Basic Information

Insect: Drosophila monieri
Gene Symbol: ZEB2
Assembly: GCA_035047585.1
Location: JAWNPJ010000087.1:4541761-4543787[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.16 12 6.6 0.2 1 21 322 342 322 343 0.95

2 10 1.1e-06 8.8e-05 22.9 0.3 1 23 351 373 351 373 0.99

3 10 0.00031 0.025 15.1 0.3 1 23 376 399 376 399 0.93

4 10 6.7e-07 5.3e-05 23.5 0.8 2 23 406 427 405 427 0.98

5 10 3.2e-08 2.5e-06 27.7 1.0 1 23 433 455 433 455 0.98

6 10 4.7e-06 0.00037 20.9 0.8 1 23 461 483 461 483 0.99

7 10 0.0011 0.09 13.4 3.1 3 23 491 511 489 511 0.98

8 10 0.00096 0.076 13.6 0.3 1 23 517 539 517 539 0.98

9 10 8.9e-05 0.0071 16.8 3.7 1 23 545 567 545 567 0.99

10 10 0.0027 0.22 12.2 0.1 1 23 573 595 573 595 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.16	12	6.6	0.2	1	21	322	342	322	343	0.95
2	10	1.1e-06	8.8e-05	22.9	0.3	1	23	351	373	351	373	0.99
3	10	0.00031	0.025	15.1	0.3	1	23	376	399	376	399	0.93
4	10	6.7e-07	5.3e-05	23.5	0.8	2	23	406	427	405	427	0.98
5	10	3.2e-08	2.5e-06	27.7	1.0	1	23	433	455	433	455	0.98
6	10	4.7e-06	0.00037	20.9	0.8	1	23	461	483	461	483	0.99
7	10	0.0011	0.09	13.4	3.1	3	23	491	511	489	511	0.98
8	10	0.00096	0.076	13.6	0.3	1	23	517	539	517	539	0.98
9	10	8.9e-05	0.0071	16.8	3.7	1	23	545	567	545	567	0.99
10	10	0.0027	0.22	12.2	0.1	1	23	573	595	573	595	0.96

Sequence Information

Coding Sequence: ATGGATGTTGACAAAATTTGCCTAACCTGCCTCAGCTCTTCGGGTCCTTTGGTGTCCATTTACGATGGGGGATCGGGTAGCTGTCTAGCAGACATGCTGCGTGAATTCACAAAAACAAAGCCTCGGAAGAACGATAACTTGCCGGAGAGGGTGTGCCTGGGTTGCCTGAGCGAGATAAACCACTGCTATACGTTTAAGATTAAGTGCGAAAACTCCAGCCGGACCCTGAGGCAACTGTTACCCAACGCCTTGCCAGAGGAGGCCGACCAGAAGGTGTCTGCTAAAGAGGCAGTTGACACCACGGAACAGGGTGTCCAAACGATAGACTGGGCACCCAAGCAATGCACCTCGTCCGTTCAAACGGACGCAGTGGCCACAGCGGAGGCCGAACAGAATACCAGCCTGGAGAAGCAGGATTTGCCAGACGATCTGGAGGAGGATGAAGGAGAGGTGTTCGACTATGAACTAACTGATGCTCCAGAGGAGAAGACACAGAATATTATCCTTCACTTGCAGGACAGCTTAAAGGATGAGAAGGAAGTGGTGTTTACCCAAACTGATGTAATTTATGAAGGCGACGACAATGAACTGGAGCAGCAGATTCGAGAGTGCAACATGGCCATATTCGAGACGGCTGACGGTGAGGCGGAGATTGTGGAACTGCCCTCTCCCCAGGTAACCACCAGAAATAGCGCGGCTAAGCTTCAaatgcagcagcaaaaacCAGCCAGGGAAACGTCAGAAAGCAAATCAGAAGCTAAAGACGAGGAACAGCCACCGACGGCTAAGAGGACCTCACGTCGTAGACCACCACCTCAGCCGGAGGAGCAAGTAAAgccaccaacagcagcaacagctagTCCAGCAAAACAACTCCGTTTGGGGAGCACCCGGAAATCCCTGAATTCGGTCTCCGTTACCATTCAAGGAGCAACCGCAGCAAGCTTAACCGCCGAACTGAAGTACCATTGCGATCGTTGCAATGCGGGCTTTGCGCTGGAAAAGTCGCTGATCATACACAAGCGCCAGAAGGGCTGCACCAACCGCAACTTCAAGTGTAATGAGTGCGAAAGGGTCTTCGTATCGCCGGAGCACTTAGCCGAGCATCAGGCTACGCATGGAACACATACTTGCGCGGAATGCGGGCTGCAGTTCGAGTCGAAAGAGCAGCTGGGCAAACACATGGTGCAGGGTCACAAGCGAAACCTGCGTAATCAGTGCAACATCTGCCAAAAGGTCTTTACGATGCTTTCAACCTTACGGGACCACATGCGCATCCATACCGGCGAGAAGCCGTTTGTTTGCAATATCTGCGGAAAGAGCTTCACCCAGAACGCCAACTTGAGGCAGCACAAGCTACGCCACTCGGAGACCAAGAGCTTTAAATGTGATCTGTGCCCGCACTCGTTCGTCACCAAGGCGGAGCTGGCTTCTCATGAACGCACCCACACCGGTGATAAGCCCTTTGGGTGCGATGTGTGCCAGGCAAAGTTCACGACCAGTTGCTCTCTGGCCAAGCACAAAAGAAAACACACTGGGGAGCGGCCCTATGCCTGTGACCTTTGTCCTATGCGCTTCACGGCCCTGAATGTGCTCAAGAATCACAGAAGGACGCACACGGGGGAGCGACCGTACGTGTGTCCCTTCTGCTCCAAGACCTTTACGCAACGAGGGGATTGCCAAATGCACCAGCGCACCCATCAGGGCGACCGCATCTACATCTGTCCCGTGTGCAGCGAAGAGTTTAAGTCTATGCCGGATATGCGATCCCATTTGTCGGAACACGAGCAGCATGACAAGCGACTGGTGCATTTCACCCTGCTGAGCAACAAGGAGAATGGCAGTGGAAGTGGTGCTATCGAGGAAGACCTAAACGAAATGGCAGATACGGCGCTAATGCTATAA
Protein Sequence: MDVDKICLTCLSSSGPLVSIYDGGSGSCLADMLREFTKTKPRKNDNLPERVCLGCLSEINHCYTFKIKCENSSRTLRQLLPNALPEEADQKVSAKEAVDTTEQGVQTIDWAPKQCTSSVQTDAVATAEAEQNTSLEKQDLPDDLEEDEGEVFDYELTDAPEEKTQNIILHLQDSLKDEKEVVFTQTDVIYEGDDNELEQQIRECNMAIFETADGEAEIVELPSPQVTTRNSAAKLQMQQQKPARETSESKSEAKDEEQPPTAKRTSRRRPPPQPEEQVKPPTAATASPAKQLRLGSTRKSLNSVSVTIQGATAASLTAELKYHCDRCNAGFALEKSLIIHKRQKGCTNRNFKCNECERVFVSPEHLAEHQATHGTHTCAECGLQFESKEQLGKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCDLCPHSFVTKAELASHERTHTGDKPFGCDVCQAKFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGDRIYICPVCSEEFKSMPDMRSHLSEHEQHDKRLVHFTLLSNKENGSGSGAIEEDLNEMADTALML

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00476066;
90% Identity: iTF_00580112;
80% Identity: -