Basic Information

Insect: Drosophila monieri
Gene Symbol: NFYC
Assembly: GCA_035047585.1
Location: JAWNPJ010000019.1:148739-150771[+]

Transcription Factor Domain

TF Family: NF-YC
Domain: NF-YC domain
PFAM: AnimalTFDB
TF Group: Other Alpha-Helix Group
Description: Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [1]. CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' [2], seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.58 1.1e+04 -4.4 6.8 157 174 64 81 47 129 0.64

2 5 2.5e-45 4.7e-41 141.1 30.4 18 229 132 368 123 376 0.75

3 5 0.0002 3.8 7.0 39.7 139 254 373 496 370 500 0.71

4 5 1 1.9e+04 -25.3 49.6 156 218 500 562 496 585 0.63

5 5 1 1.9e+04 -15.8 28.9 190 222 580 612 563 622 0.59

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.58	1.1e+04	-4.4	6.8	157	174	64	81	47	129	0.64
2	5	2.5e-45	4.7e-41	141.1	30.4	18	229	132	368	123	376	0.75
3	5	0.0002	3.8	7.0	39.7	139	254	373	496	370	500	0.71
4	5	1	1.9e+04	-25.3	49.6	156	218	500	562	496	585	0.63
5	5	1	1.9e+04	-15.8	28.9	190	222	580	612	563	622	0.59

Sequence Information

Coding Sequence: ATGTACGCCACCAACAACGGTGGCACAAACAAGGCGCCAAACAGCAATGCCAGCACGCTGTTCGAGAACACCATAACCGTGACGCCGATAAAGGTGGAGTTGGGCACAACGTATGGCGCCGGAAAGCCCCCAACTCCGGCGCTACAGCGAAGGACGCCCAATGCCGTGGTGGTGACCACTAGCAAtccccaacagcagcagcaacagcagcatcaaACTGGTGCCGGAACCACCACCCTGAACCTGCCCATGCAAGCCACCCTGGTCTCGAATGCCTGCACCATCATGAATCCCAGCCTGAGTGTAACTGTCAATACAACAACCACCGGAGCCCTGGCCAAGGAGCCGAAGGGTAAAGCGGCGCGGGCGCAAGTGGTACGGAAACCGCCGCCCACTATTGacaacttttggccaaatatcGTAAACGAGGTGCATGGAATCGGGCAAGTCGACGCCAAGCATCAAGTCCTGCCACTGGCGCGGATAAAGAAGATAATGAAGCTGGACGAGAACGCCAAGATGATAGCGGGCGAAGCGCCGCTGCTGTTCGCCAAGGCGTGCGAGTACTTCATTCAGGAGCTGACGATGCACGCGTGGGTGCACACCGAGGAGAGTAGGCGGCGCACCCTCCAGCGATCGGACATTGCCCAGGCGATCGCCAATTACGATCAGTTCGACTTCCTTATTGACATTGTGCCGCGCGAGGAGATCAAGCCGTCGTCGGCGCAAAAGAGTAAGGATGCGGGTGGATCGAGTACGTCGAGTGGGAGTGCCACCTCCGGAGTTACCTCATCCACGTCGTCCAGCGCCAGTGCGGGCGGTGTTGTTAGTTCTTCTGTCAATGCGACTGGGGCTACGGTCACGGGATCGGCTGGAGCCGGTGGGAATTTCGTGGTCGGAGCAACTGCTGTACCTGCTGCCAAGATGGATGCGGGTGGTGCGGCCACCGCCACCGAGGTTCTAGGCTTCAGCACGGTTACGCCAGACATGTTCGCCacgcaactgcagcagcagcagcagcagcagcacgtcgtccagcaccagcagcagcaacaacaacagcagcagacgCATCCGCAGCAAGTCCAAATAATCCAGCAGGCGGGGCACGGCGGTGCCCAGCAGTTGCAGTACTTTATTGCGCTGCCGGGCCAGCAGGCGGCACAGCCGGCCCAGAATCATCTGGCCAATAGCCTGGGCCTCAACATCGTGGCCGCCCAACAGCCCGCCCAGCAGCTGATCCTCACTGCGGGTCCCAACGGCCAGCTAACTGCCACCCCAGCACCAGCCGCAACggtgcagcaacagcagacgGCCCTGCTCCAGAATctcgcccagcagcagcagcagcagcaacaacaacaacagcaagcccagcagcaacagcagcagatcCAGCTGCTCCAGCAGGTGGTCACACCCACGGGGGAACTGACCAACGTTCCGATTGCAATCAATGCGAACCACTTGCATCTGCTCCGGCTGCAgatgcagcaacaacagcagcagcaacaacaacaacagcagcagcagcaacaacagcaggtGATCATACCAACGCAACTGCTGACGGCACAGCAGATACTTCAATTGGGCGGAGCACAAGCCGCTGTCGGTCAGCAGCAGGCGCAAGTCCaagtgcaacagcaacagccgcagGTTCAGGTTCAAGTCCAACAGCAGCATCCAAATCTCAGTCAGGGCAGTGCTAGTGGCACAcccatttttataaattcgacAGCGACACAGCAAGtggtgcaacagcaacagcaacagcaacagcaggcgCAGCAACAggcgcaacagcaacaacaacagcagcagcagcaacagagcAACATGGCCGCGGAAAGGACACTAGCTGGGGGCTTCCGGTAA
Protein Sequence: MYATNNGGTNKAPNSNASTLFENTITVTPIKVELGTTYGAGKPPTPALQRRTPNAVVVTTSNPQQQQQQQHQTGAGTTTLNLPMQATLVSNACTIMNPSLSVTVNTTTTGALAKEPKGKAARAQVVRKPPPTIDNFWPNIVNEVHGIGQVDAKHQVLPLARIKKIMKLDENAKMIAGEAPLLFAKACEYFIQELTMHAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSSAQKSKDAGGSSTSSGSATSGVTSSTSSSASAGGVVSSSVNATGATVTGSAGAGGNFVVGATAVPAAKMDAGGAATATEVLGFSTVTPDMFATQLQQQQQQQHVVQHQQQQQQQQQTHPQQVQIIQQAGHGGAQQLQYFIALPGQQAAQPAQNHLANSLGLNIVAAQQPAQQLILTAGPNGQLTATPAPAATVQQQQTALLQNLAQQQQQQQQQQQQAQQQQQQIQLLQQVVTPTGELTNVPIAINANHLHLLRLQMQQQQQQQQQQQQQQQQQQVIIPTQLLTAQQILQLGGAQAAVGQQQAQVQVQQQQPQVQVQVQQQHPNLSQGSASGTPIFINSTATQQVVQQQQQQQQQAQQQAQQQQQQQQQQQSNMAAERTLAGGFR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00545950;
90% Identity: iTF_00481526;
80% Identity: -