Dnig014753.1
Basic Information
- Insect
- Drosophila nigricruria
- Gene Symbol
- lz
- Assembly
- GCA_037075265.1
- Location
- JBAMCI010000206.1:2015013-2033254[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 1.1e-70 3.2e-67 224.1 0.0 5 129 199 323 195 323 0.98 2 3 1.7 4.7e+03 -2.8 0.0 26 60 347 382 343 391 0.71 3 3 0.78 2.2e+03 -1.7 0.0 26 48 420 442 413 465 0.72
Sequence Information
- Coding Sequence
- atgcatttccatttgcccagcgaggcggcaacagcaactgcagcaacaacaacaacgattgTCAGCAGCCTCAACAGCTACTATACGGGcgcaattgcaattggaaCAGGAGCGATCCCGGCTGCGGCAcccgtcagcatcagcagcatcaacagcatcagcagcatcaacagcatcaacagcaacagcagcagcatcatcgaCGGCGGCAATCGCAGCATGGTCACATCATCGGCATCGCCAACGGGTACGGGCTGGTCAGCGCCAGCGGAATACAAGAGCGCCAATACggctgttgccgctgcagcGGGCTCAGCGGCTGCTGCGATCATGTGCGAGGTGTTGCCGTCGAGCAGTGCCAGTGTTGGCAGCAGTTCGCCAACAGGTGGCGCCAGCAATGGCACTGCCAACAGTGCCaacagtggcagtggcaataaaatcaatatcaacagcagcagcaacaacaacagcaacaacaacaacactagcaacaataacaataacaacagtcgcaacaacaacaacaacaacaacaatagcaacaatgcAGTGCATCAGGATTTGCTGTGGATGGAAAGATTTGTGCTCGAGCGACAACAGGAATATCCCGGTGAATTGGTGCGTACCAGCAATCCGTACTTCCTCTGCTCCGCCCTGCCCTCCCATTGGCGCTCGAATAAAACTCTGCCGCTGGCCTTTAAAGTCGTCGCCCTGGCGGACGTCGGCGATGGCACCTATGTGACCATCCGGGCGGGCAACGACGAGAACTGCTGCGCCGAGCTCCGCAACTATACAGCCCAGATGAAGAACGGCGTGGCCAAGTTCAATGATCTGCGCTTCGTGGGACGCAGTGGTCGAGGAAAGAGCTTTACGCTAACAATTACCGTTGCAACAAGCCCGCCACAAGTTGCCACCTATGCCAAAGCCATCAAAGTGACCGTTGACGGTCCCAGGGAGCCGCGCTCCAAGACAAGTCCACCCGGCGGTCCACAATATCGCGCCCTTGGCCTGGGCCAGCGACCATTTATCGACGGTTTCCCAAAAACTTTTCACGAACTGGAAACGCTGCGACACTCGGCAAAGGTGGCGGCTGCCacaacggcagcggcggcggctgcggtGTCGGTTGCATCGGCTGGCAATGCGCTGACCACAAACGCGAGCATTGCCCAGCAATTGGGTAGCAATTACTCATCGTCAAATAGTACAATAAATTCGGATTGCCAGGGCTACAAGCCTAATGCGCCACAAATTCAAGCCACCACCTGGCGGGTAGTTGCTAGCTGGGCACTTGTATTTCGTGTCTGGAAGCTCAGCTCCACTCTGCTCTGCTCCTTAATGAGCTACAAGATGGCGCTGACAAACGAATGCTGTGAGAACCTGAAACGGGGTCGCTGCCAATCCGAGCCCGAGCTCGAGCCCGAGCCCTGGGCCCTGGGCCCTGGGCCGGAGCTTTAA
- Protein Sequence
- MHFHLPSEAATATAATTTTIVSSLNSYYTGAIAIGTGAIPAAAPVSISSINSISSINSINSNSSSIIDGGNRSMVTSSASPTGTGWSAPAEYKSANTAVAAAAGSAAAAIMCEVLPSSSASVGSSSPTGGASNGTANSANSGSGNKININSSSNNNSNNNNTSNNNNNNSRNNNNNNNNSNNAVHQDLLWMERFVLERQQEYPGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPPGGPQYRALGLGQRPFIDGFPKTFHELETLRHSAKVAAATTAAAAAAVSVASAGNALTTNASIAQQLGSNYSSSNSTINSDCQGYKPNAPQIQATTWRVVASWALVFRVWKLSSTLLCSLMSYKMALTNECCENLKRGRCQSEPELEPEPWALGPGPEL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00599357;
- 90% Identity
- iTF_00516029;
- 80% Identity
- -