Basic Information

Insect: Drosophila nigricruria
Gene Symbol: topi
Assembly: GCA_037075265.1
Location: JBAMCI010000160.1:7664954-7667472[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 6.7e-05 0.0048 17.4 1.3 2 23 244 265 244 265 0.97

2 10 0.011 0.82 10.4 0.5 2 23 293 314 292 314 0.92

3 10 0.039 2.8 8.7 0.1 2 23 376 397 375 397 0.96

4 10 5.7 4.1e+02 1.9 0.1 1 22 403 424 403 424 0.88

5 10 0.019 1.4 9.7 1.2 1 21 444 464 444 468 0.90

6 10 5.1e-07 3.7e-05 24.1 1.9 1 23 530 552 530 552 0.95

7 10 0.00052 0.038 14.6 1.1 1 23 558 583 558 583 0.96

8 10 0.45 32 5.4 1.7 1 23 589 611 589 611 0.88

9 10 3.9e-08 2.8e-06 27.6 0.4 1 23 617 639 617 639 0.99

10 10 0.00073 0.052 14.1 1.2 1 23 645 668 645 668 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	6.7e-05	0.0048	17.4	1.3	2	23	244	265	244	265	0.97
2	10	0.011	0.82	10.4	0.5	2	23	293	314	292	314	0.92
3	10	0.039	2.8	8.7	0.1	2	23	376	397	375	397	0.96
4	10	5.7	4.1e+02	1.9	0.1	1	22	403	424	403	424	0.88
5	10	0.019	1.4	9.7	1.2	1	21	444	464	444	468	0.90
6	10	5.1e-07	3.7e-05	24.1	1.9	1	23	530	552	530	552	0.95
7	10	0.00052	0.038	14.6	1.1	1	23	558	583	558	583	0.96
8	10	0.45	32	5.4	1.7	1	23	589	611	589	611	0.88
9	10	3.9e-08	2.8e-06	27.6	0.4	1	23	617	639	617	639	0.99
10	10	0.00073	0.052	14.1	1.2	1	23	645	668	645	668	0.95

