Basic Information

Gene Symbol
-
Assembly
GCA_005889595.1
Location
MRUE01026719.1:3151-4942[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.11 10 7.1 0.3 1 21 266 286 266 287 0.95
2 10 3.2e-06 0.00031 21.4 1.3 1 23 295 317 295 317 0.99
3 10 0.0009 0.09 13.6 1.1 1 23 320 343 320 343 0.92
4 10 1e-06 0.0001 22.9 0.8 2 23 350 371 349 371 0.98
5 10 1.8e-07 1.8e-05 25.3 0.6 1 23 377 399 377 399 0.98
6 10 1e-05 0.001 19.8 0.6 1 23 405 427 405 427 0.99
7 10 0.00039 0.038 14.8 4.0 1 23 433 455 433 455 0.99
8 10 0.00046 0.046 14.6 0.3 1 23 461 483 461 483 0.98
9 10 9.1e-05 0.0091 16.8 3.7 1 23 489 511 489 511 0.98
10 10 0.00065 0.064 14.1 0.7 1 23 517 539 517 539 0.96

Sequence Information

Coding Sequence
TTTTGGGCATCGCAGCCGCGTCGCGAAGACAATTTGCCAGCCAGAGTCTGTCTCAAGTGTATCAGCGACATCAATCACTGCTACTCCTTTAAGCTCAAGTGCGAGAACTCCAATCGCACGCTGCGCCAGCTGATACCCAATGCGTTGCCCGAGGAGTCTGATGTTGTCGTCGAAGCGAAGCCAGCGGTGATCACAAAAGATGCCACAGCGCAGACAAACGCTGTCACCACCAGCACAAGTGAAGCACAGACTGATGCAGCTGTTGAGGAGCACAACCAAAGCAACGAGAAGCCGACAACGGTGCTCGCCTTTGAACCCGAGGGCGTAGAAGAGTTCGATTACGAATTTTCCGATGAGCAGGATGTGCTGCCGTCGAAGGACAGTGCCGAGAACATCATACTGCATGTGGAAAAGGATAACATAAAATTCGAGACCGAAATGCTCTACAACGAAAGCACCGGTGAGCTGCTCGAGCAGCGTTCCAAAGTGTCCCCCTCCAAGCAAAAAGAGTACAAATATCGCCTGGTTAGCAATGGATCTGGCGACACTTACATTGCTCCAGAACCAGCGCCAACTCTCTCGCAGATGACAACACGCAAGAGCGCATCCaaattgctgcaacaacagcagcagcagcaacaggatcaagaggagcaacagcaggaaaCTCCTTTGGCGTCATCTGCAAAGCGGAGCACACGTCGTCGCACCGCAGCCAAAATGGATGAACAAGCTGATGATGAAGTGAGTCAAGCAAAGCGGCAAGCTACTGAGCTAGAGGATCCCAAAGCCAATTTCCACTGTGATCGCTGCAATGCGGGCTTTGTGTTGGAGAAGTCACTCATCATACACAGACGGCAAAATGGATGCACGAATCGGAGTTTCAAGTGCAACGAATGCGAGCGAGTTTTTGTCTCGTTGAACCATTTAAACGAGCATCAGGCGACGCATGCGGCGCACAATTGCCAGGAGTGCGGCTCACGCTTTGACTCCAGAGAGCAGCTGGGCAGGCACATGGTACAGTCGCACAAGCGCAATCTGCGCAACCAGTGTAACGTGTGCCAGAAGGtcTTTACCATGCTCTCGACATTGCGCGATCACATGCGCATCCACACCGGCGAAAAGCCTTTTGTGTGCAACGTGTGCGGCAAGGGCTTCACCCAGAATGCCAATCTCCGACAGCATAAGCTGCGCCACTCCGACATTAAGCGCTTCAAGTGCGAGCTGTGCAGTAATTCGTTTGTGACCAAGGCAGAGCTCACATCCcacgcgcgcacacacactggcGTCAAGCCGTACGAGTGTGAGGTGTGTTCCTCGAGATTCACCACCAGCTGTTCGCTGGCCAAGCACAAGCGTAAGCATACAGGCGAGCGACCGTATCCCTGTGATCTGTGTCCCATGCGCTTCACCGCACTCAATGTGCTCAAGAATCATCGACGCACCCACACCGGGGAGCGGCCATTTGTGTGTCCATTTTGCTCGAAGAGCTTCACACAGCGTGGCGACTGTCAGATGCATCAGCGGACGCATCAGGGCGACAAAATCTACATTTGTCCCGTGTGCAGCGAGGAATTTAAGTCGATGCACGACATGCGCTCCCACATAACGTTGCACGAGCAGCAGGACAAACGTTTGGCGCACTTTACGCTGTTGAGCAACAAGGAGAATGGCAATGCGGCGACAGAGACACGAGACGAGGACTCCGATGCGGTCGAGGCGGACATGATGTAG
Protein Sequence
FWASQPRREDNLPARVCLKCISDINHCYSFKLKCENSNRTLRQLIPNALPEESDVVVEAKPAVITKDATAQTNAVTTSTSEAQTDAAVEEHNQSNEKPTTVLAFEPEGVEEFDYEFSDEQDVLPSKDSAENIILHVEKDNIKFETEMLYNESTGELLEQRSKVSPSKQKEYKYRLVSNGSGDTYIAPEPAPTLSQMTTRKSASKLLQQQQQQQQDQEEQQQETPLASSAKRSTRRRTAAKMDEQADDEVSQAKRQATELEDPKANFHCDRCNAGFVLEKSLIIHRRQNGCTNRSFKCNECERVFVSLNHLNEHQATHAAHNCQECGSRFDSREQLGRHMVQSHKRNLRNQCNVCQKVFTMLSTLRDHMRIHTGEKPFVCNVCGKGFTQNANLRQHKLRHSDIKRFKCELCSNSFVTKAELTSHARTHTGVKPYECEVCSSRFTTSCSLAKHKRKHTGERPYPCDLCPMRFTALNVLKNHRRTHTGERPFVCPFCSKSFTQRGDCQMHQRTHQGDKIYICPVCSEEFKSMHDMRSHITLHEQQDKRLAHFTLLSNKENGNAATETRDEDSDAVEADMM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00589681;
80% Identity
-