Dobs005892.1
Basic Information
- Insect
- Drosophila obscura
- Gene Symbol
- zfh1_4
- Assembly
- GCA_018151105.1
- Location
- NW:5552174-5579695[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 0.00075 0.046 13.9 1.2 2 23 75 97 74 97 0.95 2 9 0.0019 0.12 12.6 0.1 1 23 311 333 311 333 0.96 3 9 0.0001 0.0064 16.6 1.7 2 23 348 369 347 369 0.97 4 9 5.1e-06 0.00031 20.7 6.3 1 23 378 400 378 400 0.99 5 9 0.0003 0.018 15.1 1.2 3 21 408 426 406 427 0.94 6 9 0.0085 0.52 10.6 1.8 2 21 676 695 675 696 0.92 7 9 1.3e-05 0.00082 19.4 0.5 1 23 1053 1075 1053 1075 0.94 8 9 5e-05 0.0031 17.6 7.4 1 23 1081 1103 1081 1103 0.98 9 9 0.0025 0.15 12.2 4.3 1 21 1109 1129 1109 1130 0.96
Sequence Information
- Coding Sequence
- ATGTTGTCCTGCCTGGCGCCGTCGTCTACACGTTTTGGCCAAGAGGATAACAGCATAATACAGCAGAGCATGCCATCGTCCACAGCCTTCACCATGCAGTTTCCCTCTTTGGCTTCCAGTCTGCACCACCACCAGGCACCGCACAGCAAGCCCAGCAATGGCTCCGGTGGCAGCCAGGAGCAGCACGCACAGCCCGGTGTCTCCGTCGATGATTTCCTGGTCAAGTGCCCGCAGTGCCACAAACGCTTCACCGAGTTTCAGTCCCTCAGCGAACACATCGCCAGCGAGCATCCGCACGATAAGCTGAACTTCGAGGCAAGTCGCGGCTCCAGCGGTGCCGTGCAGCCCGAGAGCGATGCCGAGGACGAGCAGAGCAATCTGAGTGGCAGCCGGTACGCCAAGTCCCCGGCAACCACCAGCCATGCCACcccaagcagcaacaacaacaacaacaacaacaacagcgaacTGGCCAAGaaccacaacagcagccacagcaacggcAGTAAGCTCTCGCCCATATGCTCGCCCGGATCGGTGGGTCCCGCCGCAGATCTCTTCGCCCACCTCTCACACGGAGCCCCGCCCCAGCTGCCCTCCCACCTGCACGCCCAGTTcatggccgccgccgccctgGCCATGCAGTCGGCCCGATCCGTCAGCTCCTCCGCCAGTTCGCCCAACAGCCACcatcatcaccagcagcagcagtcgcaccatcaccaccagcagcaccaccagcagcagcacctccaccaacagcaacagtcgcaacagcagcagcagcagatggccatccagcagctgctgccgccacaaCTGCCGGGAAGCAACAGCAGTGTGGGCAGCAATTCCGCCTACGATCTGGACCTGAGTGCCCCGCGGTCCACCTCCAGTCCGGGCTCCACCACCGGCGATCTGAGCGGCGCCTATCCCTGCATGCAATGCACCGCCGCCTTCAGCAGCCgcgagcagctggagcagcacgAGCTCCTCCACTCGCCCACCGGGGGCCAGCCCACGGCACAGAATGTCTCACAGACTTGCCGAATCTGCCACAAAGCCTTCGCAAATGTCTACCGCCTGCAACGGCACATGATCAGCCACGACGAGTCGGCGCTGCTGCGAAAATTCAAGTGCAAGGAGTGCGACAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGTTTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGGGCGCTGCTCAAGCGACTGGAGAAGAGTCCTGGCGCCGGGCCCCGACGCTCGCCCACGGACCTGCAGGGCCCCAAAAACGGTGCCGGAAAGATGTCCGATCAGCAGTCCCTGCCTCCGCTGCCCAATCCCATGATCTACTTTGCCGGCgaggcgcaggcgcaggctGCCGCTTCGAATGGAGCTCCTCCACCGTTCTATCCAAACTACATGAATGCGGCCCTGCTGGCCTTCCCCAATCCCTTCATGGCAGCGGCCCTGGATCCCCGCGTCCACCCCTACAGCATACAGCGGCTCCTGGAGCTGACAGCTGccggacagcagcaacaacaacaacaacagcagcagcagcagcatcagcgcgAGGAAcgcgaggagcaggagcagcacgaAGAGCCTGAGACGCCGGAGGAGCCCAAGCTGGTCATGGACATTGATGAGGCAGAGGCCAAGGAGCGTATGGTGCCACACGCGAGCCCGCAAACCATGCCAGAGGAGATCGAACCCGTTGTCGCCATGGCCACTGCTCCCATCAAGCAGGAGCCTAGCCGCGAGCCCACCCCACTCCCGGAGAGTGCACCGCCCACGCCCAAGTCCTTCAAGCAGGAGCAAGAGGAGCCCCGTTGCCTGGAAGAGGATCAGCCCATGGAATCGGCTCAACCCGAAGCCTCTGTCTCCTCCCCAAGGGACACACCCGTCGAGCTGCGGTGCAGCCGCTGCGACAAGCAGTTCAATCACCACACAGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATCAAGGAAGAGCTGGAGCAGCActaccaccagcagcagcaacagcagcagcaccaacagctccagcagcatcagcagcagcaggcatcCTTTGCCCTGCCCTCGGCCAGCGAggatgacgaggaggaggaggagcgcgAGAACGACAACGACACGGAGCAGCGTCCGGACAGCAACGAGCGTAAGGTGCGCGTCCGCACGGCCATcaacgaggagcagcagcagcagctgaagcagcaCTACGCCCTCAATGCGCGGCCGAGTCGCGACGAGTTCCGAATGATTGCGGCCCGCCTCCAGCTGGATCCGCGCGTGGTCCAGGTCTGGTTCCAGAACAACCGCTCACGTGAGCGGAAGATGCAAAGCTATGCGACGGCAGCTCCAGCCGCCAATGAAGTGCCCAATACTCCGGTGGCCAGCCGTCCCACAACCGAGGATCAGCCCCTGGATCTGTCCGTGAAGCGCGACTCCTTGACGCCCAAGAGCGACCACTCCGCCGTGTACGGATTgccccagcagcaggctgCCGGACAGCCAGCCCCCGCCGACTTCCAGGAGGCCATCAACCTGAGTCGCAAGTTCTCCAGCTCGGCCTCCATGTCGCCAGCCTCGCTGTCGCCCTCGTCGGGCGCCTCTCTGCAGCAATCCTCGGCAGCTGCGGCCGCCGCTGCGGCAGCCCTCTGGCCCTTTGGCGGCCAGCCTCCATCGCCGCCCAGCCAGCACGAGGCCACGCCCGCCCAGCACTGCTCGACGCCGCGCGGTGGCCAGGCCTTCCCGGGACTCCAGTACATGCTGCCAATGCAGCGGCTACCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATAAACAGTATTAAGATGCCCGACTTCCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGACTTCGGCAACGGCTTGATGCCGCCCAAGCCACGCCGCGGCAAGGCAGAGACCCACGGGCATGCCGGGGATCCGGATCTGCCATTCGTCTGCGACCAGTGCGACAAGGCGTTTGCCAAGCAGAGCTCCCTGGCGAGGCACAAGTACGAGCATTCCGGTCAACGACCATACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCACAAGCGTCTGCACAGCGGGGAGAAGCCCTTCCAGTGCTCCAAATGCCTGAAGCGCTTCTCGCACTCGGGAAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCCTACAGGGAATAG
- Protein Sequence
- MLSCLAPSSTRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKPSNGSGGSQEQHAQPGVSVDDFLVKCPQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPATTSHATPSSNNNNNNNNSELAKNHNSSHSNGSKLSPICSPGSVGPAADLFAHLSHGAPPQLPSHLHAQFMAAAALAMQSARSVSSSASSPNSHHHHQQQQSHHHHQQHHQQQHLHQQQQSQQQQQQMAIQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFSSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGAGPRRSPTDLQGPKNGAGKMSDQQSLPPLPNPMIYFAGEAQAQAAASNGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQQQQQQQQQHQREEREEQEQHEEPETPEEPKLVMDIDEAEAKERMVPHASPQTMPEEIEPVVAMATAPIKQEPSREPTPLPESAPPTPKSFKQEQEEPRCLEEDQPMESAQPEASVSSPRDTPVELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQQQQQQHQQLQQHQQQQASFALPSASEDDEEEEERENDNDTEQRPDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYATAAPAANEVPNTPVASRPTTEDQPLDLSVKRDSLTPKSDHSAVYGLPQQQAAGQPAPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGQPPSPPSQHEATPAQHCSTPRGGQAFPGLQYMLPMQRLPMEALFQMRPGGEYAPNPLINSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKPRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00603548;
- 90% Identity
- iTF_00563802;
- 80% Identity
- iTF_00563802;