Basic Information

Insect: Drosophila neotestacea
Gene Symbol: ZNF574
Assembly: GCA_035044365.1
Location: JAWNMD010000334.1:39332-41552[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.014 1.1 10.1 0.5 2 23 330 352 329 352 0.96

2 10 2.4 1.9e+02 3.0 0.2 6 23 362 379 362 379 0.97

3 10 7.5e-05 0.0058 17.2 0.5 1 23 385 407 385 407 0.98

4 10 1.4e-05 0.0011 19.5 0.5 1 23 417 440 417 440 0.94

5 10 0.00029 0.022 15.4 0.9 1 23 448 471 448 471 0.97

6 10 1.9e-05 0.0015 19.1 1.1 3 23 479 500 477 500 0.92

7 10 0.0067 0.52 11.1 0.4 2 23 512 534 511 534 0.97

8 10 9.1e-05 0.0069 17.0 3.1 1 23 541 564 541 564 0.93

9 10 2.5e-06 0.00019 21.9 1.2 1 23 570 592 570 592 0.98

10 10 5.9e-05 0.0045 17.6 1.4 1 23 598 621 598 621 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.014	1.1	10.1	0.5	2	23	330	352	329	352	0.96
2	10	2.4	1.9e+02	3.0	0.2	6	23	362	379	362	379	0.97
3	10	7.5e-05	0.0058	17.2	0.5	1	23	385	407	385	407	0.98
4	10	1.4e-05	0.0011	19.5	0.5	1	23	417	440	417	440	0.94
5	10	0.00029	0.022	15.4	0.9	1	23	448	471	448	471	0.97
6	10	1.9e-05	0.0015	19.1	1.1	3	23	479	500	477	500	0.92
7	10	0.0067	0.52	11.1	0.4	2	23	512	534	511	534	0.97
8	10	9.1e-05	0.0069	17.0	3.1	1	23	541	564	541	564	0.93
9	10	2.5e-06	0.00019	21.9	1.2	1	23	570	592	570	592	0.98
10	10	5.9e-05	0.0045	17.6	1.4	1	23	598	621	598	621	0.97

