Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.5e-06 0.0001 22.6 1.3 2 23 132 153 132 153 0.97

2 6 1.1e-06 7.4e-05 23.0 2.3 1 23 159 181 159 181 0.98

3 6 0.00044 0.03 14.8 3.8 2 23 188 209 187 209 0.96

4 6 0.00027 0.018 15.5 2.7 1 23 215 238 215 238 0.96

5 6 0.0026 0.17 12.4 1.1 1 23 262 285 262 285 0.95

6 6 0.00027 0.019 15.5 2.8 1 23 291 313 291 313 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.5e-06	0.0001	22.6	1.3	2	23	132	153	132	153	0.97
2	6	1.1e-06	7.4e-05	23.0	2.3	1	23	159	181	159	181	0.98
3	6	0.00044	0.03	14.8	3.8	2	23	188	209	187	209	0.96
4	6	0.00027	0.018	15.5	2.7	1	23	215	238	215	238	0.96
5	6	0.0026	0.17	12.4	1.1	1	23	262	285	262	285	0.95
6	6	0.00027	0.019	15.5	2.8	1	23	291	313	291	313	0.97

Coding Sequence: atggtgaaagttataaacataaatataaatgcaaaatgcgcCGAAATACACTGCAACGCATCGCTAGAAGCAAACTTTCTGATCAAATGCATTTGCGGCACCTCTTCATTGGATTACGTTGCATTTCAGCGGCACTTTATTACGGATCATTTGCAGCCAGATCTCCACACTAAAGATCAGATGCTAAGAACTCCAGTAAGCCATGATGTCGATGACTCGGCGGCACCCCGAGACTGTCTAAATGAACCTGTTGTTGAGCTGCCAGTGGTTCTAGAGCCTCCAACAATCATAGAAACCGGACATGATACTCTTTCGCTTGGCGAATCCGACAGGAACGAATCATTGCCAGAGCAGCTTAAACCCCGTCCTTATAAGCCACGCAATAGATCAAACACGTGCACATATTGCGGGCGGACCTTTCGACGTCGCTATCTGCTAGACACCCACCTGAATATACACACTGGCAGCAAGCCCCACCAATGCGATATGTGTGGCAAACAGTTTCGAGCCGTCTCCACGCTTACGCGCCACCTTCGGACCCATCAGGAGCGCAAGGAACTCCAGTGCCAGCATTGCGAAAAGCTATTTACCCATCGTAGTGCCCTGCTTAGCCACGAGCTGCGGCACACACAAGTACGCCGGTTTGCTTGCACCAGCTGCGACAAGAGCTTCTACACCCGCAACCAAATGGACACCCATAGGCGCAAGATGCACGCGAACGCCAGCACACAGAGATGCCAGGACATCACAGGCAACGGTGACCAAAGTCCACCTCTATTGCCGTTTGCCTGCGAGCTGTGCAGCAACAGTTATCGGAGTGCCTCCACGCTGAGCACCCACAAGCTTAAGAAACACTATCGCCTAGCCAAATACAGTTGCGAGTCGTGCGATAAAAAGTTTATGGACGTCAATCACCTGCGACAGCACCAGTTTATCCATGTGAAGCCCCAAGTTGCAATAGAgacttaa
Protein Sequence: MVKVINININAKCAEIHCNASLEANFLIKCICGTSSLDYVAFQRHFITDHLQPDLHTKDQMLRTPVSHDVDDSAAPRDCLNEPVVELPVVLEPPTIIETGHDTLSLGESDRNESLPEQLKPRPYKPRNRSNTCTYCGRTFRRRYLLDTHLNIHTGSKPHQCDMCGKQFRAVSTLTRHLRTHQERKELQCQHCEKLFTHRSALLSHELRHTQVRRFACTSCDKSFYTRNQMDTHRRKMHANASTQRCQDITGNGDQSPPLLPFACELCSNSYRSASTLSTHKLKKHYRLAKYSCESCDKKFMDVNHLRQHQFIHVKPQVAIET

Sequence clustering based on sequence similarity using MMseqs2