Dnig001326.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila nigricruria
Gene Symbol
wdn
Assembly
GCA_037075265.1
Location
JBAMCI010000035.1:4923624-4926430[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.00019 0.014 16.0 0.5 1 23 305 327 305 327 0.98
2 7 0.06 4.3 8.1 1.8 2 23 338 358 337 358 0.93
3 7 6.4e-07 4.6e-05 23.7 1.1 1 23 364 386 364 386 0.99
4 7 4.1e-06 0.00029 21.2 4.0 1 23 392 414 392 414 0.98
5 7 0.00021 0.015 15.8 3.0 1 23 420 442 420 442 0.97
6 7 5.2e-06 0.00037 20.9 0.8 1 23 448 470 448 470 0.96
7 7 9.6e-05 0.0069 16.9 2.3 1 23 476 499 476 499 0.98

Sequence Information

Coding Sequence
ATGGAGTGTAAAGGCAAATcaaagagaatgaaagaagAGGCGCCAAGCAAAAAATTGCCGCCTAAAATATATGGCGGCGACTATGCGGCTAATGCAAGCACACCCACCAAAGCGGCCCACGATGAGATCCTCAGCTCGCTGCTACGCATTAACAATTTTGACTCCATATCGAGCATTAAGGACGAATCCTTGGACATCGATCTGTCCGCATGTGTGACAATCAGCTCGGCGAGCTTCATCAATGGCAATAGCCTCTCCTCAACTGACTTTTGGCGCGTACTCGATGAGAGCGCCCAAAACAACACCGAGCTCAATTTGGCCGCCGATGTATGTCGCGACGATTTGACTGCCCCCAGTCCAAACCCCAGTCCCAGTGCAAGTCCCAGTGCGGTGAACGTGGCAAACCTTTCGAATGGCAGTGCCAGTGATAACACTAATTCAGAATTTAATGTTACCTTCTTGAGGCCGGAGCCGCCAAATGCGTTTACCAATTCGCCGTTCAAGAAGATATCAACGACGCCAGTGAAGGTACCGTCACCTGAACAAGTGGCTGGCCAGACACAGCGAAAGCTTCGATTACCAGCGGCCACAGCGGTGCGCCTGAAGGTGTTCAAGGAAGAACCAGTCGAGGAGAAGCCAGCGTCGGTGGAGACCACAAAAGCTCCAGTACAGACCAAAGTGGAGATCTGTGAGGCGGAGCACACGCCGCATACGTTTACAATattccaacagcagcaggagcaaccGAATGAAATGCCACCACCAGCAGCTCCGCTAGACAATAGTGCTaaactggagctggaggcTATGCCGCAGCCCCTCTACAAGTGCCTAGACTGCAATAGTTTGGTCTTGGACAATCCGCAACTGGTGAACGCACATAAGGCAGCTGCTCATCGTCTGCGCATCACATACAATTGCTCCGAATGTCAGCGTGAGTTCGAGCTGTTGGCGGGACTCAAGAAGCACCTTAAGACGCATCGCAGTGAGGGCCGCAAGGATACATGGAAGAAGTGCCCGGACTGTGGCAAATGCTTAAAACTGGGCAGCATGTGGATGCATCGCAAGATACACAGCGACAACAAGAAGTACCAGTGCGATATCTGTGGCCAGAAATTTGTGCAGAAGATCAATTTGACGCATCATGCCCGCATTCACTCCTCGGAGAAACCGTACGAATGTCCCGAATGCCAGAAACGATTTCAGGAGCGTTCGCATCTGCAGCGTCATCAGAAGTATCATGCCCAGACGCGCTCCTATCGCTGTGAGAAATGCGGCAAAATGTACAAAACCGAACGCTGCTTGAAGGTGCACAATTTGGTGCACTTGGAGCAGCGACCATTTGCTTGCACCGTGTGCGACAAGAGCTTCATCAGCAACTCGAAGCTGAAACAGCACTCGAATATTCATACGGGCATGCGTCCTTTCAAGTGCAACTATTGTCCGCGCGACTTCACCAACTTTCCCAACTGGCTGAAGCATACCCGACGTCGCCACAAAGTGGACCACAAGACTGGCGAACATCTCGAGAACATTCCCTCCTACTGTTCAAAGAAGTCGACAACAACCAAGGCACAgaaggcggcagcagcagcagcggcagctgccgccgctgcagcagcaacaacaacgcccaCAGAGGAGCCACAGGTTGGAGCTGATGCAGAAGGGCAGCAGCCCAGCAGAGAACCAGCCAAGCCGACAGTTAGTAATGCACCTACGCCAGCGGCAAAGCAGACACGCAAAAagaaacagccacagcaagcTACATTGGCCGCTTTGGGCATCACATTGCCAGCAGGCACTGCATTGCAGCAGGTGCATCCGCTGCCCGTACGCAAAGTGgcgaatgctgctgctggggtGGCGGCGTCACCACAAGCcacgccaccaccgccgccgtcACAGTCGCCGTCTGCTTTGCCCGCCAAGCAACTGAAGACTAAGCGGGAACGCAAGCAACTGACACccaagcagctgcaacagaaGCCAGCTGCAGGCCCAACATTGTCCGTTGCCGTGCCGCAGATTAAGAAGGAGCCGCTGCAAATACAGAGTCCCTATCTAGATCTGAACGGCCTGAGCCTGACATCAGCCGAGGACCTGATCATGGAACAGGCCCTGGAGATGGAGGAGAGCGGGATGTTTGTTCCGACCGTTGTCAATACCGACATTGGCACCTCAGACAATGCCATCTCCTCAGAGGCAGCCGCCGCCCTGCACTTTCAAGTTAAAAACGAAATACCCGATGAACTCTTAGCTGACGAAGATTTCTTGCCCCATAAGCCCGTCAATGGCAATCGATTGGCCTGTCCTTCGCTCGAGTCATCGCCGTTCTCTTCGCCCGCGTCCATGGAACTGGCAGTTGTCTCCTCCAGCAACACAACCAGCTCGACTGCAACACATGTGAACACTGGTCGTGCCACCAACTACTATTTGCCTGCCTTTACATTAAATGCACAGGGCAAGCTGACTAGTTGCACGAGCACTGGAGCGGGCAGCATGGGTCTGAGCTCTGGACCTACCCAGGTGTCGATGGTGCCGCTCTTGGTGCACTCGAATCAAATATTACCCTCGGTGGATACACTGCTGTTTACCACACAGCCAGGCAATCGATTTTTCTCCGGCAAGGCAGTCGCTGGCACACAAGCAGCgtcagctgccacgccccatcTGACATGA
Protein Sequence
MECKGKSKRMKEEAPSKKLPPKIYGGDYAANASTPTKAAHDEILSSLLRINNFDSISSIKDESLDIDLSACVTISSASFINGNSLSSTDFWRVLDESAQNNTELNLAADVCRDDLTAPSPNPSPSASPSAVNVANLSNGSASDNTNSEFNVTFLRPEPPNAFTNSPFKKISTTPVKVPSPEQVAGQTQRKLRLPAATAVRLKVFKEEPVEEKPASVETTKAPVQTKVEICEAEHTPHTFTIFQQQQEQPNEMPPPAAPLDNSAKLELEAMPQPLYKCLDCNSLVLDNPQLVNAHKAAAHRLRITYNCSECQREFELLAGLKKHLKTHRSEGRKDTWKKCPDCGKCLKLGSMWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGEHLENIPSYCSKKSTTTKAQKAAAAAAAAAAAAAATTTPTEEPQVGADAEGQQPSREPAKPTVSNAPTPAAKQTRKKKQPQQATLAALGITLPAGTALQQVHPLPVRKVANAAAGVAASPQATPPPPPSQSPSALPAKQLKTKRERKQLTPKQLQQKPAAGPTLSVAVPQIKKEPLQIQSPYLDLNGLSLTSAEDLIMEQALEMEESGMFVPTVVNTDIGTSDNAISSEAAAALHFQVKNEIPDELLADEDFLPHKPVNGNRLACPSLESSPFSSPASMELAVVSSSNTTSSTATHVNTGRATNYYLPAFTLNAQGKLTSCTSTGAGSMGLSSGPTQVSMVPLLVHSNQILPSVDTLLFTTQPGNRFFSGKAVAGTQAASAATPHLT