Basic Information

Insect: Drosophila nigricruria
Gene Symbol: ham
Assembly: GCA_037075265.1
Location: JBAMCI010000150.1:11193537-11209281[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.49 35 5.2 0.0 2 21 185 204 184 207 0.87

2 9 0.0099 0.71 10.6 1.6 1 23 214 237 214 237 0.91

3 9 1.5e-07 1.1e-05 25.7 1.7 1 23 243 266 243 266 0.96

4 9 3e-07 2.1e-05 24.8 1.5 1 23 272 294 272 294 0.97

5 9 7.5e-05 0.0054 17.2 3.8 1 23 300 322 300 322 0.97

6 9 0.0016 0.12 13.0 2.0 2 21 330 349 329 350 0.94

7 9 5.8e-09 4.2e-07 30.2 1.3 1 23 827 849 827 849 0.99

8 9 3.1e-07 2.2e-05 24.8 0.9 1 23 855 878 855 878 0.97

9 9 3.9e-05 0.0028 18.1 6.8 1 23 884 906 884 906 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.49	35	5.2	0.0	2	21	185	204	184	207	0.87
2	9	0.0099	0.71	10.6	1.6	1	23	214	237	214	237	0.91
3	9	1.5e-07	1.1e-05	25.7	1.7	1	23	243	266	243	266	0.96
4	9	3e-07	2.1e-05	24.8	1.5	1	23	272	294	272	294	0.97
5	9	7.5e-05	0.0054	17.2	3.8	1	23	300	322	300	322	0.97
6	9	0.0016	0.12	13.0	2.0	2	21	330	349	329	350	0.94
7	9	5.8e-09	4.2e-07	30.2	1.3	1	23	827	849	827	849	0.99
8	9	3.1e-07	2.2e-05	24.8	0.9	1	23	855	878	855	878	0.97
9	9	3.9e-05	0.0028	18.1	6.8	1	23	884	906	884	906	0.98

