Basic Information

Insect: Drosophila mimetica
Gene Symbol: zfh2
Assembly: GCA_037075245.1
Location: JBAMCH010000012.1:1640008-1663191[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.33 25 5.7 0.5 3 23 2 23 1 23 0.96

2 12 0.00011 0.0087 16.6 1.4 2 23 300 322 299 322 0.96

3 12 2.8e-05 0.0021 18.5 0.7 1 23 354 378 354 378 0.92

4 12 0.0049 0.38 11.5 0.4 1 22 475 496 475 499 0.91

5 12 2.7 2.1e+02 2.8 0.4 1 21 642 663 642 664 0.89

6 12 1.1 85 4.1 1.9 1 23 685 709 685 709 0.91

7 12 0.11 8.2 7.3 0.3 1 23 956 979 956 979 0.96

8 12 0.04 3.1 8.6 0.9 2 21 1184 1203 1183 1207 0.89

9 12 5.3e-05 0.0041 17.6 2.3 1 23 1258 1280 1258 1280 0.98

10 12 0.00065 0.05 14.2 1.3 2 23 1287 1309 1286 1309 0.94

11 12 0.00027 0.021 15.4 1.7 1 23 1650 1672 1650 1672 0.97

12 12 0.0079 0.61 10.8 1.8 1 23 1787 1809 1787 1809 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.33	25	5.7	0.5	3	23	2	23	1	23	0.96
2	12	0.00011	0.0087	16.6	1.4	2	23	300	322	299	322	0.96
3	12	2.8e-05	0.0021	18.5	0.7	1	23	354	378	354	378	0.92
4	12	0.0049	0.38	11.5	0.4	1	22	475	496	475	499	0.91
5	12	2.7	2.1e+02	2.8	0.4	1	21	642	663	642	664	0.89
6	12	1.1	85	4.1	1.9	1	23	685	709	685	709	0.91
7	12	0.11	8.2	7.3	0.3	1	23	956	979	956	979	0.96
8	12	0.04	3.1	8.6	0.9	2	21	1184	1203	1183	1207	0.89
9	12	5.3e-05	0.0041	17.6	2.3	1	23	1258	1280	1258	1280	0.98
10	12	0.00065	0.05	14.2	1.3	2	23	1287	1309	1286	1309	0.94
11	12	0.00027	0.021	15.4	1.7	1	23	1650	1672	1650	1672	0.97
12	12	0.0079	0.61	10.8	1.8	1	23	1787	1809	1787	1809	0.96