Sequence Information

Coding Sequence: atggaTCCCAATTTAGTGTTATACGGAGATGGTGAGTTCCTAATGGCTGAATTCGAATTCGATGGCGATTTGGTTGTGAATAGTGATGAACTGCAGCCGGGTGCTACTGTGCTGGTGTCCAATGAGACAGATGGCATTGTTAGCCATGAGGACTTGGCCAAGCTCTTTGAGATACAGTCGGGCATGCCGATGCCCACAGAAGAGGCTGTGGAGCGCACACTGGCTGACCCGGCTTTGAAGCAGATCCTGCAAGAGGTTGATGGCAAGGTGGATTTTGATCCCGAGGCTGAACAGGAAAAGTTACGCGAGTTCCTCTCGGGAGTCAACAATAAGAAGACAGTCCCGGAGAAAGCTGCCGCAACAGctgaggctgtggctgtggctgcggctcaAAAGCAGCTGTCGGTGTCTCAGCTACGACCTGCAATACCGCAATCAACTGTCTTTCGCTTCATCAAGTGCTCCAATTGCAATGGGCTCTTTGACACGTCCTCATTTCAGGATCACAGCTGTGAATACGAGTCAGAGCAAAAATCATCGTCCACTAGTCGAGCACCAACAGTTCAGGAGAAGAAGCCATCCACGCCACCCAGAAAGACGCCCAGCGAACGTATCATCGTTGAGAACCAAGTGCGCATACGTCGCTATATGAAAGACGAGCTTAAGTACGATCTAGAGACGGGCTTCGACAGCTCCAAGTCTAAGAAGGCCAACACCAAGGGTCCCAACGAGTGCAGCATCTGCGAGCGAAAATTTGTGCACACCTCTGGCTTGGTTCGTCACATGGAAAAACATGCACTTGACCTTATCCCCACACAGACGAACATCCAGCAACAGCACGTGGCTCCCTCGTCACTGGGGCTATTGGTGGTACTTAAATGCAACCACTGTGGCCGGATCTTCTACGACGTCAAACTGGCGCTCGAGCACATCTTTGTGCATCAGTCGACAACGGACGTAGCTGAGACCGAACCTATGATTGAGGATGAAGCATTAATGAAGAGTCAGCTGGAACAGCTCATGCTGGAGGGCGAGCAACTAATCTCTCTTACCGCTGAACTGGGCAGGATGTCGCTCAAGAATGAGGATGAATACTTTACCACGCTTGTCCTCAGCAATGTGCTGCAGTGCGAGTTCTGCGATTTTATCTTTGCGGATGTGTCCTTCTTGCTGATGCACTCGGCCACACATGTGCCGGAGCGTCGCTTCGAGTGCACCTCCTGTGATTTGCGAATGACCACCGCCAAGGAGGCCAGTGTCCACTATCAGACAGACTGTGTCTATATGCGTGAAGGCCTCAAGCAGCTGCAGGCGCAACCGAATCGCTTCTTTGTGTGCAACGTGTGCGAGCTGAAGTTCGCCAATGTGGAGCTGCTCCAGGAGCATCGCTATAGCTGCTATCACTACTTTCCTCGGCTCAGCGAGAGCGGCAAGCGCCTGGTGCTGCCATGCGAGTTTTGTGCCACAAACTTTGAGTACGCGCATGAGATACAGCCACACTATGAGGAGAAGCATCTGAATAAGAAGAAGCGCGAGAAGGAGCTGCGTAACAGCGGAAACGGAACCACCATGGGCCGTTTGCGACAATATCTATGCGACATTTGCGGCAAGTCCTATACACAGTCCAGTCATTTGTGGCAGCATCTACGTTTCCACCAGGGTGTGAAGCCGTTCGTTTGCCAGGAGGAGAACTGTGGCCGCAAATTCACCATACGCCCAGATCTCAACGATCACATTCGTAAATGCCACACGGGTGAGCGGCCGTATCATTGCCTCGTCTGTGGCAAGCGCTTTCTTACCGGCTCGGTCTTCTATCAGCATCGGCTCATACATCGGGGAGAGCGCCGGTACGAGTGCGATGAGTGCGGCAAGCGTTTTTATCGCGCTGATGCATTGAAGAACCATCAGCGTATTCACACCGGCGAGAAGCCCTACGATTGTCCATTCTGCACCAAGACGTTCCGGCAGCGCGGCGATCGAGATAAGCATGTGCGTGCACGCCACTCGCACTTGGACGCAAATGCACGGTTGAtgatgcaaatgcaaaagttCGAATTGGAAACGGCAGCTGCACTGAAGGCCAAGCAAATGCAAGAGGGCGGCATTGAATTTGTGGTTGATTCGGGGGCAGAAACGGCTATGCATTCGCCAACATCTCCCATAGCGCATGATCAACAGTTTGATATGGTTGAATTGGATCCCAGCGATTTTGGCGATGCCTCCGAGTATGTGCAAAGTATTCCAATGCCTCTCAGTAATGAGGAGCAAGAGCTTATGTCGTATGCGCACCTAGAGGGAACAGACCAAATCGAGCAACAGGCATTCCAGTTAGAAAACAGCGAAAATGTTAAAGTTGTTGTGGTTGAAAATAATACCTCGCAACCGTTTTACttctaa
Protein Sequence: MDPNLVLYGDGEFLMAEFEFDGDLVVNSDELQPGATVLVSNETDGIVSHEDLAKLFEIQSGMPMPTEEAVERTLADPALKQILQEVDGKVDFDPEAEQEKLREFLSGVNNKKTVPEKAAATAEAVAVAAAQKQLSVSQLRPAIPQSTVFRFIKCSNCNGLFDTSSFQDHSCEYESEQKSSSTSRAPTVQEKKPSTPPRKTPSERIIVENQVRIRRYMKDELKYDLETGFDSSKSKKANTKGPNECSICERKFVHTSGLVRHMEKHALDLIPTQTNIQQQHVAPSSLGLLVVLKCNHCGRIFYDVKLALEHIFVHQSTTDVAETEPMIEDEALMKSQLEQLMLEGEQLISLTAELGRMSLKNEDEYFTTLVLSNVLQCEFCDFIFADVSFLLMHSATHVPERRFECTSCDLRMTTAKEASVHYQTDCVYMREGLKQLQAQPNRFFVCNVCELKFANVELLQEHRYSCYHYFPRLSESGKRLVLPCEFCATNFEYAHEIQPHYEEKHLNKKKREKELRNSGNGTTMGRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYDCPFCTKTFRQRGDRDKHVRARHSHLDANARLMMQMQKFELETAAALKAKQMQEGGIEFVVDSGAETAMHSPTSPIAHDQQFDMVELDPSDFGDASEYVQSIPMPLSNEEQELMSYAHLEGTDQIEQQAFQLENSENVKVVVVENNTSQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00475441;
90% Identity: iTF_00532592;
80% Identity: -