Basic Information

Insect: Drosophila neotestacea
Gene Symbol: zfh1_2
Assembly: GCA_035044365.1
Location: JAWNMD010000623.1:2351867-2357754[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.9e-05 0.0022 18.5 1.0 1 23 149 171 149 171 0.97

2 15 0.0017 0.13 13.0 1.8 3 23 179 199 177 199 0.94

3 15 9.6e-05 0.0073 16.9 0.1 1 23 359 381 359 381 0.98

4 15 0.00074 0.057 14.1 0.8 1 23 387 409 387 409 0.98

5 15 0.0019 0.15 12.8 5.1 1 20 440 459 440 463 0.89

6 15 0.00063 0.049 14.3 1.9 1 23 495 517 495 517 0.95

7 15 0.0091 0.69 10.7 0.4 1 23 523 546 523 546 0.98

8 15 0.028 2.1 9.1 0.4 3 19 555 571 554 572 0.95

9 15 0.00017 0.013 16.1 5.6 1 23 581 603 581 603 0.97

10 15 0.043 3.3 8.5 1.2 2 23 609 630 608 630 0.96

11 15 5.2e-05 0.004 17.7 0.2 1 23 639 661 639 661 0.98

12 15 0.0011 0.084 13.5 0.1 3 23 669 689 667 689 0.97

13 15 5.9e-05 0.0045 17.5 0.5 1 23 695 717 695 718 0.95

14 15 0.054 4.2 8.2 0.4 1 23 728 750 728 750 0.97

15 15 0.00034 0.026 15.1 0.5 1 23 1280 1302 1280 1302 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.9e-05	0.0022	18.5	1.0	1	23	149	171	149	171	0.97
2	15	0.0017	0.13	13.0	1.8	3	23	179	199	177	199	0.94
3	15	9.6e-05	0.0073	16.9	0.1	1	23	359	381	359	381	0.98
4	15	0.00074	0.057	14.1	0.8	1	23	387	409	387	409	0.98
5	15	0.0019	0.15	12.8	5.1	1	20	440	459	440	463	0.89
6	15	0.00063	0.049	14.3	1.9	1	23	495	517	495	517	0.95
7	15	0.0091	0.69	10.7	0.4	1	23	523	546	523	546	0.98
8	15	0.028	2.1	9.1	0.4	3	19	555	571	554	572	0.95
9	15	0.00017	0.013	16.1	5.6	1	23	581	603	581	603	0.97
10	15	0.043	3.3	8.5	1.2	2	23	609	630	608	630	0.96
11	15	5.2e-05	0.004	17.7	0.2	1	23	639	661	639	661	0.98
12	15	0.0011	0.084	13.5	0.1	3	23	669	689	667	689	0.97
13	15	5.9e-05	0.0045	17.5	0.5	1	23	695	717	695	718	0.95
14	15	0.054	4.2	8.2	0.4	1	23	728	750	728	750	0.97
15	15	0.00034	0.026	15.1	0.5	1	23	1280	1302	1280	1302	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCAGTCGACTCCGAATCGGATATCCTGGAAAGCGGCGCTGCCGACAGTGAGGTGACTGCAGCGTATTTGGTGAATGGCAATGCAACCGATGAGGATCTCGACCATATGGCAGCCGAGAATCTCATATTTATGGCGCGAGATGGTCAGCTAAGTGAGATTATAGCTGCCAATGAATCTGGTGGTGGCACAGTCCTAATTACTGACAGTGGCGTTGCATATGCCGAGTCATTCGATGATGAGGCACAGGTGGTCACAGAGGAGATCATTACCGATGATTGGGTGCAGCACCAAGGCGCCGAACGTGTCGAGATCGCTGCTGAGCAAATTGCGGGCAATGCCAATTCGTTGGAGCTACTGGATATGGAGCAGGATGAATATACGGCACTGCGACCCTATCCTTGTGATTTCTGTAGCCGGCGATTTCGTAAAAAGGCCAGTCTCAATAATCACATGTTGGCGCATCAAAACGATCGTCCACATCTGTGTAAATTGTGCGGTGCACGATTTTCACGTCGTAATGAGCTCATTAGTCACTTTAAGGCACATGCCGAAGCTCAGGATGCAGCCGATGCCGAGGCTGCAGCGGCagcttcaattaaatttgagcCACAACAGCAGAGGCAAATGGATGATCATTTCTATGAACAGGAATGGCCATTGTATCAGGAGCAGGAACACGAGCAAATACAGGATCAGGgacaggagcaacaacatttggACCAGGAGCAGTTAACAGTCGCCAGTCAAGTTGTACAACAGGTTAGCTATCCAGCAATAAGCGATGTGCCAGCACCAACAGCTGCCCGGGGGCGTATAAGTCGTCTCAAACCCAAGGAGGAGAGCACACAGTATATTGTGATTGCCGAGAAGCAGACAACTGACGATTTGCAACAGTTTGTAGACTGTGAAGGCTTAGAACCATTGGGTGGCAACGCAACGTCAAGTGATGCCAAATATCCGACAGAGAACGGACAGACCATGGACACATCATCGCGTTTCCCAGTCCTGGATGAGAGCAAACCCTTTGTTTGTCAACAATGTGGTTTGGCATTTGCGCGTGAGAAGGCGCTCGTATCCCATATCAAGAATCATCGCGTGGACTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTTTGGGATAATCAAAGTCTGCAGGAGCATCAAAAGACACATCAGTTCGAGGAGAGCAACTCAGAGTATGATCCTGCTTCGGCGGGGGATGAGAGTGCCAGTGAATCGGAGCCAGAACAGCTTTATGGTGACTTCTACTGCAGTGAATGCGGCATTTCATTTCACAGGCAGGACCTGCTCCGACGCCATTGCAAACAGCAGCACAAGTCCAGCGCTGTGGCATCAACTGTCAACTCTGGTGATGTGGAGGGCAGTGGAGATGCTGATGTCGATGCCGAGAATACCAAAGATGCACCGCATTGTTGTCATACGTGTGGCAAGTCATTTCCCAGCGCATTGGAGCTGCTTGCTCATGCCGAGATTCATGCACGATTTCCGCCATTTAAATGCGTCTTATGTGGTGTAAGCTTTTTCGAGGAACAGGCTATTAAAAGGCATTTGAACACCCGACATCCACATGAGCTCAAGCCAAATTCATGTGTGCTCTGTGGCAAGGAGTGTCGTGATCGCAAGGCGTTAATTAAACACGCCTGGGATCATTCACGTGAAAAATGCCATTCGTGTTCGAAATGTGGCAAGAACTTTCACAACAAGGCGCGTCTGAAGCGACACATGGCCTCGCATCGTGATAAGTCGGTGGTGTGCGAGGTGTGCCACGAGGAATTTCCAGATGGACGCACCCTTTCCAATCATCGTCATTCGCATAGCACAACGTCGCCAGGTAAACTGTTCCCCTGCCTTGAATGTGGCAAGACCTTTGGTTCCCGCAGTTCACAGCAGATTCATGTGCGAATCCACACGGGCGAAAGGCCTTACGGATGTCGATATTGCTGGAAGGCCTTTGCTGATGGAGGCACGTTGCGCAAGCACGAAAGGATTCACACTGGGGAGAAGCCTTATGCCTGCTCTGTTTGTCCTCGTGCGTTTAATCAACGCGTTGTGCTACGGGAGCATATACGATCCCATCATTCGGGATTGGATACAGTGCGTGGCACTTATCATTGCACTGTGTGTACAGCGGATTTATCCTCATCCAATGAACTAATACAGCATCTCATTCAACACAGCGACACGAACACAGCCAAACAACGACAGCCAATTACTGGTCCCCGCAAGTACAAAAGACGGAGGAAACTGCAGCCTCATGAGATTGCACATTTGCGTGCCGAGCTTAAGGATGGGGATGATTATGCCAGCGACATGGATCTCTGCGATCTGGATGTGGAAAATGTGGACGATCTCTTTGATGCAGCAGAACCAACGCCACCCAAGAAGGAAAAGCGAAAGCGCAATGCTGCAAGTCAAGCTAAACCAGAGGCAAATGGCGTTTCAACATCAGCtctaaacaacaaaacaacttcACCATCTAAAGACGCCAATGGGAATCAAGATCGTCTGTGGGAGGAGAAATTCATGCAGGCAAATAGTAATGGCAATGCCAGCAATCAGCTAAATGAGGATGCGTTTAAGAACTTCTTTCAAATTGATTCGCTGGTGGTAGTTAACGATACCACATTGCAACCTGTGAGCTCATCCAGTGGTGCCTCTGCATCCAAGACACGGCGTAGTGGCAAGCACCCGCCACAGACGCAACAGTTGCAGACGAGTAGAAGCAACAAGTCAACGACGGCATCTGCAGGAGATGAATGCAGCAAGTCTAGTGCCTCCGTATCATCCAGCAGTCGCAGCAGCCGTAAGAAAGCTGCCAAGTCAGCCAAAAACTCGGTCTCAACAGCATCCACTTCGAGCAGCTCGCGTCCACGTATGATACACACGGAAAAGTCGCGTGTGCCGCATGAAAATGCGTCGAAGAAAACACGAGGAAGGTCCTACATCACAAGGACAAGCACAAGTGAGAGCAACCAGCTGGGTCTGGTCAAGTCAAGTAGCGTTGCCAGCTCGCGTATTGTAGATGACTATGAGATTATATCACCTGCCACACAGCCGCCGAATCAGATCAGCTCCAGTCCATTGCACATCaagcaggaacaggagcaacagcaacaacgtgtGCCGCTCATGTATGATGACACGCATTTGTTGATCGATGCAGCTCTGTTGCGTGAGAAGACGTACGAGAAGTTCAATCCCAGCATTGTCAATGATCTGGAGGAGATACTGCGTAGTCCGCTCAAGCATGATCGTAATGCGCGTTTACGTTTCACTAGCGAATCATCGACAACGCCACAGTATCTGCCCGAAGAGGAGCAGAATCTTATCAAAATAGAGCCAACGTCACCGGATTTACGTGAAATGGTTGAGAGTCAGCAGCGTGTCAGTTCCACCGGACATACAACAACACcctcctcctcatcatcgtcGGCGGCGCGGACTTCACGCCATCTGCGACAGCTCACTGCCAACTCGAGTTCACGAGCAGCCATGAAAcgtcacagcagcagcaacaaatctGCCTCCAGCTCCAAGAAATCCGCATCATCCTCGTCTGCATCATCTGTTGCCGTAAGCAAAGCCAACTCGTACCTCAGCTATGGCGTGGACTCCTACAATGTGAGTGTTGCCGCCAATGCCAACTCTTCGGATGTAAGCTCAGGATTCTTTTCCATCTCTGAGGTCGTATCCGCTGCAGATGCTGCTGATGCCGCCGCCAAAGCCGCAGCGGCCAATAAACCAGAGCGACGTGCCCGTTCCTATGAGTGTGAAATGTGCTCGTTCAATTTTCCGGATCGAGCTCAGCTGTTGGagcatatgcatatacacatCTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSESDILESGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDSGVAYAESFDDEAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNANSLELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRNELISHFKAHAEAQDAADAEAAAAASIKFEPQQQRQMDDHFYEQEWPLYQEQEHEQIQDQGQEQQHLDQEQLTVASQVVQQVSYPAISDVPAPTAARGRISRLKPKEESTQYIVIAEKQTTDDLQQFVDCEGLEPLGGNATSSDAKYPTENGQTMDTSSRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNQSLQEHQKTHQFEESNSEYDPASAGDESASESEPEQLYGDFYCSECGISFHRQDLLRRHCKQQHKSSAVASTVNSGDVEGSGDADVDAENTKDAPHCCHTCGKSFPSALELLAHAEIHARFPPFKCVLCGVSFFEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCLECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDTVRGTYHCTVCTADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHLRAELKDGDDYASDMDLCDLDVENVDDLFDAAEPTPPKKEKRKRNAASQAKPEANGVSTSALNNKTTSPSKDANGNQDRLWEEKFMQANSNGNASNQLNEDAFKNFFQIDSLVVVNDTTLQPVSSSSGASASKTRRSGKHPPQTQQLQTSRSNKSTTASAGDECSKSSASVSSSSRSSRKKAAKSAKNSVSTASTSSSSRPRMIHTEKSRVPHENASKKTRGRSYITRTSTSESNQLGLVKSSSVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVPLMYDDTHLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQYLPEEEQNLIKIEPTSPDLREMVESQQRVSSTGHTTTPSSSSSSAARTSRHLRQLTANSSSRAAMKRHSSSNKSASSSKKSASSSSASSVAVSKANSYLSYGVDSYNVSVAANANSSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRARSYECEMCSFNFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: iTF_00583846;
80% Identity: -