Dnig004236.1
Basic Information
- Insect
- Drosophila nigromelanica
- Gene Symbol
- Hsf
- Assembly
- GCA_004149445.1
- Location
- SCDR01000292.1:39761-43566[-]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 1.1e-36 1.4e-32 112.7 0.1 1 100 48 147 48 147 0.97 2 2 2 2.7e+04 -3.9 0.3 67 85 572 590 564 601 0.51
Sequence Information
- Coding Sequence
- ATGTCCAAAACGCGTGCAAGCCTTAAAGCCGTGCAACTCAAGCACGAATCAACCGAAGAAGAGGAGGACGACGaagaccagcagcagcgaccacGTCGCAATATGCATACAGTTGGTGAAACTGGGAGCGGGGTGCCAGCCTTTTTGGCTAAGCTCTGGCGCCTCGTTGAAGATCCGGATACAAATGGTTTAATTTGCTGGAGCAAGGATGGCCGTAGTTTCATCATACAAAATCAAGCGCAATTCGCGCGCGAGCTTTTGCCATTGAACTACAAGCACAATAACATGGCTAGTTTTATAAGACAATTGAATATGTATGGATTTCATAAGATCACCTCCATAGAAAATGGCGGCTTGCGATTTGATCGCGATGAGATTGAATTTTCGCATCCGTGCTTCAAGCGCAATTATCCGTATCTATTGGATCACATCAAGCGCAAGATATCCAATACGAAGAGTGTGGATGAGAAGAGCGTGCTGAAGCAGGAGACCGTCTCAAAGGTGCTCAGCGACGTGAAGGCTATGCGCGGCCGTCAGGACAACTTGGACTCACGTTTCTCGGTGATGAAACAGGAGAACGAGGCCCTCTGGCGCGAGATAGCTTCGCTGCGTCAAAAGCacgcaaagcagcagcagatagtCAACAAGTTGATACAGTTTCTAATCTCAATTGTGCAGCCGTCGCGCAACATGTCCGGCGTTAAGCGTCACATGCAGCTGATGATTAACGATACGCCGGAAAATGCTCGCAAGCGCAATGCAAGCGAATCGGAAAGCGAAGGCGGCCCAGTCATACACGAGCTGAGCGAGGAGCTGCTCGACGAGGTGATGAACCCACACAGTCCCTATGCCAAGCAGTACGATGGCGAGAGCGTCTCTCCGCTGGCCGTGGAGCGACCACGCTCCAACATGAGCATCACCAGTTCGCAAAATTACGATTACTCGAATCAGAGCGCCGAGGATTTCATTGCTGCTCAGCTTTTGCATAGCGCTGGTGAAGCTAGTGCCACCAATGTGGCTCGCTCGCCGGGCGGTGGCCAACAAGTGCTTTATACGGTCACCGAAGCACCCGATTCGCATGtccagcaggagcagcacaTGCAACCCAGTCCCAACAGTCTCCACAATAGCGATGAGCAGCTGAACGTGCTCACCACGCCCATGGTGCGCGAGCAGGAGGCGCGCAATCGTCAGCTGCTGAAGGAGAAGAACAAACAGCGTCGCAATGCAGACATTATTGGACAGGTGGATTTGGACATGTCGCCAAAGTCTTCGCGTACACGCTCGCAGACCAAGGATCAGTCGCAGGTCACGGTTATGCCGCAGCCGGTGCTGGTCAAGACGGAGCCGGAGCTGAGCAACGTGACGGGCGGCAGCATGCCAATCCTGTTAGATCAACCGGAGTCCACTAATGCCGATCTGTACAATGTCAACTTTATAAGCAACGATATGCCAACGAATATCTTCGAAGATGATTCGTTGATGTCCAGCGCAGGCATGGATGAACAAGCTACCAAGCTggatcaacaacagcagtttgGACGCTCCACTGTGAACAGCGGAAAGTTTGCCAATGTGCCGATCAACTTTGACTTGTCCagtaacaatagcaacaacaatgagaaccCTTTGCTAACCGATGCGAATTTGGCATCCACCTCaaaagcggctgctgctgtcaatgATATCAACgatgaacaacagcaacaacaacagaaacagcagcaacaacaacaagcaatgaCCGTGGCCAAATATACAGGCGACAATGTAGCCGAGACACATGATGAGGTCAGCGGTCATTTGGAAAATATGCAAGATGAGCTTGACACACTCAAGGATCTGCTCCGCGGCGAAGGGGTTTCTATTGATCAGAACATGCTCATGGGCGCTGCACCGAAGGTCGTTGCTGCCAGGATGCCTGTTTTGCAGCTGACCGACGAGGAACTCCTACTGAAGCTCTTTAATGATTCAGATGTGTTGGATAACTATGGCCTATCTTTTCTAAATGACATGGGCGGCGATAAGAAAGCGAGCAGCGGCTCTGAGCTAATGGCCTATCAGCCCAATATGTATGATCTCTCGGACATTTTGGACACGGACGATAACAAGGCTAGCCAGGATACGGCCAATGGGCGCCAATTGCAGACCCAAAGCTCTGTGCTAAATACGCCGCGCCATGATTTGTAG
- Protein Sequence
- MSKTRASLKAVQLKHESTEEEEDDEDQQQRPRRNMHTVGETGSGVPAFLAKLWRLVEDPDTNGLICWSKDGRSFIIQNQAQFARELLPLNYKHNNMASFIRQLNMYGFHKITSIENGGLRFDRDEIEFSHPCFKRNYPYLLDHIKRKISNTKSVDEKSVLKQETVSKVLSDVKAMRGRQDNLDSRFSVMKQENEALWREIASLRQKHAKQQQIVNKLIQFLISIVQPSRNMSGVKRHMQLMINDTPENARKRNASESESEGGPVIHELSEELLDEVMNPHSPYAKQYDGESVSPLAVERPRSNMSITSSQNYDYSNQSAEDFIAAQLLHSAGEASATNVARSPGGGQQVLYTVTEAPDSHVQQEQHMQPSPNSLHNSDEQLNVLTTPMVREQEARNRQLLKEKNKQRRNADIIGQVDLDMSPKSSRTRSQTKDQSQVTVMPQPVLVKTEPELSNVTGGSMPILLDQPESTNADLYNVNFISNDMPTNIFEDDSLMSSAGMDEQATKLDQQQQFGRSTVNSGKFANVPINFDLSSNNSNNNENPLLTDANLASTSKAAAAVNDINDEQQQQQQKQQQQQQAMTVAKYTGDNVAETHDEVSGHLENMQDELDTLKDLLRGEGVSIDQNMLMGAAPKVVAARMPVLQLTDEELLLKLFNDSDVLDNYGLSFLNDMGGDKKASSGSELMAYQPNMYDLSDILDTDDNKASQDTANGRQLQTQSSVLNTPRHDL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00530871;
- 90% Identity
- iTF_00547276;
- 80% Identity
- -