Basic Information

Insect: Drosophila paranaensis
Gene Symbol: zfh1
Assembly: GCA_035047545.1
Location: JAWNPL010000173.1:10270438-10296961[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0014 0.098 13.2 1.1 2 23 73 95 72 95 0.94

2 9 0.00085 0.057 13.9 0.1 1 23 293 315 293 315 0.97

3 9 3.2e-05 0.0022 18.4 1.8 2 23 329 350 328 350 0.97

4 9 1.1e-05 0.00076 19.8 6.4 1 23 359 381 359 381 0.99

5 9 0.00033 0.022 15.2 1.2 3 21 389 407 387 408 0.94

6 9 0.03 2 9.0 0.4 2 21 631 650 630 651 0.92

7 9 1.5e-05 0.00099 19.4 0.5 1 23 1011 1033 1011 1033 0.94

8 9 5.5e-05 0.0037 17.7 7.4 1 23 1039 1061 1039 1061 0.98

9 9 0.0028 0.19 12.3 4.3 1 21 1067 1087 1067 1088 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0014	0.098	13.2	1.1	2	23	73	95	72	95	0.94
2	9	0.00085	0.057	13.9	0.1	1	23	293	315	293	315	0.97
3	9	3.2e-05	0.0022	18.4	1.8	2	23	329	350	328	350	0.97
4	9	1.1e-05	0.00076	19.8	6.4	1	23	359	381	359	381	0.99
5	9	0.00033	0.022	15.2	1.2	3	21	389	407	387	408	0.94
6	9	0.03	2	9.0	0.4	2	21	631	650	630	651	0.92
7	9	1.5e-05	0.00099	19.4	0.5	1	23	1011	1033	1011	1033	0.94
8	9	5.5e-05	0.0037	17.7	7.4	1	23	1039	1061	1039	1061	0.98
9	9	0.0028	0.19	12.3	4.3	1	21	1067	1087	1067	1088	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTTCCTCTTTGGCCTCCAGTTTGCACCACCACCAAGCCCACAACAAGCCCAGCAATGCGGCTGCCAATCCAGAGCTGGCCACCAGCGCCACAGCCAGCGCGGCTGAGGACTGCCTGGTCAAGTGCACGCAGTGCAACAAGCGCTTCACCGACTTTCAGTCCTTCAGCGAGCACATTGCCAACGAGCATCCGCATGACAAGCTCAACTATGAGTCGCATCGTGCGGCCGCTGAGGCTGCGCAGCCGGAGAGCGAGGCGGAGGAGGACGAGCAGAGCaatttgagcagcagcagtcgtcgCTATGCCAAGTCCCCaaacaccaccaacaacaacaacaacaatagcgagACAACAAAGAAtcagaataacaacaacaacaacagcagcaacagcggcagccatAGAAGCCAGCACTCACCTCTGAGCTCACCTGTGGCAGCCACGATCAACGATCTGTTTGCCCACCTGCCGCAccagccgccgcagctgcccGCCCACTTGCACGCCCAATTCATGGCAGCCGCTGCTCTGGCCATGCAGTCCGCCCAATCCGCCAGTTCgcccagccaacagcagcaccagcagcaacagcaacagcaacaacagcagcagcagcaacagctgcaacagtcgccgcagctgcagcaggctctgctgctgccgccgcctcagcccggcagcaacagcagcgtcgGCAGCAACTCCGCCTACGACCTGGACTTGAGTGCACCGCGCTCCACCTCCAGCCCGGGCTCCACAACGGGCGACCTCGGCGCCGCCTTCCCCTGCATGCAGTGCACCGCCGCCTTCGCCAGCCGCGACCAGCTcgagcagcaccagctgctgcactCGCCCACGGGCCCGCAGACCACACAGAACGTGACGCAGACCTGCAAAATATGCCACAAGGCCTTCGCGAACGTGTATCGCCTCCAGCGACACATGATCAGCCACGACGAGTCCGCACTGCTGCGCAAATTCAAGTGCAACCAGTGCGACAAGGCCTTCAAGTTCAAGCATCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTTGGCTGCGACAACTGCGGCAAGCGCTTCTCGCACTCCGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATTAGCATGGGCCTCAAGCTCAACAACAATCGCCAAATGCTCAAGACTCTGGACAAGAACTCAAGCGCCAGACGCTCGCCCAcagaccagcagcagcagcagctggcgggcAAGCGGAAGCTGTCCGAGCAGGTGCTCCCGAACCCCATGAACTACTTTGCCGGCGAAGTACAGAACTCACCAACCACAGTCAATGCTCCTGCGCCCTTCTATCCCAACTACAATGCGGCTTTGCTGGCATTCCCGAATGCCTTTATGGCTGCCGCGCTGGATCCGCGCATGCATCCCTATAGCATACAGCGGCTGCTGGAGCTGACTGCTGccgggcagcagcaacaacagcagcagcagcgggaggagcagctggagcaggagcacaGGGAGCAACAGAAGCTGTACGAGACCAGCAAGGATGATGATGAAACGCCAGATGAGCCCAAATTGGTTATGGATCTGGAGGAAGCGGAGCCCAAGCCTGCGCCCAGCCCAGAATCGCCCGTCGCTGAGACCGTAGCTATCGACGTGGGCGTCGTTAAGCAGGAGCCCAGTCGCGAGCCGACGCCTCCGGACACGCCAAAGTCCATCAAAGTGGAGCAtgaggaggagctggagccTGTGGTCGTGGAGCAGTCGCGTGCGCAGACACCTCAGGATCtgcgctgcagtcgctgcgccAAGCAATTCAACCATCCCACAGAGCTGGTGCAGCACGAGAAGGTGCTTTGCGGCCTCATCAAAGAGGAGCTGGAGCAACAataccagcagcaacatcaacagcagcagcaacaacagcaacatcaacaggagcaacaacagcaacaacaacagcagcaacaacaacaacaacagacgaGCTTTGCTCTGCTGCCGTCGGCCAGCGATGCGgacgaggatgaggaggacgaggaggagccACGCCAGGATTACCATgcaggcagcagcgacagcggcgagCGCAAGGTGCGCGTGCGCACCGCCATCAAcgaggaacagcagcagcagctcaagcaaCACTACGCCCACAATTCGCGTCCTAGTCGGGATGAGTTCCGCATGATCGCCGCCCGCCTGCAGCTGGACGCGCGCGTCGTCCAGGTCTGGTTCCAGAACAATCGCTCGCGCGAACGCAAGCTCCAGAGCTATGCGAGTAACGGCGaggctccagctgcagcagctccggcaCCACCCCAGCCACGCGCTGGCGAGGATCAGCCTCTGGATTTGTCCGTGAAGCGTGATGCTTCGCCCTTGTACGGCTTGGCGTcccagcaggcagcagtgCTGCCCGCACCCGCTGACTTTCAGGAGACAATGGCCATTAATCTGAGCCGTAAGTTGTCCGGGTCGGCGTCCATGTCGCCAGCTTCGCTGTcgccctgctcgggcgcctcCTCGCTGCAGCAGtcggcggcagctgcggctgccgctgcagcgctTTACTTTGCGCCCCCCTCGCCGCCCAGCCTGCACGAATCGGGGCCTGCGCCCGCTCCGCGTGGCCAGGGATTCGCCGGGCTGCCGCCCTACATGCTGCCACGCCTGCCCATGGAGGCACTCTTCCAGATGCGGCCCGGCGGTGACTATGCGCCCAATCCGCTCATGAACAGTATTAAGCTGCCCGACTATCGCGGCACCAGCCTTAGTCCCGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGATGATTCGCGCATCTCGCATGACGATGACTACGTCCTGGCGAACGGTGGCCTACTGCCGCCCAAGCCCAAGCGGACCAAGGCCGAAACGCACGGACACGCAGGTGATCCGGACTTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAACAGAGTTCCCTGGCGCGCCACAAGTACGAGCATTCCGGTCAGCGACCCTATCAGTGCATGGACTGCCCGAAGGCTTTCAAGCATAAGCATCACCTGACGGAGCACAAGCGTCTGCATTCCGGCGAGAAGCCATTTCAGTGTTCCAAGTGCTTGAAGCGATTCTCCCACTCGGGCAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFSSLASSLHHHQAHNKPSNAAANPELATSATASAAEDCLVKCTQCNKRFTDFQSFSEHIANEHPHDKLNYESHRAAAEAAQPESEAEEDEQSNLSSSSRRYAKSPNTTNNNNNNSETTKNQNNNNNNSSNSGSHRSQHSPLSSPVAATINDLFAHLPHQPPQLPAHLHAQFMAAAALAMQSAQSASSPSQQQHQQQQQQQQQQQQQQLQQSPQLQQALLLPPPQPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLGAAFPCMQCTAAFASRDQLEQHQLLHSPTGPQTTQNVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCNQCDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRQMLKTLDKNSSARRSPTDQQQQQLAGKRKLSEQVLPNPMNYFAGEVQNSPTTVNAPAPFYPNYNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQQQQQQREEQLEQEHREQQKLYETSKDDDETPDEPKLVMDLEEAEPKPAPSPESPVAETVAIDVGVVKQEPSREPTPPDTPKSIKVEHEEELEPVVVEQSRAQTPQDLRCSRCAKQFNHPTELVQHEKVLCGLIKEELEQQYQQQHQQQQQQQQHQQEQQQQQQQQQQQQQQTSFALLPSASDADEDEEDEEEPRQDYHAGSSDSGERKVRVRTAINEEQQQQLKQHYAHNSRPSRDEFRMIAARLQLDARVVQVWFQNNRSRERKLQSYASNGEAPAAAAPAPPQPRAGEDQPLDLSVKRDASPLYGLASQQAAVLPAPADFQETMAINLSRKLSGSASMSPASLSPCSGASSLQQSAAAAAAAAALYFAPPSPPSLHESGPAPAPRGQGFAGLPPYMLPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHDDDYVLANGGLLPPKPKRTKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00530857;
90% Identity: iTF_00559678;
80% Identity: iTF_00568150;