCTGGCCAGGTGA
Protein Sequence
MSDGVSVLHIKQEVDTSSAGGASNSCCSPSSKATAGHNNSSNSNSGMKSSPSVSPERQLCSSTTSLSCDLHNVSLSNDGDSNKGSGANSGSSGAQNSSANAGSSGSVRDEMRRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSSTTALCDVKILDVLNSYEPDALSVQAQQQQQPHTTSLNDEASSSSGSVKLEGSNGTSNGTCIFQNNNNDPNEILGVLSDLYDKELVSVIGWAKQIPGFIELPLNDQMKLLQVSWAEILTLQTTFRSLPFNGKLCFATDVWMDELLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLKALLLSNCDILLDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQQLLLLLPSLRQADDILRRFWRGVARDEHINMKKLFLEMLEPLAR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00583737;
90% Identity
iTF_00546711;
80% Identity
iTF_00572618;