Dmon015786.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila montana
Gene Symbol
lz
Assembly
GCA_003086615.1
Location
LUVX01010997.1:1138-10716[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.8e-18 8.5e-15 54.5 0.0 89 129 74 115 55 115 0.87
2 2 2.3 7.1e+03 -3.4 0.0 68 91 482 506 477 510 0.75

Sequence Information

Coding Sequence
ATGATTTACGCTTTGTTTGTCAACTTAAAAAGCAAACGGCGGCAACAGGCAAAGCCCTTGAAGACATTGcacatacgccgcgttgtcattgacagacaaaacaaaaaaggcaaaacgGCTACGATTCAAGTGCTAGGTGGGGTGCGCATCGTCGTGGGCCTGGCAACACTTGACAATAGCAAAAAGAAGTCAGCCAAGTGGCTGGGACAGTCCTTCTCCAAGTCAGGCTGGTTAGGAAAGAGCTTCACATTAACCATCACAGTGTCAACGAATCCACCACATATAGCTACATATAACAAGGCGATCAAAGTAACCGTCGATGGGCCCCGCGAGCCGCGCTCCAAAACCATGTTATCCCTTttagggcaacaacaacaatttcacttTGCATTTGGCCAGCGACCGTTCCACTTCTCCACGGATCCCCTATCCGGCTTCCGGATGCCGCCAATTGGCAACTGTCAGAGTGCCAGCAACACGCATTGGGGCTACGGATCGGCGGCATCTGCATACTCGCCGTACTTAGCTAGCAGCGGACTATCCTCCTGCACTACGCCCACCTCAGCGCAGTTTAACAATCCAGCGTTGGGCTTCACCTGTTCCTCCAATGACCAAAGCAACAATCAGGACTTTGGGGGCGCCACCAATCGCGACTGTGTGCCAATGCTGCCAGACTCGACAGCCAGCGATTTGGATCAGCATCTCAGTAGTCTGGTCGGATCCTCCAGTGGCCAGATGTCGCATCATAGCTTGTTGGGCGCCAGTGGCCAGACATCCATTACATCGACGGTGAATGGGGCGGGCGCCGGCAGCGGGGCAACCGCTGGAAGTGCAACgggcgctggcggcggcggtggtgccAACTCGATTCTGGTGCCACGATATCATACCAACGCTAGCAATGAGTACAACGTGCATTCCAGCCAGAACGGGCCGCGCAGCCTGAGTGACAGCTCGCAGGCCGAGTCGCCGGTGCAGGAGGATCTGCTGTCCACCAATACACCCAACctgggcagcggcagtggcgcCGGTGCGAGCAATGGCGGCGCCGCCAACGGTGCTGCTagtgctgctggcgctggcagcgGTACCTCAGCAGGTGCATCGGCTGTCGCTGGAAATCCCGCCATGCTGGGCGCCAACCAAAACTTTCCGGGCATTGTTAACCAGGCTCAGCATGCCTCTGCCTCGGCCTATGGCGGCGGCGTTGGTgttggcgtcggcggcggGCATGGCGGCGGTGCTGGGGCCACGGCCGCCGGCTGCAATGGATCGCTCTACCCGGTGCTCCCGGCCAGCCTGCTCTACTCGCAGCTATATACCGCCGCCAATCAGTCGGCGCACGGCTTTCATTCGCACACGCTGCCGGCGCATGCGTCGCCCAACTCCTCCGTGCATGGGGAGCTGCAGAGCGTAATGGATCACATCAGCAATGTCGGCGTACGGCAGCAGCATAACATTATGACTGGCGGGGGCGTGGCGCATCCAGGCGATCTAACATTGATTGGCAACTGCGGCGCGTCGGTGAGGAACATCGAAGATGGAAACACAAATCGTCAGGTGGCCGCGCTCGCTGCCCATCGCGGCCACCATAACCCAACTGACAACGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence
MIYALFVNLKSKRRQQAKPLKTLHIRRVVIDRQNKKGKTATIQVLGGVRIVVGLATLDNSKKKSAKWLGQSFSKSGWLGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSSSGQMSHHSLLGASGQTSITSTVNGAGAGSGATAGSATGAGGGGGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGAGASNGGAANGAASAAGAGSGTSAGASAVAGNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGGGHGGGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01553740;
90% Identity
iTF_00516033; iTF_00559270; iTF_00546432; iTF_00572377; iTF_00582042; iTF_00601540; iTF_00530732; iTF_00512496;
80% Identity
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