Sequence Information

Coding Sequence: ATGACTGCCTGTGTGCTTTGTTTTGGATGCTGCAAGCTCGGCGAGtcctataaaatattttccgaAGCAGGCTTGCGGCTGAATATttgcaaaacaataaacaaacatttttggctTGAGTTGAGCAGCACGGGTGGCGAACATGAGGAAATTTGCCATCAATGCTGGGAGTGCGTTGCTAACTTTAATGTATTTTACCAACGCGTCTACAATGCGCACCAGGAACGACGCGAAGTAAAAAATGTTCCCATCGAGTTCTGTGTTGACCCGGAGGCGACTAATCCGCTTGCCTTCGGAGCGGAATTGGATGCACTGGATGAGGATTTCTTCGCATCTAACAACGTCAAGGTAGAGGTAAATGAGTTGGAACCATTGCCAAAGCTTGAAATGCTCGAGGAGGCCGTGATTGAAGAAACAAAAGCTACAAAACGCGCCTGTGTCGATAATACAGCAAATGCAAAGCGACGCATTAAAAAGGAGCGATTGACTATCGCTAGTGATTCCGATGGGGATGTACCACTGGCTGAATTCCTCGACCTAAAAAAGGTTGGCAAACCATTGGCTTTAGGAGATGATCAGACGCTCGGAAAAGGAAGACAATTGCGTAGGAGCTCTCGACGTGGGTGCAGAGCGAAAACACCATCCGAATCACCACCAAGAAAGTTAAAGAAGGAGTTCTTTTCTGACGATGAGCATGATAATGACAATGATATTGATTTCGTGGCACCCGAAGCAGTGCTAGGCACCGATGACAGTGAGAGTTCTAGTGAGAGCAGCGATAGCGATTCTGGAGACAGTTTGCCCGACATTGAGCCAGAGGAGCGCTACGCAGAGATTCCTAAGCGCGTTGTAGTCAAGCCTAAGAAGTACCGCAAACGTGTCAAGCCATTGGTGCCGCCCGTCCGTATGAGTCGGGAGGAAATTGAAAAGCGGAAAGCACAACAAACTGAATACGACGAGATTATATTTGACTTTTTCAAGAAACTGCCATGCCACATATGCAATCTGCTGGTGCCGAATTTTGGAGATATGCGACGGCATCAGCGCATGTCCCACAATCTGGAAAGCGGATTTATATCTTGTTGTGGTCGCAAGTTCCATATACGTAAGGGTCTAGCTGAACATGTGCTTGTCCATAAGAATCCTGAGCACTTTATGTGCACCCAGTGCGGTCGGGTTTTCCAGGAGTCCAAAGCTCTGGAGACCCACGAGCAAACGCATACAAATCCTCAGACAGAAAAAACCCTTTATCCGTGTGAAAAGTGTCCCAAGTCGTTCACTACAAAAGCTGCTTTAGAATATCACAATCTATCGAAGCATGTACCCAAGTCGGACTTTAAGTACAGCTGTCCCGAGTGCAACAAGAAGATGCCTACGGCCCGTAAACTAAAGCAGCACCTGCGCTATATGCACGACCCGGAGAGTGCCATCATCTGCGATAAGTGCGGCAAAACATTGCGGACTCAGGCGAATCTCAAGAAGCATCATGAGCTGGAACATTCTGATGCGCCACGTCCTAAGCCAGATCCAGTGCAATGCGAGATATGCGGAACATGGTTACGCCACATGTCCGGCCTCAAGCAGCACATGAGCACCGTTCACGAACCACCAGGAACCGAGCATCGTTGTCCCATCTGCGACAAGAAATCCACGAACGCACGAGCACTTAAACGTCACATTTACCATAACCATCAATGCGAGAGAAAGTTCCGTTGTACCATGTGCGAGAAGGCCTTCAAGAGACCACAAGATTTGAGAGAGCACACATCCACGCACACAGGTGAGGTGTTGTATACCTGTCCCAACTGTCCGCAAACATTCTTCTCGAATGCCAACATGTACAAGCATCGCCAGCGATTACATCGCGCTGAATGGGAGGCGGATCGCAAGAAACCGTTGCCACCCAACATAATGAAACAGGCGGTTGGCGCCACGTCGGCATTAAAGAAGCGACATTCCGACAATTCCGGCCCAGGACTTTTTGGACAAACCATTGACCTTGCTGCGAATATCCACAAGCAGGAGCCACAACTGCaatag
Protein Sequence: MTACVLCFGCCKLGESYKIFSEAGLRLNICKTINKHFWLELSSTGGEHEEICHQCWECVANFNVFYQRVYNAHQERREVKNVPIEFCVDPEATNPLAFGAELDALDEDFFASNNVKVEVNELEPLPKLEMLEEAVIEETKATKRACVDNTANAKRRIKKERLTIASDSDGDVPLAEFLDLKKVGKPLALGDDQTLGKGRQLRRSSRRGCRAKTPSESPPRKLKKEFFSDDEHDNDNDIDFVAPEAVLGTDDSESSSESSDSDSGDSLPDIEPEERYAEIPKRVVVKPKKYRKRVKPLVPPVRMSREEIEKRKAQQTEYDEIIFDFFKKLPCHICNLLVPNFGDMRRHQRMSHNLESGFISCCGRKFHIRKGLAEHVLVHKNPEHFMCTQCGRVFQESKALETHEQTHTNPQTEKTLYPCEKCPKSFTTKAALEYHNLSKHVPKSDFKYSCPECNKKMPTARKLKQHLRYMHDPESAIICDKCGKTLRTQANLKKHHELEHSDAPRPKPDPVQCEICGTWLRHMSGLKQHMSTVHEPPGTEHRCPICDKKSTNARALKRHIYHNHQCERKFRCTMCEKAFKRPQDLREHTSTHTGEVLYTCPNCPQTFFSNANMYKHRQRLHRAEWEADRKKPLPPNIMKQAVGATSALKKRHSDNSGPGLFGQTIDLAANIHKQEPQLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00610837;
90% Identity: iTF_00583883; iTF_00608623;
80% Identity: -