Sequence Information

Coding Sequence: ATGCCAGTTAGCACAGTTATGCACATTAGCAGACAACAGATGGCGCCAGCAGTAATTGCCGGCCCGCTCTTCCACGGCTGGCTGGAACCCTCGGCGGATGTGGCCACATGGCTAAAAAAAATACGCAACGCCCCGAACGATGAGGCTGAAGAGGCTAATTTAAGGAATTTCGTCGTGGATCGCTGTCTGTGGTACGAAACGAAACGGGATATTAGCGCTGGCGCTGAAATTGTGGTCGATGCGCGCTCCCGCGCGCCCTACGACATCAGCGACAGCCTGAGGaatggcagcagcggcagcagcaacagcgcagcggcagcagcagcagcaactgcagcagcagcagcagcagccgctgccgccgccgcagccgcCATGGCAGCggctagcaacaacaacaacaataataataacaataacaatagcgATGATCGCAGCGATCGTGATAATGGCTTTTATAGCGGCGACGAATTTGCCAAGGATAAGAAAAACCTATCGATAATTAGTCAGGGCGATAACGATTTCACAGACGACGAGAACGGTTTCGATATACGCTGTGAGGTCTGTGATAATGTCTATACGGATTTAGAACGCCTGGATGATCATCTGGTGGGCGCGCATCATTTCAAACGTGGAGAATTCGCCTGCGAGCTTTGCCCTCAACATTTCTGCCATCGTCCATTGCTGATCAAACACGGAGCGATCGCACATAACAATATAAGGAAATATTCCTGCGAGAACTGTTCCAAGGTATTCTGTGACCCATCGAATTTACAGCGTCATATTCGCGCCTATCACGTCGGCGCTCGCAGTCATCCGTGTCCGGAGTGCGGTAAAACATTCGCCACATCGTCCGGCTTGAAGCAGCACCAGCACATCCATTCCTCGGTCAAGCCGTTCGCCTGCGAGGTGTGCTTCAAGGCGTACACGCAGTTCTCTAACCTGTGCCGGCACAAGCGCATGCACGCCGACTGTCGCATGCAGATCAAGTGCAAGAAGTGCAACACGAGCTTCAGCACGGTCACATCGCTCTCCAAGCACAAGAAGTTCTGCGACAGCTCCGACAGCTTTCGCAGCAGCCAACAGAGTCgcctgcaacagcagcagcagcagcaccaccagcagcacgCGTCGCATCAGCAACAGTCGCAGTCGGGGCAACTTCTCTTGCCACCGGGTGCTCATCAACGActcgctgccgccgccgccgctgccgcagccagcagcaacagcaacgacacaGCCGCCATGGCAACGCCTCCGAATCACATGTTTACGATGCATCCCTCGCACTCCTTCTTTCCGGGCTTTCCGCCGTATGCCTTGCCCAACTTCTTTACGAACTGCCGGCCACagccgttgctgccgcacatGTTTCCCAATCCGCATCTGGGCGACATGGGCCGTGGACTGGTGGCGCCGCTTGTCTCACCGAACGCTGCcttccagcagcagctgcaggcaGCCATGAGCCTGAAGTCGGACTCGCCGCGCCTCAAACGCGAGTCCAGCACGCCGGAGCGCAAGCCCATCAAGGCCGAGCTGCAGCCCAGCGACGATGAGGAGGAAGAGGAGTCCAATTCCTATGATCAGCTGCAAATGAAGCTAGATTCGAGCAAGGAGTCCAACAAGCTAAAGTCGGAGTCAAAGACGGAAGCTAGCGGCCCACAGCCAGCAGAGCATGAGGATCATGATCATGAtcatgatgataatgataatgagaatGATATTGACAATGATAGGAAATCCATTGACATAATGAGCACACCACCGCCCGCTGAAACGGagctgcagccgcagcaggATAAAAGCAGCGTTGACCTACTGCCTCTGGATCTGTCAATCAGTCGCAAGCGACGCAGTTCATTGTGCACGGCCAGCACACCCGTTCCGCTGGCCATTTCACTGTCCAGTCGCACGTCCACGCCCGCCCTGGAGATAGCAGAGGGAGCTGCTGGGCAGCCGCCCATCAAGCTGATGAAGCACAGCTCCGGCGAATCGTCCACCTCGCATCAGTCCTTCAAGGGCAGCAGTCCCACGCCGAGTGTTAGCGCCTCGCCTGGACCCACGCCCTCGCCCTCGCCGCCCATCAGCACTGGCGGCGAGCTGAGCAGCATGTCCGAGAGTGCGGCGTCTGCTGCCGTGGGCGCTGCctcggcggcggctgctgctgcatcggTAATGGCCTGTCCGCGGCAACTGCAtccacagctgctgctcgAGGAGCTCTATCGCTCACGCTTCAATACGCCACCGTTTCATTTTTTAGGCCAAATGGGCGGACGGCCAGGTTTTGAGCCACTCAAATCGCCGGCTGCTGTCATCAGCAGCGGTAGCAGCTCGCGTCATCTGCCGTTTCCGCCCGAGCACAATTTCCATGAGGCTCTACGAGCCGCCGGCCtagccgccgccgctgccaatGCCTGCAGCAGCGGCGCCAGCGTCGGCGCCACCAACGGTGGCAAGCTCAAGGATCGCTACACCTGCAAGTTTTGCGGCAAGGTATTTCCGCGCTCCGCCAATCTCACCCGGCATCTGCGCACCCACACGGGCGAGCAGCCATACACGTGCAAGTACTGCGATCGCGCCTTCAGCATCTCCTCGAATCTGCAGCGACACGTGCGCAACATCCACAACAAGGAGCGTCCGTTCCGGTGTCACATGTGTGATCGCTGCTTTGGCCAGCAAACGAATCTCGATCGGCACCTGAAGAAGCACGAAGCGGATGCGGGCGGCTTTGAGTACAACGACTCGCCCAGTTCGAATGAGGCGAACGATCGGGAGGAGGCCTGCTTCGATGACATACGCTCCTTTATGAAGCGCGTCTATACGCCCACGAGTCTGGGCGGCGCGGATGGCGATACCGAGGAGTATGCGGGCAGCGATGATCAGTTGTCCGTGTCGACGCGTCACTCCGTCAATTTTGACAAGGAGCTGCTGGctaatggcaacaacaacaacaacaacagcaacaacactaacaacaacaacaacaacagcagcaacagcagcaccaccaccaacaacaacaacaacaatcagacAGGTCTGGGCGAAACGATCGCCGTCAGCACTTAG
Protein Sequence: MPVSTVMHISRQQMAPAVIAGPLFHGWLEPSADVATWLKKIRNAPNDEAEEANLRNFVVDRCLWYETKRDISAGAEIVVDARSRAPYDISDSLRNGSSGSSNSAAAAAAATAAAAAAAAAAAAAAMAAASNNNNNNNNNNNSDDRSDRDNGFYSGDEFAKDKKNLSIISQGDNDFTDDENGFDIRCEVCDNVYTDLERLDDHLVGAHHFKRGEFACELCPQHFCHRPLLIKHGAIAHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARSHPCPECGKTFATSSGLKQHQHIHSSVKPFACEVCFKAYTQFSNLCRHKRMHADCRMQIKCKKCNTSFSTVTSLSKHKKFCDSSDSFRSSQQSRLQQQQQQHHQQHASHQQQSQSGQLLLPPGAHQRLAAAAAAAAASSNSNDTAAMATPPNHMFTMHPSHSFFPGFPPYALPNFFTNCRPQPLLPHMFPNPHLGDMGRGLVAPLVSPNAAFQQQLQAAMSLKSDSPRLKRESSTPERKPIKAELQPSDDEEEEESNSYDQLQMKLDSSKESNKLKSESKTEASGPQPAEHEDHDHDHDDNDNENDIDNDRKSIDIMSTPPPAETELQPQQDKSSVDLLPLDLSISRKRRSSLCTASTPVPLAISLSSRTSTPALEIAEGAAGQPPIKLMKHSSGESSTSHQSFKGSSPTPSVSASPGPTPSPSPPISTGGELSSMSESAASAAVGAASAAAAAASVMACPRQLHPQLLLEELYRSRFNTPPFHFLGQMGGRPGFEPLKSPAAVISSGSSSRHLPFPPEHNFHEALRAAGLAAAAANACSSGASVGATNGGKLKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYTCKYCDRAFSISSNLQRHVRNIHNKERPFRCHMCDRCFGQQTNLDRHLKKHEADAGGFEYNDSPSSNEANDREEACFDDIRSFMKRVYTPTSLGGADGDTEEYAGSDDQLSVSTRHSVNFDKELLANGNNNNNNSNNTNNNNNNSSNSSTTTNNNNNNQTGLGETIAVST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00568407;
90% Identity: iTF_00493810;
80% Identity: -