Sequence Information

Coding Sequence: atgtGTTTCATATGCAAGTTGTCCTTTGGCAACGTGAAGTCCTTTAGTTTGCATGCGAACACTGAACACAGACTCAACCTGGAAGAGCTGGACCAGCAGCTACTTAATCGCGAGTACTCCAGTGCCATTATTCAGCGAAATATGGATGAGAAGCCACAGATATCCTTTCTACAGCCTTTGGATAGTAATGCCACCTGTGCTGCTGGCGATGACACAGAGAAGCTTCAAATAGCCGCTGAGGGCGGTGGCCCCATTCTTCCGTCGTCTCCGCAGCCTGTTCTCGGCAATGAGGGCGAACTGGAGCTCGAGATCCAGCCGGCGGATGAGCTGGTCCGGGTCCTGGACCAGGGCCGGGAGCAggagcgggagcaggagcCTGAAACCGACCAGGATTCTACGCTGGCCGCCAATGAGTCGAATGAAAACCGGGTTAAGTTGATCACAGAGTTCCTCCAACAGCAGCtacagcagcatcagcagcaaagTTCCTTATTTCCCAGCCAATGTCCCGAGCACCCGGACTTGAATGGTGTGGATTGCAAAGCCTGCGAGCTCCACGACATCCAGCAGCGGTCAAAGTCGCCGCCCTCCTCGCATCAGCATCTCTCCCAATCCCTGCCCCAGCTTCAGGTtcagccgcagccgcagcccCAGCAGATCCCACATCGTTCTCCGTGCAGCAACAGCGTTGGCCTGGCCATATCACCCAGTGCCTCCTCGGTGGCCAGCGTTGGGAATGCGTCGAGCGCCACTACCAGCTTCACAATCGGCGCCTGTTCTGAGCACATCAATGGTCGTCCCCAAGGAGTGGACTGTGCGCGCTGTGAAATGCTTCTAAACTCGGCTCGCTTAAACAGCGGCGTGCAAATGTCTACTCGCAACTCCTGCAAGACTCTAAAGTGTCCGCAATGCAATTGGCACTATAAATACCAGGAGACACTGGAGATCCACATGCGGGAAAAGCATCCTGATGGGGAGAGTGCCTGTGGTTACTGCCTTGCAGGGCAACAGCATCCTCGGCTGGCACGGGGGGAATCCTACTCCTGCGGTTATAAGCCGTATCGCTGTGAAATCTGTAACTACTCCACGACCACCAAGGGTAACCTCTCCATTCATATGCAATCGGACAAGCACCTGAACAACATGCAGGAGTTAAACAGCTCCCAGAATATGGTggcggctgcggctgctgcagcagcgacTAGCAAGCTGCTGCTCTCGAGCACGTCGCCCCAAGGTTCTGGTGCGGGTACGTCCAGCAGTGGATCCAGCGGCGCCACTGGCTCCTCCGCCTGCGGAGGATCCAACAATGTCGGCGTCAACCCACCACTGGGTGGAAACGCACCGATCGCAGGTACGGGATCAAGTAACTCCAGTGGCAGTACCGGAAGCAGCGCCAACAGCGCCAAGCCCAAGCCCTCGTTTCGGTGCGACATCTGCAGCTATGAGACTTCCGTGGCCCGCAACCTGCGCATCCACATGACCAGTGAGAAGCATACACACAACATGGCTGTGCTGCAGAACAACATCAAGCACATCCAGGCGTTTAACTTcttgcagcaacagcagcagcaacaaggaGCTGCTGGCAGTGTTCCAGGACACAGCCCTGGGGGTTTTATGCCCGAGGTTGCGTTGGCCGATCTCGCGTATAACCAGGCGCTTATGATCCAGCTGCtacaccaacagcaacagcaacagcatcagcaGTCGGCTAATAGCAAATTATCACCCTCGTCCTCGCCTGTGAGCACTCCGGATCAGTTTTCGTTCTCTCCCAAGCCAATGAAGATTAGTCACGGAGCAGGAGTAGGCATGGCCATAGGGATGCCAATGGGAATGAGCCTCTCGAACGAGGTACCCGGCGACCTGGCTGGTGATCCGCATCCGCTGACGAAAACTGATAGGTGGCCCACGGCGTTCTATAGCTGTCTGATCTGCGACTGCTTCAGTACGAACAACTTGGACGATCTGAATCAGCACTTGCTCGTAGATCGATCTAGGCAGTCCTCCAGCGCCTCTTCCGAAATAATGGTTATCCACAATAACAACTATATATGCCGACTGTGCAATTACAAGACGAATCTCAAGGCCAATTTCCAACTGCACAGCAAGACAGACAAGCACTTGCAGAAGCTCAACTTCATCAACCACATCAGGGAGGGCGGACCCCGTAATGAGTACAAGATGCAGTATCAGCAACAGCTGGCCGCAAATGTAGTACAAGTAAAGTGCAACTGCTGCGACTTCCACACAAATTCTATTCAGAAGCTGTCCCTGCACACACAGCAAATGCGCCACGACACGATGCGAATGGTATTCCAGCACCTACTCTATATTGTTCAGCAGAGTCAAATGAACAAGAATTCCCAAGGTACTTCGGAGGATGATCCGCAGTGCTCCTGTCCGGATGAGGATCAGCAaacgcagtcgcagtcgcagtccgCCAAGAAACTGCTCCTCTGCCAGCTGTGCAACTTTACTGCCAAGAACCTGCACGAAATGGTTCAGCATGTAAAGGGCATGAGGCACATGCAGGTCGAGCAATTTATTTGCTTGCAGCGTCGAAGTGAAAACCAGGAAATACCCGCACTATGCGACGTGTTTAGAGTGACAGAGGAGATTATGGACACCGAAGATATTACTTTCGAACCTGGATTTAACCTATCAAGAACAGCACCCAGCGAAGCCACCCCGGATGCCAACTATGCCGCGGCATCATCTGCGTCTGGAGTCTCAGCCATTCCCGATGCCAGTATATTCTCACCGACATCTCCCTCCACACCTTGCAGCAAGACTGTGGGTCACATTGCATCTCCGGGCGTAAATAACTTTGGTCCGGGGGCCCCTGTTCCTACCACAGTATTCAAGTGCAATCTCTGCGAGTACTTCGTGCAATCGAAAAGCGACATTGCGTCTCATATTGAGTCTGAGCACCCGTGCGCCGAGAGTGATGACTTTATAAGTATTCCGACCAACACGGCCGCTCTGCAGGCTTTCCAAACAGCTGTGGCAGCAGCTGCTCTGGCTGCGGTACAGCAGCGGTGCGCCGCTATTAATGCTCCGACACAGAATGCAGTTGACACAGACAAGGACCTGGATGCGAGTGCCAGTGACGGCCCTGTGGCTATTAAGAGGGAGCGGCTTGAGGACGATGATGATCCCATGGCAGTTACAGAAGATACCAAAGAGGTTGCAGCCCAGGCGGCGTCCTCTGCAGCTCCGGAGTCGCCGAAAGATCCGGAAAACCAAGTGGGGGTCCAGTGTCCGCTGTGCCTGGAAAATCACTTCCGGGAAAAGCAATACCTGGAGGCGCACTTGACAAGCGTCCACAGCGTTACAAGAGATGGTCTTTCCCGGCTCTTGCTGTTAGTCGATCAGAAAGCCTGGAAAAACGAGAGTGAGGGCACTGATCCTCCAAGCCTGCCCGCCCAACCAAACAACAATAAGGAAGAGGCCACACCAACATCTAGTGAGTGCCCCTCCGGTGCCAACGCATCCAAGTGCTCCGCATCTAACCCCAGCCTTCCAGTGGGAATGCAGGGCCTCTCCTGCCAGCAGTGCGAGGCCAGCTTCAAGCACGAGGAACAGCTGCTCCAGCATGCGCAACAGAACCAGCACTTTCCGTCGCAAAACGGGGAGTATTTGTGTCTTGCAGCCAGCCACATCAGCCGTCCCTGCTACATGGGCTTTAGGACCATTTCAGCTATGATCAGCCACTTCCAGGAGTCACACATGAGCCTTGTTATCTCGGAGCGACATGTCTACAAGTATCGCTGCAAACAGTGCTCGCTGGCGTTCAAAACTCAAGAAAAGCTTACCACGCACATGCTCTACCACACGATGCGGGATGCCACAAAGTGCTCTCTTTGCCAGCGCAACTTTCGCAGCACCCAGGCGCTGCAAAAGCACATGGAGCAGGCCCACGCAGAAGAGGGAGGCCCATTGCGCAGGTCAAACAGCCCACAAACACCGACTCCGAATGCCGAGGAGGCACACAAGCATTCTCCAGGGGAGACATTTGGGGGGGAGAGAGAAGTCACAGGGAACGATGTGTCGCCGCTTCGGCTGGAGGCGCAACAAAGAAAGGACTCTGGGCACTTGTCTCCTAGCCCAGTGTCTGCGGATTCCCAGGCCCAGCAGCAATATCTCGCTACTTTCGCAGCTCTGCTCAAGCAGCAACAGGGTAGCTCAGATGCTGTTGGCCTCCACAACGAAGCCTTGTCGCTGTCTGCTGGAGAATTCTCCCAGCACTTACAGGGTCTTCAAAATCTGCAAAACCTTCAGCATATGCAACACCAATTTGGGGCCGTAGCTGCCGCATCCGGACTACCAATAAATCCGGTGGATATGCTAAATCTGATGCAGTTTCACCACTTGATGTCCCTGAATTTTATGAACCTGGCTCCTCCCTTGGTATTCGGCGCTGGCTCCGCCGGTAGCAATGCTGTTACCGCGCCATCAGCACAAAGTAACAGCATTACCTCCTCCACCGTAGCAGCTGCTTCAGGACTAGCTGATGTTCCGCTTACTGCGGGAGTTACCGCTCTTCCGGTTGACTCTGCTAAAGCTATTGCTTCAGCTCAGCCTCAGCACAATGTCAACTCAAACTCTCAGCTGGCCAGCAACCAAAAACGAGCACGAACGCGAATCACGGATGATCAGTTAAAGATTTTACGGGCACATTTCGACATAAATAACTCGCCAAGCGAAGAGAGCATTATGGAAATGTCACAGAAAGCAAATCTACCAATGAAGGTGGTTAAGCACTGGTTCCGAAACACCTTGTTTAAGGAAAGACAACGCAATAAGGACTCtccttataattttaataatccaCCGTCGACAACACTTAATTTGGAAGAACAAAAGCAACGCAAGATTTACGAGAACCAACCGAACAACTCCCTGTTTGAAAACGAGGAGACCAAAAAACAGAACATTAACTATGCGTGCAAGAAGTGCAGCTTGGTCTTCCAGAGGTACTATGAGCTAATACGTCACCAGAAAAACCACTGTTTCAAGGAGGAGAATAACAAGAAGTCGGCTAAGGCACAAATAGCTGCTGCTCAAATAGCACAGAACTTAAGCTCAGAGGACTCAAACTCCTCTATGGATATACACCATGTCGGCATTTGTCCACCAGGCCCCACCGCAGTTGGGCAATCTTTGTCATCAGTTGCTTCTGCCGCTCCTTTGCCGGGACAGTACGTACAACAATCATTTGGAGCATTGCCCTCACCACAGCACTTATTCGCAAAGTCTTCTTCGCTCACTGACTTCAGCCCCTCCACGACCCCCACACCACCCCAGCGGGAACGCAGCAACAGTTTGGACCATCCACAACGACCTCCCAAGTTTGACTGTGATAAGTGCGAGCTGCAGTTTAACCACTTGGACAAATTGCGAGAGCATCAACTATTACACCTCATGAATCCAACTAACATATTTTCTGACGATGGCCAGAACTCGAGTCCTGATGCCAATTTCGAGATATCTAAGAAAGTTAATCTGAAGAAACGCGTTGTGCAAGTTTGGTTTCAAAATTCTCGGGCCAAAGATAAGAAATCCCGCAATCAGCGACATTATGCGCACATATCTGACGATAACAGCTATGATGGCTCTAATGGCAAGGAAGTGGTCAGCGACCTAAAAGCTAATGGCGTATCCGTTGAACAGGATCACGAACCAAATCTACAGGACTGCCAGCTGTGCCAAGTCACCCAAGTCAACATCCAAAAGCACGCTTTTAGCGTTGAGCATATCTGCAAGATGAAGAAGTTACTCGAAAAAACCACCGAGCTTTATGCCCAGAGcaatggcagcggcagcgatgATAACGATTCCGACCGGGAAAAGCGATTTTACAACTTATCAAAGGCCTTTCTATTCCAGCACCATACTTTGCCTGCCGATGTTGTCTCTGAAGATGTGCGAAAAATCGCTGGTAATCAGGAACTTATGCAGCAGCTATTTAACCGAAACCATATCACCGttataGGTGGAAAGTGA
