Basic Information

Insect: Drosophila ochracea
Gene Symbol: topi
Assembly: GCA_035044125.1
Location: JAWNML010000021.1:13523228-13524892[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 2.7e-05 0.0017 18.6 2.5 1 23 214 237 214 237 0.98

2 8 0.0022 0.14 12.6 0.8 1 20 276 297 276 300 0.94

3 8 1e-06 6.3e-05 23.1 0.5 3 23 305 325 303 325 0.97

4 8 0.0041 0.26 11.8 0.2 1 19 331 351 331 353 0.97

5 8 4.3e-05 0.0027 18.0 1.5 2 23 362 383 361 383 0.96

6 8 0.00015 0.0094 16.3 0.5 2 23 390 411 390 411 0.95

7 8 0.00014 0.0087 16.4 0.5 1 23 417 439 417 439 0.96

8 8 2.9e-08 1.8e-06 28.0 0.5 1 23 445 467 445 467 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	2.7e-05	0.0017	18.6	2.5	1	23	214	237	214	237	0.98
2	8	0.0022	0.14	12.6	0.8	1	20	276	297	276	300	0.94
3	8	1e-06	6.3e-05	23.1	0.5	3	23	305	325	303	325	0.97
4	8	0.0041	0.26	11.8	0.2	1	19	331	351	331	353	0.97
5	8	4.3e-05	0.0027	18.0	1.5	2	23	362	383	361	383	0.96
6	8	0.00015	0.0094	16.3	0.5	2	23	390	411	390	411	0.95
7	8	0.00014	0.0087	16.4	0.5	1	23	417	439	417	439	0.96
8	8	2.9e-08	1.8e-06	28.0	0.5	1	23	445	467	445	467	0.99

Sequence Information

Coding Sequence: ATGATCAAATTGCAGCCACCAACTCCAGACTGCGGCcgaacatatttcaattttcgttGCGGCGAAGTGCTGTGCCTGGGCCCCACCAGCTACGATGTCTGTTGTGCGCTATGCGGCCAGCGGTTGCCATTTGATGGATTTCCACAACATTTTCGGCTGGAGCATCTGACCGAGACAAAGATTGAAGACTGCAAGCTGTTCAATGGACAGGATGCAGAGGAACAGCAACTGGAAGCACCAGTGCTGGAGGTGGACGTTGAGCCGCTGGCTATCAAGTTTGAGGATGATCCCATAGCACACGATGAGGCTGCACACGAGTCCAATGAACATGTGCACGTTGATTTGGCTCAGATAGCGCTGCTCGACGAGGAGCACGAGACTGATAAGGATGCACATAATGCTGCCCTATCTACTGCACCTGCTAAAGATTCGAATGATGACAATAGAACAATTGCAACGCGTCGACAACAACGGAAAGCGGCCCTAAAAAATGTGCTTGTCCAGCGATCAGAAACGCTTCTGGACTGGatggcagcatcagcaacggTAGACGGCAGCGATGCCCAATGTCTCGAAGTCAATGGGGATTCGGCAACGGATGCCAACGATGAGGAAGAAGACGACACCAGGGACATGCTCTTCCAGTGTGATCAATGTGAACGCGCATACAACACCAAGCGCAGCCTGCAGAGCCACAGACGTAGCAAACACAATGTGCGCAAGCCAACAAAATCAGCACAGCACAGGATTGCCACAGATCTACCCATTATGCCGTCACCAGGAAGCAGCGTGCGCCGGCGACAGAGCAAGGGACCGACGAGGATCTATAAATGTGATGAGAGCGAATGCAATCAGACATTTCGCACGGAGCGCGATTTGCGTGGCCATCGATGGAAGCATACGGGCATCTTTTGCGATATTTGCGGCAAGCCATTCACGCAGTCGGGGAATATGATGCGTCATCGTCAGCGGCATAGTGGGATCAAGCCATACAAGTGCCAGGAGGCCGATTGCGAGGCGACATTTTACACCCAAAAGGAGCTGACATCGCATAACATTTGCCACACGGGCCGCATGCCGTGCATCTGTGAGGTGTGCGGTCGTCCATGTCGGGATCGTGGCGTCCTCACTGCCCATATGCGACGACACACTGGTGAACGGCCGGCGAAGTGTGAGGTATGCGGCAAGGCATTCTATAGCTTCCATGACCTCAACGTGCACGCTGTCTCCCACACGAATCTGCGGCCGTTTGTCTGCGATGTTTGTGGCTCCACATTTCAGCGAAAGAAGGCGTTGCGCGTCCATAAACTCCTGCACTCCGAGCAGCGTAAATATTCGTGTAAGCTGTGCAACAAATCCTTTGCACAATCCGGCGGACTAAATGCCCACATGCGCACCCACGAATCGAATCGAGCCAATCGGTCGAAAGGCATTGCCAAAGCGGACACCATCACAACTACGTCCACAGTTCAGCTGGAAATTCCCATCGAAATGGATGACGACGTCAACAACGATGAGGATGACGTtgacgataatgatgatattgatgatgatgatgacgagaTGGTGCAGGAGGCGGTAACCATTGAGCTGATACAGGAGGAGAATGCCTCACATGTGGAAGTTGTTACCGTCGCCGCTGCAGGCAGCTGGCATCAAACATAA
Protein Sequence: MIKLQPPTPDCGRTYFNFRCGEVLCLGPTSYDVCCALCGQRLPFDGFPQHFRLEHLTETKIEDCKLFNGQDAEEQQLEAPVLEVDVEPLAIKFEDDPIAHDEAAHESNEHVHVDLAQIALLDEEHETDKDAHNAALSTAPAKDSNDDNRTIATRRQQRKAALKNVLVQRSETLLDWMAASATVDGSDAQCLEVNGDSATDANDEEEDDTRDMLFQCDQCERAYNTKRSLQSHRRSKHNVRKPTKSAQHRIATDLPIMPSPGSSVRRRQSKGPTRIYKCDESECNQTFRTERDLRGHRWKHTGIFCDICGKPFTQSGNMMRHRQRHSGIKPYKCQEADCEATFYTQKELTSHNICHTGRMPCICEVCGRPCRDRGVLTAHMRRHTGERPAKCEVCGKAFYSFHDLNVHAVSHTNLRPFVCDVCGSTFQRKKALRVHKLLHSEQRKYSCKLCNKSFAQSGGLNAHMRTHESNRANRSKGIAKADTITTTSTVQLEIPIEMDDDVNNDEDDVDDNDDIDDDDDEMVQEAVTIELIQEENASHVEVVTVAAAGSWHQT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00500482;
90% Identity: iTF_00576512;
80% Identity: -