Basic Information

Insect: Drosophila parvula
Gene Symbol: topi
Assembly: GCA_018904695.1
Location: JAEIIG010035352.1:25229-27998[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 1e-05 0.00078 19.8 1.4 2 23 252 273 252 273 0.97

2 10 0.055 4.2 8.1 0.0 2 23 299 320 298 320 0.84

3 10 4.2 3.2e+02 2.1 0.0 2 23 386 407 385 407 0.90

4 10 0.0022 0.17 12.4 0.2 1 23 454 476 454 476 0.95

5 10 7.6 5.7e+02 1.3 0.1 2 16 493 507 492 515 0.81

6 10 4.9e-07 3.7e-05 23.9 1.9 1 23 537 559 537 559 0.95

7 10 0.0002 0.015 15.7 1.0 1 23 565 590 565 590 0.97

8 10 0.6 45 4.8 1.8 1 23 596 618 596 618 0.88

9 10 1.3e-07 9.6e-06 25.8 0.6 1 23 624 646 624 646 0.99

10 10 0.0013 0.1 13.1 2.5 1 23 652 675 652 675 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	1e-05	0.00078	19.8	1.4	2	23	252	273	252	273	0.97
2	10	0.055	4.2	8.1	0.0	2	23	299	320	298	320	0.84
3	10	4.2	3.2e+02	2.1	0.0	2	23	386	407	385	407	0.90
4	10	0.0022	0.17	12.4	0.2	1	23	454	476	454	476	0.95
5	10	7.6	5.7e+02	1.3	0.1	2	16	493	507	492	515	0.81
6	10	4.9e-07	3.7e-05	23.9	1.9	1	23	537	559	537	559	0.95
7	10	0.0002	0.015	15.7	1.0	1	23	565	590	565	590	0.97
8	10	0.6	45	4.8	1.8	1	23	596	618	596	618	0.88
9	10	1.3e-07	9.6e-06	25.8	0.6	1	23	624	646	624	646	0.99
10	10	0.0013	0.1	13.1	2.5	1	23	652	675	652	675	0.96

