Basic Information

Insect: Drosophila paulistorum
Gene Symbol: lin-28
Assembly: GCA_018152135.1
Location: JAECXG010000606.1:15030765-15049521[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 3e-05 0.0023 18.3 2.5 1 23 786 808 786 808 0.99

2 10 9.1e-06 0.0007 20.0 5.1 1 23 814 836 814 836 0.98

3 10 1.9e-06 0.00015 22.1 4.3 1 23 842 864 842 864 0.98

4 10 0.00063 0.049 14.2 2.4 1 23 870 892 870 892 0.97

5 10 0.00011 0.0083 16.6 0.1 1 22 898 919 898 919 0.96

6 10 4.9e-05 0.0038 17.7 2.7 1 23 986 1008 986 1008 0.99

7 10 1.7e-06 0.00013 22.3 3.0 1 23 1014 1036 1014 1036 0.98

8 10 4.3e-06 0.00033 21.0 2.1 1 21 1042 1062 1042 1063 0.96

9 10 0.00063 0.049 14.2 2.4 1 23 1070 1092 1070 1092 0.97

10 10 0.015 1.2 9.8 0.0 5 22 1101 1118 1100 1118 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	3e-05	0.0023	18.3	2.5	1	23	786	808	786	808	0.99
2	10	9.1e-06	0.0007	20.0	5.1	1	23	814	836	814	836	0.98
3	10	1.9e-06	0.00015	22.1	4.3	1	23	842	864	842	864	0.98
4	10	0.00063	0.049	14.2	2.4	1	23	870	892	870	892	0.97
5	10	0.00011	0.0083	16.6	0.1	1	22	898	919	898	919	0.96
6	10	4.9e-05	0.0038	17.7	2.7	1	23	986	1008	986	1008	0.99
7	10	1.7e-06	0.00013	22.3	3.0	1	23	1014	1036	1014	1036	0.98
8	10	4.3e-06	0.00033	21.0	2.1	1	21	1042	1062	1042	1063	0.96
9	10	0.00063	0.049	14.2	2.4	1	23	1070	1092	1070	1092	0.97
10	10	0.015	1.2	9.8	0.0	5	22	1101	1118	1100	1118	0.93

Sequence Information

Coding Sequence: ATGCGTGAGGAGGATTTCGAAAGATTAGCTGTCTATCTGGTACCCGATGTTCAGGCTGAACGTGGTCTGCCAAATCGGGCAGATAAAACGCTGCCCCGGAGTTTAACACTTAAATCATCAATGGTCTACTCAACGCCAAATGATAAGACTGAAGGAGTTTGGAGCGGTGGCGTTATACCCCGCGGCACACGCTTTGGCCCATTCGAAGGCATTCCAACCTCAAATTATCCAAATGATAAGAATAAGGCGCGCTATTTTTGGCGGGTGCAGGGAACACGCCACATAACCTACGGGAATATTAAGATCTTCAAGGACGATGACTATTATTATTTAGATGGTTCGGATCGTTCACAATCAAATTGGATGCGTTATGTGGCATCTGCGTATAGTTTATCGGTAATGAATCTGGTTGCCTGTCAGCATATGGAGAATATCTATTTCTATACCACACGGGATATAATGCCCAATGAGGAGCTAATGGTTTGGTATTGCAAGGATTTCGCCTCTCGTCTTGGCTACGATGTTGATCCCGAACGAACCATCTTTGGTGCCTGCAAACAGGTTGAAACCGATGAAGTTGATAGAGAAGAGGATGAAGAGTGCATGGATATGGTCGATGAGGATGATGAAGCTGCAGGCAAGAAGTCACACTACACAATGGCAGCTCCAGCAGAGATACCCGCCGAAGTGGCTGTGAGTCATATAACCTATGTGATGGGTCTGCATTTGCCAGCTAGTGCAACAGTGGCGGCCGCAGCAGCGTCATCGTCATCGTCATCAGGAACAACCACCCCAGCTTCGGCACCAGCATCAGCAGGAAGCCAATCCCAAACTCAATCCCAAGTAGCGGCAACAGCTGCCTCTGGTTGTTGCACCCATGTCAGCACGACCACATCAACGACAAATCTTCAGCCTCACATTCATCGTCATGCTTCCGTCATAATGGGTGGACAGGATCGTTCGCCTTTGAATACAAGTGACAAAGAAGAGGCTGCCCGTTCGCCGCTCTCCGCTATGATGGCCCAAGATGGCAGCGTACGTTCAGTGCGCTCCGATGAGGGTTATCACAGCAATGAGTGTCATGAGGATGGCCTTACCCCACCAGAGGACTCTAGCGATAGTGAGAGTGAACACAATTATGTGCTAGATTGTTCCAAGAAGGCCATTGCCCCCAAGGAGACGGTGATTGCTCAGGCACAGAAATCCATAAATGGCAATAAATCACCGCAAACCGTGGTCAAGAGTCCCAGCCCGCCATTGGCATTGGCACCAGTGCAAAAACATCAAACGGATGCCAATGACAAGAATGAGTATCGTAAATTCAAAGTGAAAATGCCTCTGAAATATGAAATCAAAAACAAAACCCTAAACTGTGTGAAACAAGAGCCCATCAAGGAGGTGGATGAGCTGCCACCGCATATGGTGAACGAAGATGAGGACGAGGAGCGAATGCATGCCACCTCGACATTGGGTGAGGAGCGTGAATTGACCCAACAGCAGCCGGCATCATCGACGGTCATTGTGTTGGAACAATCGAGAACCATAGTGCCGCTAACGAAACCATATTATGAAAGTGATACGCCTGCCCTGCGATTCAGTCAGCCATCGTCGAGCATATTGGAGACAATACTGACGAGTCAACATCGTTTGGAGGCCGCTGCCCGTCAAGCGAATGCCGCCACACCGCCGCCCACATCACCGACCGAGATGGCCTATAGCTATAAGAAATCTCAGCGTTATGGCAATGCTGTTAGTCCCGATTCATCATCGAATTTGGGACAAAATCCCGAATGCTTGACCAACGACCAGGAGACATTAACCCGATCGACTCTAATCAAGGGAGAATGCTCACCGCCGCCAGCTCAGCATCATCTTCAGCATCATCATCATCACCATCATCACAATGTGATCTACTCACCCCGACATGCTGCCTATCTGAATGAGGCCGGTCGCGGCGTTGTCGACGAAAGTCATCTGCATAGTGGCGGCTCACCAGGCAGCTATCCACCCTATCCACACTATGGCTCCGGATCGGCGGCCACTTCAACTTTCCATTCACCTCCGCATAGTTCGCATTCGCCATTTGATCGGCAATCGAATGCATCGAGTGGTGCCGGCTCAGCATCAAATCTTCATCTGCTCCAGAGTAGCTCACAAATGCTTAACCATCCACTGATGCAGCCATTGACACCATTGCAGAGATTATCTCCATTGAGAATATCACCACCCAGCAGTCTTAGTCCCGATGGCAATTCATGTCCACGCAGTGGCAGTCCCCTTAGTCCCAATTCATTGGCCTCACGGGGCTATCGCTCCCTGCCGTATCCCCTGAAGAAGAAGGATGGCAAAATGCACTACGAATGCAATGTCTGCTGCAAAACATTTGGGCAATTGAGCAATCTAAAGGTCCATTTACGCACCCATTCCGGTGAACGACCATTCAAGTGCAATGTTTGCACTAAGAGCTTCACTCAATTGGCCCATCTGCAGAAACATCATTTGGTACACACGGGCGAGAAGCCGCATCAGTGTGATATATGCAAGAAACGATTCTCCAGCACTTCGAATTTGAAAACCCATCTGAGATTGCATAGTGGCCAGAAGCCATATGCCTGCGATCTATGTCCGCAGAAATTTACGCAATTTGTCCATTTGAAATTGCACAAGAGATTGCATACGAATGATCGGCCATATGTATGCCAGGGATGCGATAAGAAATACATAAGCGCATCGGGATTGAGAACACATTGGAAGACCACCAGCTGTAAGCCAAATAATTTGGAAGAAGAATTGGCCATGGCAGCGGCAGCCACATCAGAGTGTTTAGATAAAGATCTCCCCGAACCCGAGACGCAGTGGCCACGCAGTGGCAGTCCCCTCAGTCCCAATTCATTGGCCTCACGGGGCTATCGCTCCCTGCCGTATCCCCTGAAGAAGAAGGATGGCAAAATGCACTACGAATGCAATGTCTGTTGCAAAACATTTGGGCAATTGAGCAATCTAAAGGACCATTTACGCACCCATTCCGGTGAACGACCATTCAAGTGCAATGTCTGCACTAAGAGCTTCACTCAATTGGCAAATCTGCAGAAACATCATTTGGTACACACGGGCGAGAAGCCGCATCAGTGTGATATATGCAAGAAACGATTCTCCAGCACTTCGAATTTGAAAACCCATCTGAGATTGAATAGTGGCCAGAAGCCATATGCCTGCGATCTATGTCCGCAGAAATTTACGCAATTTGTCCATTTGAAATTGCACAAGAGATTGCATACGAATCGGCCATATGTATTCCAGGGATGCGATAAGAAATACATAAGCGCATCGGGATTGAAAAAACATTGGAAGACCACCAGCTCAATTTCAAAGGAAGCGGAATGCGGCTGTGTGCGTTTGGGTAAATGCAAATGGTTTAATGTGGCCAAAGGATGGGGCTTTCTAACGCCCAACGATGGCGGTCAGGAGGTCTTTGTCCATCAGAGTGTCATACAAATGTCGGGATTCCGTTCGTTGGGCGAGCAAGAGGAAGTGGAATTTGAATGCCAGCGGACAGCAAGAGGTTTGGAGGCCACCAGAGTATCGGGAAAACAGGGTGACGATTGCCATGGCAGCACCTTCAGACCAAGAATCAATCGACGAACTCGCCGGATGCGTTGCTATAATTGCGGTGAATTTGCCAATCATATTGCCTCGGAATGTGGTTTGGGGCCACAGCCGAAACGTTGCCATCGCTGTCGGAGTGAAGACCATTTACATGCCGATTGCCCCCATCGCAATGTGACACAAACCTCTCAGCGACTCGGTAGTAAAAGCCCCCAAGAAGTCGATGAAGAACAATCATCATCATCATCACCTTTGACCAACTCACCGCCAACAAAGTCAACGGGTTCTTAG
Protein Sequence: MREEDFERLAVYLVPDVQAERGLPNRADKTLPRSLTLKSSMVYSTPNDKTEGVWSGGVIPRGTRFGPFEGIPTSNYPNDKNKARYFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHMENIYFYTTRDIMPNEELMVWYCKDFASRLGYDVDPERTIFGACKQVETDEVDREEDEECMDMVDEDDEAAGKKSHYTMAAPAEIPAEVAVSHITYVMGLHLPASATVAAAAASSSSSSGTTTPASAPASAGSQSQTQSQVAATAASGCCTHVSTTTSTTNLQPHIHRHASVIMGGQDRSPLNTSDKEEAARSPLSAMMAQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHNYVLDCSKKAIAPKETVIAQAQKSINGNKSPQTVVKSPSPPLALAPVQKHQTDANDKNEYRKFKVKMPLKYEIKNKTLNCVKQEPIKEVDELPPHMVNEDEDEERMHATSTLGEERELTQQQPASSTVIVLEQSRTIVPLTKPYYESDTPALRFSQPSSSILETILTSQHRLEAAARQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQNPECLTNDQETLTRSTLIKGECSPPPAQHHLQHHHHHHHHNVIYSPRHAAYLNEAGRGVVDESHLHSGGSPGSYPPYPHYGSGSAATSTFHSPPHSSHSPFDRQSNASSGAGSASNLHLLQSSSQMLNHPLMQPLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHWKTTSCKPNNLEEELAMAAAATSECLDKDLPEPETQWPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKDHLRTHSGERPFKCNVCTKSFTQLANLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLNSGQKPYACDLCPQKFTQFVHLKLHKRLHTNRPYVFQGCDKKYISASGLKKHWKTTSSISKEAECGCVRLGKCKWFNVAKGWGFLTPNDGGQEVFVHQSVIQMSGFRSLGEQEEVEFECQRTARGLEATRVSGKQGDDCHGSTFRPRINRRTRRMRCYNCGEFANHIASECGLGPQPKRCHRCRSEDHLHADCPHRNVTQTSQRLGSKSPQEVDEEQSSSSSPLTNSPPTKSTGS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -