Basic Information

Insect: Drosophila pectinifera
Gene Symbol: NFYC
Assembly: GCA_008042775.1
Location: VNKC01004727.1:3942-6223[+]

Transcription Factor Domain

TF Family: NF-YC
Domain: NF-YC domain
PFAM: AnimalTFDB
TF Group: Other Alpha-Helix Group
Description: Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [1]. CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' [2], seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 1 1.6e+04 -5.4 7.4 144 180 42 79 27 140 0.59

2 4 5.3e-51 8.3e-47 159.7 0.2 18 127 153 262 136 270 0.95

3 4 1 1.6e+04 -16.6 29.1 135 212 332 407 327 410 0.60

4 4 1 1.6e+04 -12.7 59.5 139 243 382 504 368 510 0.69

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	1	1.6e+04	-5.4	7.4	144	180	42	79	27	140	0.59
2	4	5.3e-51	8.3e-47	159.7	0.2	18	127	153	262	136	270	0.95
3	4	1	1.6e+04	-16.6	29.1	135	212	332	407	327	410	0.60
4	4	1	1.6e+04	-12.7	59.5	139	243	382	504	368	510	0.69

Sequence Information

Coding Sequence: ATGTACGCCACGAACAATGGCGGGACGAACAAGGCGTCAAACAGCAGTGGCACCTCCATGTTCGACAACACCATCACCGTAACCCCAATCAAGGTGGAACTGAGCTCGGCCGTCGCCCAGGCGTACGCCGCCGGCAAGAGCCAAGCTCCAACGGCGGCGACGGTGCAGCGAAGGACGCCCAACGCGGTGGTggtgaccaccaccaccagcaataaccaacaccagcagcagcagacgctgCAGCTGGCGGGAGGCGGAGGCTCCACCGCCACGCTCACGCTACCCATGCAGGCGACACTGGTGTCCTCCAATAATGCCTCCTGCACCATCGTCAATCCTGGTGGCATGAGTGTGACGACGGTGAATGCCAACAGCGCCGCCAGCACAACGGGGAGCACGCCGAAGGAGAAGACGACGAAGGCGAGCAGGGCGCAGGTGGCGCGAAAACCGCCGCCGACTATCGacaatttctggccaaacaTTGTCAGCGAGGTGCATGGGATTGGGCAGGTGGACGCGAAGCATCAggtgctgccgctggcgcGCATCAAGAAGATCATGAAGCTGGACGAGAACGCCAAGATGATTGCCGGCGAGGCGCCACTGCTGTTTGCCAAGGCCTGCGAGTACTTCATCCAGGAGCTGACGATGCACGCCTGGGTGCACACGGAGGAGAGTCGACGACGGACGCTCCAACGCTCGGACATAGCCCAGGCGATTGCCAACTACGATCAGTTCGATTTCCTCATCGACATTGTGCCGCGCGAGGAAATCAagccatcgtcgtcgtcgtcatcgtcgtcggcgCAGAAGCAGGGCAAGgatggcagcggcggcatgACGGGGTCCGTCTCTGGAACGTCGTCCGCCTCTACAGCTGGCAGCGCTTCGGCCACGGGCAACTTTGTCGCCGGTGGTTCCACCGTACCTGCGGCCGCCGTCGGTGGCCTCAAGCTGGATGGCGTCGCTGGCACGAGTGCGGGCGAGGTGCTCAGCTTCACTCCCGTCAATCCGGACATCTTCTCCGctcaactgcagcagcagcagcacgccgcccagcagcaacaggcgcaccagcagcaccatcatcatcaggcACATCCCCAGCAGGTGCAGATAATACAGCAGGCCGGCCATCCTGGaggccagcagctccagtACTTCATAGCGCTGCCCGGTCAGCAAGCGGCGCAGCTGGtccagcaggtgcagcagcaacagcagccgcagcccgCTCAGAATCATCTCGCGAATAGTCTGGGACTCAACATTGTCACCGCCCAGCAACCCACACAGCAGTTGATCCTCACCGCCGGTCCCAATGGCCAGCTAACAGCCACGCCCGCGCCACAAACGacggcccagcagcagcagacggcCCTGCTCCAGAAtctcgcccagcagcagcaggcgcaacagcagcagcagcaacaacaacagcagcagcagatccagCTAATCCAGCAGGTAGTGACGCCCACGGGCGAGGTGACCAATGTGCCGTACCATGTCCGGGGACCGTGGAGGTTATCGGTAAAACCCCCAGCCAAGACCTGGACAACGGTAGCAATCATATCGAAGCATCGGGAGGCACTGGAATCGCGCGGGAACTGA
Protein Sequence: MYATNNGGTNKASNSSGTSMFDNTITVTPIKVELSSAVAQAYAAGKSQAPTAATVQRRTPNAVVVTTTTSNNQHQQQQTLQLAGGGGSTATLTLPMQATLVSSNNASCTIVNPGGMSVTTVNANSAASTTGSTPKEKTTKASRAQVARKPPPTIDNFWPNIVSEVHGIGQVDAKHQVLPLARIKKIMKLDENAKMIAGEAPLLFAKACEYFIQELTMHAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSSSSSSSSAQKQGKDGSGGMTGSVSGTSSASTAGSASATGNFVAGGSTVPAAAVGGLKLDGVAGTSAGEVLSFTPVNPDIFSAQLQQQQHAAQQQQAHQQHHHHQAHPQQVQIIQQAGHPGGQQLQYFIALPGQQAAQLVQQVQQQQQPQPAQNHLANSLGLNIVTAQQPTQQLILTAGPNGQLTATPAPQTTAQQQQTALLQNLAQQQQAQQQQQQQQQQQQIQLIQQVVTPTGEVTNVPYHVRGPWRLSVKPPAKTWTTVAIISKHREALESRGN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00531638;
90% Identity: iTF_00531638;
80% Identity: -