Sequence Information

Coding Sequence: ATGGATCACGAAGATTTATCTAGCATTCTACCGGGTGAGCAGCAGGAGGGGATATATACATTGACCGAGATCGAGGTCGATATGGATTCTCAGTTGACTCCCAGTGACTTGGACCCCGGTGCTAAGGTGCTGCTCTCCATTGAGGGGGATGAAGACGGAGAACGCGTTACGGGCGCCGAAGATTTATCCAGATGGTTTGTAATAGAACAGCCCCCGAGCCCGGCACCCATATCCCCAGATGTGGTGGTGCAGCGCACCCTGGAAGATCCTGCTCTCAAGCAGATCCTCTTGACGTCCTCCGACGGTAAGCCGGACTTTGATCCCCAGGCAGAGCAGATGAAGATTCGCAGCTTTCTGGCAGGCTTTACCAATAGTAAGAGGACCACAGAGCAGCCGATATATCAAGGATATCACCCACATGGAAATGGCTTCATCAACCGGATTAAAGGCCCAGGTGCATTTAATGCCTCCTCGACCCAGAGTCATTGCAGTGGCGTCGTGGCTGATCGGAAGCTCAATCAGAAGCCCGCCGCCGTAGGGCTGACCGAGAAGCTGGTGGAGAAGCCAGTGCCAGCAAAAGTAGAATCAGCCGTTGCTCCACCTAAGCCTCCATTGCCAAGCAAACCAAACAGCTTGCGCGTGATCACGGAAAACCAGATCCGCCTGCGTCGCTTTCTGAACGATGAGCTTAAGTACGACATAACCAGCGACATGGAAGGTTCGCGCAATAGTAAGTCGGCCAAGGGACCCAACGAGTGCAGCAAGTGTGACCGCAAGTTTGTGCATGCCTCCGGTTTGGTTCGCCACATGGAGAAGCATGTCCTGGATCTAATCCCCTCACCGACCAACTCACAACCGTCCCCATCTCTAGCCGCTGGACTTATAACCGTAATAAAGTGCAACGTCTGTGGCCGGATCTTTTACGATCCGCAGGTGGCCTTGGAACACGTCGAGGTACATTTCGAGGTACAGCCCAGGAGCATACCGCCTCGTGATCGATCGAAGCTCAAGTACAAACCCAATCCAGATTTCAAGAGACTTATGAATAAAGTCGAGTTGCTGATGAGCGAAGTAAGCTTGGAAACTGAAGAGTTGAACGACCCGAACCGCCTGGAAAATAATTTGTTCAGCTGCCTGGTGCTGGGCAGTGTCCTGCAGTGTGAGTTCTGCGAAAACGTGTTCGCCGGCATCACGGAGGTGCTCGCCCATTCGGCCACTCACCTGGCAAAGCGCCGTTTCGAGTGCACCGCCTGCGACATTAAGATGCACAGTGCCAAGGAGGCCAGAATCCATTTCGAGACGGACTGCATCTTTATGCGCGAGGCGATGAAGTCGTTAAGTGTTTCGATCAGCCGCTACTTTGTGTGCAATGTGTGCGAGCTGAAGTTTGCCAATACGGAGCTGCTGCAGGAGCATCGCTATGCCCACCAACACTATTTTCCGAGGCTGAGTTCGAATGGATCGCGCCTGCTGTTGCCCTGCGAGTTCTGCGATGTGTTCTTCGAGTCCGCCCGCGAAGTGCAGCCGCACAATGAGGAGAAGCATCTTAGCAAAAAGAAGCGGGAAAAGGAGTCCCGCAACAGCACGGCCAGTGGACGCCAGCGCCAGTATCTGTGCGACATCTGCGGCAAGTCATACACCCAGTCGAGCCACTTGTGGCAGCACCTGCGCTTCCACCAGGGTGTGAAGCCATTTGTCTGCCCGGAGGAGAAATGTGACCGGAAGTTCACCATCCGACCGGACCTTAACGACCATATCCGCAAGTGCCACACGGGCGAGCGTCCGTTTCACTGTCTTGTGTGCGGGAAGCGTTTCCTCACCGGCTCCGTTTTCTACCAGCATCGCCTCATCCATCGTGGCGAGCGACGCTACGAGTGCGAGGAGTGTAACAAGCGATTCTATCGCGCCGATGCCCTCAAGAACCACCAGCGCATCCATACCGGCGAGAAACCGTTCAGCTGTCTCTTCTGCACCAAAACCTTCCGGCAGCGCGGCGATCGCGACAAGCACATGAGGGCCCGTCACTCGCACCTCGACGCCAACTCGCGCCTCATGATGCAGATGCAGAAATTCCAGCTGGAGTCGGCCGCAGCCGCCAAGGCCAATGGCGAACAGGCTCCGTCCGGCGACGCTGTGACTTCTCCTAGTAGTCCCTTTCAGGCTGAACCTTCCGAACCTGGAGAGATGGAAACTCTGGAGGAGGAACTGCGTAATTCCATTAGGTCCGAATCGGAGGAGGAAAACGTGCCCAGCTATTTTGTGGTGGAAGAGTATATGCCTTCAACGTCTATGGAAGATTTCAATATGGAGGATGGGGCCAACTCCTTTGAGCAAAAGGACTGCTCCATGGAGGAGGAGGAGCAGCAGTTAATTATGTTCGAGCCCGGACGGGATATGATGAGTTTAGAAGACGATTTGGAAACGGGACAGAATGTAATCACGTTTGACTATAAGGAGCCGGACGAGCAGCCGATGCCGGATGAGGGATACGTTTCAATTTTGCAGCGCGCCGAAAATGCCCGGGTTGTCGTTATGCAGAACAATCCAGATCAGCCTTTGTTTTCCAATTCCTACATGTAA
Protein Sequence: MDHEDLSSILPGEQQEGIYTLTEIEVDMDSQLTPSDLDPGAKVLLSIEGDEDGERVTGAEDLSRWFVIEQPPSPAPISPDVVVQRTLEDPALKQILLTSSDGKPDFDPQAEQMKIRSFLAGFTNSKRTTEQPIYQGYHPHGNGFINRIKGPGAFNASSTQSHCSGVVADRKLNQKPAAVGLTEKLVEKPVPAKVESAVAPPKPPLPSKPNSLRVITENQIRLRRFLNDELKYDITSDMEGSRNSKSAKGPNECSKCDRKFVHASGLVRHMEKHVLDLIPSPTNSQPSPSLAAGLITVIKCNVCGRIFYDPQVALEHVEVHFEVQPRSIPPRDRSKLKYKPNPDFKRLMNKVELLMSEVSLETEELNDPNRLENNLFSCLVLGSVLQCEFCENVFAGITEVLAHSATHLAKRRFECTACDIKMHSAKEARIHFETDCIFMREAMKSLSVSISRYFVCNVCELKFANTELLQEHRYAHQHYFPRLSSNGSRLLLPCEFCDVFFESAREVQPHNEEKHLSKKKREKESRNSTASGRQRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEEKCDRKFTIRPDLNDHIRKCHTGERPFHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECNKRFYRADALKNHQRIHTGEKPFSCLFCTKTFRQRGDRDKHMRARHSHLDANSRLMMQMQKFQLESAAAAKANGEQAPSGDAVTSPSSPFQAEPSEPGEMETLEEELRNSIRSESEEENVPSYFVVEEYMPSTSMEDFNMEDGANSFEQKDCSMEEEEQQLIMFEPGRDMMSLEDDLETGQNVITFDYKEPDEQPMPDEGYVSILQRAENARVVVMQNNPDQPLFSNSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00526072;
90% Identity: -
80% Identity: -