Protein Sequence: MCFICKLSFGNVKSFSLHANTEHRLNLEELDQQLLNREYSSAIIQRNMDEKPQISFLQPLDSNATCAAGDDTEKLQIAAEGGGPILPSSPQPVLGNEGELELEIQPADELVRVLDQGREQEREQEPETDQDSTLAANESNENRVKLITEFLQQQLQQHQQQSSLFPSQCPEHPDLNGVDCKACELHDIQQRSKSPPSSHQHLSQSLPQLQVQPQPQPQQIPHRSPCSNSVGLAISPSASSVASVGNASSATTSFTIGACSEHINGRPQGVDCARCEMLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAATSKLLLSSTSPQGSGAGTSSSGSSGATGSSACGGSNNVGVNPPLGGNAPIAGTGSSNSSGSTGSSANSAKPKPSFRCDICSYETSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNFLQQQQQQQGAAGSVPGHSPGGFMPEVALADLAYNQALMIQLLHQQQQQQHQQSANSKLSPSSSPVSTPDQFSFSPKPMKISHGAGVGMAIGMPMGMSLSNEVPGDLAGDPHPLTKTDRWPTAFYSCLICDCFSTNNLDDLNQHLLVDRSRQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGPRNEYKMQYQQQLAANVVQVKCNCCDFHTNSIQKLSLHTQQMRHDTMRMVFQHLLYIVQQSQMNKNSQGTSEDDPQCSCPDEDQQTQSQSQSAKKLLLCQLCNFTAKNLHEMVQHVKGMRHMQVEQFICLQRRSENQEIPALCDVFRVTEEIMDTEDITFEPGFNLSRTAPSEATPDANYAAASSASGVSAIPDASIFSPTSPSTPCSKTVGHIASPGVNNFGPGAPVPTTVFKCNLCEYFVQSKSDIASHIESEHPCAESDDFISIPTNTAALQAFQTAVAAAALAAVQQRCAAINAPTQNAVDTDKDLDASASDGPVAIKRERLEDDDDPMAVTEDTKEVAAQAASSAAPESPKDPENQVGVQCPLCLENHFREKQYLEAHLTSVHSVTRDGLSRLLLLVDQKAWKNESEGTDPPSLPAQPNNNKEEATPTSSECPSGANASKCSASNPSLPVGMQGLSCQQCEASFKHEEQLLQHAQQNQHFPSQNGEYLCLAASHISRPCYMGFRTISAMISHFQESHMSLVISERHVYKYRCKQCSLAFKTQEKLTTHMLYHTMRDATKCSLCQRNFRSTQALQKHMEQAHAEEGGPLRRSNSPQTPTPNAEEAHKHSPGETFGGEREVTGNDVSPLRLEAQQRKDSGHLSPSPVSADSQAQQQYLATFAALLKQQQGSSDAVGLHNEALSLSAGEFSQHLQGLQNLQNLQHMQHQFGAVAAASGLPINPVDMLNLMQFHHLMSLNFMNLAPPLVFGAGSAGSNAVTAPSAQSNSITSSTVAAASGLADVPLTAGVTALPVDSAKAIASAQPQHNVNSNSQLASNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEQKQRKIYENQPNNSLFENEETKKQNINYACKKCSLVFQRYYELIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGPTAVGQSLSSVASAAPLPGQYVQQSFGALPSPQHLFAKSSSLTDFSPSTTPTPPQRERSNSLDHPQRPPKFDCDKCELQFNHLDKLREHQLLHLMNPTNIFSDDGQNSSPDANFEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYAHISDDNSYDGSNGKEVVSDLKANGVSVEQDHEPNLQDCQLCQVTQVNIQKHAFSVEHICKMKKLLEKTTELYAQSNGSGSDDNDSDREKRFYNLSKAFLFQHHTLPADVVSEDVRKIAGNQELMQQLFNRNHITVIGGK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00581862;
90% Identity: iTF_00547913;
80% Identity: iTF_00547913;