Dmim010358.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila mimica
Gene Symbol
NFYC
Assembly
GCA_037043585.1
Location
JBAMBE010000748.1:285823-288546[-]

Transcription Factor Domain

TF Family
NF-YC
Domain
NF-YC domain
PFAM
AnimalTFDB
TF Group
Other Alpha-Helix Group
Description
Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [1]. CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' [2], seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 2.1e-51 1.8e-47 162.1 0.0 18 127 138 247 133 289 0.94
2 4 2 1.7e+04 -11.6 31.1 153 224 365 437 349 441 0.83
3 4 2 1.7e+04 -6.5 63.1 141 266 409 539 401 549 0.62
4 4 2 1.7e+04 -32.9 54.4 151 225 539 618 528 675 0.60

Sequence Information

Coding Sequence
ATGGCCATGTACGCCACCAACAATGGCAGCACAAATAAGGCGCCAAATAGCAATGCAACAACGATGTTTGACAACACAATAACCGTAACGCCAATCAAAATGGAGCTCAGCGATGCTCTGGCCAAGCCAACGGGAGCTGGAGCAACGACGTCGCTGCGTCGGCCAAATGCCGTTATTGTCACCACACAGCAGCTGGCAATGCCCAATGCAATGCACTCGCtgacaaacagcagcaacaacagcaacaacagcggcagcaacactGTCAGTGggagtggcagcagcaattcaAGCGCCATCTATACGGGCATCAGTGTGACGTCCATGTCAACAGTGGCGACGGCTGCAACGGCGCCCAAGGAGAAAGCAACCAAAGCGACTAGAGTTCAAGTGGTGCGTAAACCGCCTCCTACCATTGACAACTTTTGGCCAAACATATTGGGCGAGGTGAACGGGATTGGTCAGGTGGATGCCAAGCATCAGGTATTACCGCTGGCGCGCATCAAGAAGATTATGAAACTGGACGAGAATGCCAAAATGATAGCGGGCGAAGCGCCGCTGCTGTTTGCGAAAGCCTGCGAATATTTTATCCAAGAGTTGACGATGCGCGCCTGGGTCCACACCGAGGAGAGTCGTCGTCGCACGTTGCAGCGTTCGGATATTGCTCAGGCGATTGCCAACTATGATCAATTTGATTTCCTCATCGATATTGTGCCGCGCGAGGAAATCAAACCGTCGACATCAtcaacacaaaaaaccaaagagcCATCCAGCTCAGGTGTGACAACAACATCCTCATCGAATGCTGCTACTCCTGCTaatgctggtgctgctgttggcaacGCTGTTGCTGTGCCGACAGCAACTGCTGTTGTTAGCAATAGCAACCtgaacaacatcagcaacattaGCAATAGCAACCTGAACAACATGTCCAGCGTCAATTTCACAACGAACAATCTATTAGCTGGCGCCAATgtacctgctgctgctgctgctgctgccgccgctgctgcaagTGGCCTCAAGCTGGATGCGGCAACGGCCGAGGTGCTCGGCTTTGGCACCGTCACTCCGGATCTGTTCGCCGCAGCCCAAGTCGCTAGCAATAAtcaccagcagctgcagcagctcaccgcccaacagcaacatcatcagccGCAACAATTGCAGATAATACAGCAGGGAGCCGGTGGCcagcaattgcaatattttattgctcTGCCTAACCAACAACCCACTCAGCTAGTGCAGCAAAtccatcaacatcagcagcaacaacatcagcaacagcagcagctcggaCTGAATATTGTTGCACAGCAGCCGACACAGCAGCTGATCCTCACCGCCGGACCCAATGGCCAGTTGACAGCGACGCCGGCGCCGACAAcagcccaacagcagcaaacggcGCTGCTTCAGAATCTGgcacagcaacatcagcaacaacaacaacaccagcagcagcaacagcaacagcagcaaatccaACTGATCCAGCAGGTTGTCACGCCGAACGGCGAGCTGACCAATGTGCCCATTGCGATAAATGCGaatcagttgcatttgctgcgtctgcagatgcaacagcagcaacagcagcagcagcagcaagttgctGCGGtgcaagcggcagcagcagcagcggcggcagcggcgcaacagcagcagcaacagcagcaggtgaTTATCCCAACGCAATTGTTAACCGCACAGCAGATATTGCAATTAGGCGGCAcgccaacaaatgcaacaactgtgacacagcagcagctgcaactgcaccaacagcaacatcagcagcagcagcatcaacagcagcaacatcatcatcatcagcatatacacataaccaccaatccaaatccaaatggcagcaatgccaacaacactatcagcagcagcagcaacaacagcaacaacggcaacagcagcaacacatcGTCCATATTCATAAATACGGCGTCGAACGCCCAAGTTGCGACgcaggcgcaacaacaacaatcccaGGGTATTGCAACATTAGGCAACGATCGCGGCTTCCGGTAA
Protein Sequence
MAMYATNNGSTNKAPNSNATTMFDNTITVTPIKMELSDALAKPTGAGATTSLRRPNAVIVTTQQLAMPNAMHSLTNSSNNSNNSGSNTVSGSGSSNSSAIYTGISVTSMSTVATAATAPKEKATKATRVQVVRKPPPTIDNFWPNILGEVNGIGQVDAKHQVLPLARIKKIMKLDENAKMIAGEAPLLFAKACEYFIQELTMRAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSTSSTQKTKEPSSSGVTTTSSSNAATPANAGAAVGNAVAVPTATAVVSNSNLNNISNISNSNLNNMSSVNFTTNNLLAGANVPAAAAAAAAAAASGLKLDAATAEVLGFGTVTPDLFAAAQVASNNHQQLQQLTAQQQHHQPQQLQIIQQGAGGQQLQYFIALPNQQPTQLVQQIHQHQQQQHQQQQQLGLNIVAQQPTQQLILTAGPNGQLTATPAPTTAQQQQTALLQNLAQQHQQQQQHQQQQQQQQQIQLIQQVVTPNGELTNVPIAINANQLHLLRLQMQQQQQQQQQQVAAVQAAAAAAAAAAQQQQQQQQVIIPTQLLTAQQILQLGGTPTNATTVTQQQLQLHQQQHQQQQHQQQQHHHHQHIHITTNPNPNGSNANNTISSSSNNSNNGNSSNTSSIFINTASNAQVATQAQQQQSQGIATLGNDRGFR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00501788;
90% Identity
iTF_00557193;
80% Identity
-