Basic Information

Insect: Drosophila obscura
Gene Symbol: NFYC
Assembly: GCA_018151105.1
Location: NW:1354571-1357659[+]

Transcription Factor Domain

TF Family: NF-YC
Domain: NF-YC domain
PFAM: AnimalTFDB
TF Group: Other Alpha-Helix Group
Description: Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [1]. CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' [2], seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1 1.4e+04 -14.2 24.3 134 209 50 126 19 146 0.54

2 5 4.1e-47 6e-43 147.0 16.3 19 234 150 371 146 375 0.68

3 5 1 1.4e+04 -16.6 71.0 141 271 374 522 367 523 0.69

4 5 1 1.4e+04 -26.0 47.6 156 260 505 601 504 609 0.67

5 5 0.12 1.7e+03 -2.1 8.4 205 234 616 645 611 647 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1	1.4e+04	-14.2	24.3	134	209	50	126	19	146	0.54
2	5	4.1e-47	6e-43	147.0	16.3	19	234	150	371	146	375	0.68
3	5	1	1.4e+04	-16.6	71.0	141	271	374	522	367	523	0.69
4	5	1	1.4e+04	-26.0	47.6	156	260	505	601	504	609	0.67
5	5	0.12	1.7e+03	-2.1	8.4	205	234	616	645	611	647	0.81

Sequence Information

Coding Sequence: ATGTACGCGACCAACAATGGCGGCACAAATAAGGCGCCAAACAGCAATGCCTCCACCACGCTGTTCGACAACACAATCACCGTGACACCGATCAAGATGGATCTGAGCGGGCCCATGACGCAGGCCTACGCAGCTGGCAAGGTAACGACGGCGGTTCAGCGACGAACGCCCAACGCTGTGGTTGTCACATCCCAACAGCAACTGCCCCAGCAGCTTTcccagcaacaccagcagcagcagcaacaacagcaacaacagcagcagcttcaacAATCTGCCGCGGCCACGCTGACGATGCCCATGCAGGCGACGCTGGTGTCTAGCGCCTGCACCATTGTGAATCCCGGAATGACAATGACGGTCaatgccagtcccagtccgagCACGCCCAAGGAGAAGGCCACGAAGGCGACACGGACGCAAGTGGCACGGAAACCGCCGCCGACCATCGAAAACTTCTGGCCGAACATCGTGAGCGATGTGCACGGGATCGGGCAGGTGGATGCGAAGCACCAGGTTCTGCCCTTGGCGCGCATCAAGAAGATCATGAAGCTGGACGAGCACGCCAAAATGATAGCGGGTGAGGCACCGCTGCTCTTTGCCAAGGCCTGCGAATACTTCATCCAGGAGCTGACCATGCACGCCTGGGTGCACACCGAGGAGAGTCGCCGGCGCACGCTGCAGCGCTCGGACATCGCCCAGGCCATAGCGAACTACGATCAGTTCGATTTCCTCATCGACATAGTGCCGCGGGAGGAGATCAAGCCCTCGTCGGCGCAGAAGGGAAAAGATGCAATGGGAGCGTGCTCAACGACGGGTATGGCCGGGTCCGTTGCCGGCGGTTCTGTTGGccacagctcctcctcctcctccgccgccacAGCAACCGCCACGAGCAACTACAGTTTGGGCGGCACCTCTGTACCTTCTGCCACGGCCACCATCAAGATGGACACCAGCAGCGCTGCGACCGCAGCCGAGGTGCTCGGCTTCAGCACCGTCAATCAGGATATTTTCACCgcccaactgcagcagcatcaacaccagcaacagcagcagcatcagcagccccAGCACGTGCAGATCATCCAGCAGGCCGGTGGCCATGCGGgcggccagcagctgcagtaCTTCATTGCGCTGCCGGGCCAGCAGGGGACGCAGCTGGTCCAGCAAgtgcagcaggtgcagcagcagccagctcaAAATCACTTGTCCCAGAGTCTCGGGCTCAACATTGTGGCCGCGCAGCAGCCCACACAGCAGCTGATCCTCACCACCGgccccaatgggcagttgacCGCCACTCCGGCGCCGGCAACGGCAGCCCAGCAGCAAACGGCCCTGCTACAGAATCTCGcccagcagcatcaccagcagcaacagcagcaacaacaacagcagcagcaacagcaacaaatccAGATAATTCAGCAGGTGGTGGGCCCAACGGGAGAGATATCCAATGTACCCATTGCCATCACTGCGAGCCACTTGCAGCTGCTGCGACTGCagatgcagcaacagcagcagcaacaacagcagcagcagcagcaacaagtcGCCGCCGCTGCACAATTGGCTGGGCAGCAGcatggccaacagcagcaggtgaTAATACCCACAAACCTGCTGACGGCACAGCAGCTCATTCAGCTGGGGGCCTCGCCAGCGGGCACAGccacccaccagcagcagcatcatcatcagcagcagcagcatcatcaccagcagcagcatcagattCAGGTGCAggtacagcaacagcagcatgtTAATCTCAGCCAGAGCAACTCCAGCACCGTCAGCAATGCCACGCCCATATACATCAACTCAACGGTATCGAGTGCGCAGACGGCAACGCAgtcgcaacagcagcagcaaacgcaGGCGCAGACGATCACCACAATGTCTACGGATCGGACGCTGACTGGAGGGTTTCGGTAA
Protein Sequence: MYATNNGGTNKAPNSNASTTLFDNTITVTPIKMDLSGPMTQAYAAGKVTTAVQRRTPNAVVVTSQQQLPQQLSQQHQQQQQQQQQQQQLQQSAAATLTMPMQATLVSSACTIVNPGMTMTVNASPSPSTPKEKATKATRTQVARKPPPTIENFWPNIVSDVHGIGQVDAKHQVLPLARIKKIMKLDEHAKMIAGEAPLLFAKACEYFIQELTMHAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSSAQKGKDAMGACSTTGMAGSVAGGSVGHSSSSSSAATATATSNYSLGGTSVPSATATIKMDTSSAATAAEVLGFSTVNQDIFTAQLQQHQHQQQQQHQQPQHVQIIQQAGGHAGGQQLQYFIALPGQQGTQLVQQVQQVQQQPAQNHLSQSLGLNIVAAQQPTQQLILTTGPNGQLTATPAPATAAQQQTALLQNLAQQHHQQQQQQQQQQQQQQQIQIIQQVVGPTGEISNVPIAITASHLQLLRLQMQQQQQQQQQQQQQQVAAAAQLAGQQHGQQQQVIIPTNLLTAQQLIQLGASPAGTATHQQQHHHQQQQHHHQQQHQIQVQVQQQQHVNLSQSNSSTVSNATPIYINSTVSSAQTATQSQQQQQTQAQTITTMSTDRTLTGGFR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00580709;
90% Identity: iTF_00574794;
80% Identity: -