Basic Information

Insect: Drosophila paulistorum
Gene Symbol: topi
Assembly: GCA_018152135.1
Location: JAECXG010000690.1:8412525-8416233[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 2.2e-05 0.0017 18.8 0.9 1 23 257 279 257 279 0.98

2 10 0.26 20 6.0 0.3 2 23 306 327 305 327 0.94

3 10 0.13 9.8 6.9 0.1 2 23 387 408 386 408 0.96

4 10 2.9 2.3e+02 2.7 0.1 1 20 414 433 414 435 0.79

5 10 0.037 2.9 8.6 0.1 1 20 455 474 455 475 0.95

6 10 4.9e-07 3.8e-05 24.0 1.9 1 23 537 559 537 559 0.95

7 10 0.0005 0.038 14.5 1.1 1 23 565 590 565 590 0.96

8 10 0.42 33 5.3 1.7 1 23 596 618 596 618 0.88

9 10 3.7e-08 2.9e-06 27.5 0.4 1 23 624 646 624 646 0.99

10 10 0.0017 0.13 12.9 2.0 1 23 652 675 652 675 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	2.2e-05	0.0017	18.8	0.9	1	23	257	279	257	279	0.98
2	10	0.26	20	6.0	0.3	2	23	306	327	305	327	0.94
3	10	0.13	9.8	6.9	0.1	2	23	387	408	386	408	0.96
4	10	2.9	2.3e+02	2.7	0.1	1	20	414	433	414	435	0.79
5	10	0.037	2.9	8.6	0.1	1	20	455	474	455	475	0.95
6	10	4.9e-07	3.8e-05	24.0	1.9	1	23	537	559	537	559	0.95
7	10	0.0005	0.038	14.5	1.1	1	23	565	590	565	590	0.96
8	10	0.42	33	5.3	1.7	1	23	596	618	596	618	0.88
9	10	3.7e-08	2.9e-06	27.5	0.4	1	23	624	646	624	646	0.99
10	10	0.0017	0.13	12.9	2.0	1	23	652	675	652	675	0.96

Sequence Information

Coding Sequence: ATGAGTGACTTAGATTTGTGGAACTTGCAAACGGAAAATGCTTCCGGAGAATATACTGTGGCTGAAATCGAGGTGGTAGATGGAGAGGGTTTCATGGCTGATGGACTGCAGCTGGGTGCCACTGTACTGGCCTCGAATGAGGGTGATGGGACTGTGGAACAAGTTTTTGCCACCGAGGAATTATCCAAGATTTTTGCGACAACGCCAAAGGCCAATGTTGAAATACCCACAGAGGTGGTCGTGCAGCGTACTCTAGCGGATCCGGCTCTGAAGCAGATTTTACAGGAGGCTGATGGTACAGCTGGATTTGATCCAGAGGCTGAACAGTTGAAAATTCGAGATTTTCTAGCTGGTGTCAACAAGGGCAAGATGACCATGGAGGAGAGCGTTTTTCATGCACCTCGTGCCGGAACTTTATCGAGTGCAACATCAAATCGCACTATCAAATGCAGCAAATGCAATTTGGTTTGCGATGTGCATTCCATCAGTAAGCATACAAGTGAATGCGAAGCTGATGGCAACANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGACAAAGTCACCGTCAAAGTGGAGCCGCCGGAATTGGAAGCCGAACCGCCTATATCGTCCAGCGAACGCGTCTTACAGGAGAACCAGATACGATTGCGTCGCTATATGAAGGATGAACTGAAGTGCGATCTGACTACTGGAGCGATGAACTCCCGTGTCAAAAAGGCATCAAAAGGACCCTATGAGTGCGCCATGTGCGAGCGTAAGTTTGTCCATGAGTCTGGCCTGTTACGTCATATGGAGAAGCATTTCCTCGATCAGATTCCGACTCATAGCGTTCAGCCAAATGTGATAGCACCACCACCTCGAGGATTGCATGTGGTTCTTAAGTGCAATGCCTGTGGACGTATCTTTTTCAATGTGAAATTTGCCAAAGATCATTTATTGATTCATTTTCCACCGCCGCCGCAGTTTAGCAAACCCAAAGCCGCACTTAAGGATAGCTTTGACATAGATCAGTTCCTGTTGGAAGGGGATCAACTGCTCGCCACCTTGTCCAAAGACGTTTGTAGCGTTAGGTCGCCTTTAGAACTCGAAATGTTGGAGACTATAATGTTGCACAGCGTTCTGCAGTGCGAGTTCTGTGAATTTCTATTTGCGGACATCTCTGAACTGCTCATCCATTCGGCCACCCATTATGCTGAGAGACGGTTTGAGTGCACGGTATGCGACTTGACCATGAATACGGCCAAGGAGGCAAGTGTACACTTTCAGACCGACTGCGTTTTTATGCGTGAAGGACTTAAACTGCTAAATGTCACATTGAAACGTTATTTCGTGTGCAATGTATGTGAGCTTAAGTACCCTAATACAGAACTACTGCAGGAGCATCGAAGCTGCTCCTTACATTACTTTCCTCGCCTTAGTGAGCATAGCCAACGTCTGCTTTTGCCATGCGAATTTTGTGAGGTTAATTTTGAATTCGCCCATGAGATATTTCCCCACATTGAGGAGAAACATTTGAACAAGAAGAAAAGAGAAAAGGAGGCCCGTAACACTGGACCCGGCCGGGTACGTCAGTATTTGTGTGATATTTGCGGCAAATCATACACCCAGTCTAGTCATCTCTGGCAGCACTTGCGCTTCCATCAGGGCGTGAAGCCCTTTGTTTGTCAGGAGGAGAACTGCGGCAGGAAATTTACTATTCGTCCGGATCTTAATGATCACATTCGCAAGTGCCACACTGGAGAGCGGCCTTATCATTGTTTGGTATGTGGCAAGCGTTTCCTAACGGGATCCGTGTTCTATCAGCATCGTCTGATCCATCGTGGGGAGAGGCGCTATGAGTGCGATGAGTGCGGCAAGCGATTCTATCGTGCGGATGCCTTGAAAAACCATCAACGTATTCATACGGGTGAGAAACCATATAGTTGTCTATTCTGCACCAAGACCTTCCGACAGCGAGGCGATCGCGATAAACATATCCGTGCACGTCACTCTCATTTGGATGCCAATGCGCGACTCATGATGCAAATGCAGAAATTTCAACTGGAGGCCAAGGCCAAAAAAACTGTAAATAATAAGACCAATGAACCTGTGCCAATTGAGGACAACGGTATTCTTGATATTCCTGATATTCCTGCAATGCCAGAGCATCAGGATGAGGCCACTTCTGGGCATGACAATGGAGACCATGTTGAGACCTTAAATGAAGAGATCTTCTCCGATTTGATAGCTGGTAACGAAGTCGTCGTGGCTGAAGATGTGTTTCAGGAGCCGATACAGGACGATATAAACAATATCAATAATGACGACATTATCATGAGCATATTCGATCCTATCCCAGAACCAAGTCAATCCACGATTTTGGAAAACATTCCTTTGCTGCAGAATCACGACAATGCCAAAGTGGTGGTAGTCAAAAATAATCCCTTACAGCCGATGTTTTCGGATGCTTATATGTGA
Protein Sequence: MSDLDLWNLQTENASGEYTVAEIEVVDGEGFMADGLQLGATVLASNEGDGTVEQVFATEELSKIFATTPKANVEIPTEVVVQRTLADPALKQILQEADGTAGFDPEAEQLKIRDFLAGVNKGKMTMEESVFHAPRAGTLSSATSNRTIKCSKCNLVCDVHSISKHTSECEADGNXXXXXXXXXXXXXXXXXXXXXXDKVTVKVEPPELEAEPPISSSERVLQENQIRLRRYMKDELKCDLTTGAMNSRVKKASKGPYECAMCERKFVHESGLLRHMEKHFLDQIPTHSVQPNVIAPPPRGLHVVLKCNACGRIFFNVKFAKDHLLIHFPPPPQFSKPKAALKDSFDIDQFLLEGDQLLATLSKDVCSVRSPLELEMLETIMLHSVLQCEFCEFLFADISELLIHSATHYAERRFECTVCDLTMNTAKEASVHFQTDCVFMREGLKLLNVTLKRYFVCNVCELKYPNTELLQEHRSCSLHYFPRLSEHSQRLLLPCEFCEVNFEFAHEIFPHIEEKHLNKKKREKEARNTGPGRVRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANARLMMQMQKFQLEAKAKKTVNNKTNEPVPIEDNGILDIPDIPAMPEHQDEATSGHDNGDHVETLNEEIFSDLIAGNEVVVAEDVFQEPIQDDINNINNDDIIMSIFDPIPEPSQSTILENIPLLQNHDNAKVVVVKNNPLQPMFSDAYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00618653;
90% Identity: -
80% Identity: -