Dmet014359.1
Basic Information
- Insect
- Drosophila mettleri
- Gene Symbol
- -
- Assembly
- GCA_035047625.1
- Location
- JAWNPI010000109.1:7921967-7924824[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 12 0.012 0.83 10.2 0.9 2 23 143 165 142 165 0.92 2 12 3.7e-06 0.00025 21.3 1.7 2 23 179 201 178 201 0.96 3 12 0.35 24 5.6 8.8 2 23 457 478 457 478 0.97 4 12 1.2e-06 7.9e-05 22.9 2.8 1 23 484 507 484 507 0.96 5 12 0.002 0.14 12.7 0.4 1 23 512 535 512 535 0.96 6 12 0.00014 0.0096 16.3 4.6 1 23 553 575 553 575 0.96 7 12 0.00012 0.0082 16.5 1.6 1 23 580 602 580 602 0.98 8 12 3.2e-05 0.0021 18.3 1.7 1 23 608 630 608 630 0.95 9 12 0.00031 0.021 15.2 0.7 1 23 636 658 636 658 0.98 10 12 3.3e-07 2.2e-05 24.6 2.7 3 23 666 686 665 686 0.99 11 12 2.2e-08 1.5e-06 28.3 1.0 1 23 692 714 692 714 0.99 12 12 1.3 88 3.8 5.6 1 23 719 742 719 742 0.89
Sequence Information
- Coding Sequence
- ATGCCTGACACCTGCGGCCAGTTCGATGCGGAGCGCGTCTGCCGTGTTTGCCTGCGTGAAGTGGGCGATTTCTACTTCATCTACGATGAGGCGCCTGTGGAGCAGGGCGCGAACATAGCCCAAATACTTAACGAATGCACGCGCTACACCTGCGAGCGATATGACAAGATGCCCCATCATATGTGCGACACCTGCATCAAGGCCGCCTGCCAAGCGTATCGCTTCAAACAGGACGCAGAGAAGGCCTATCGCTCGCTAGTGGCTATGCTGGGCCGCACACCTGTGACGAAGCCCAACAGTAACGATGTGTGCACCCAGACTGAGCAATTGCCCATGCTGCCCTGCGGTATCTGTAATGATAAATTTCTTAACATTCTCGAACTGCGTCTGCATCGCAGTCGTCAGCATTTAAATGCGGAGCAGCTGAAGTGCAAGCTCTGCGACGAGCAGTTCCAAAAGGTGCGGCAGCTGCGCAACCATCTAGCCGAGAAGCATGATCAAAAGTCAGCGACGCCGTTGTTACGTCGACGTCTGGAATGTCGAGTATGTCAACGCGCGTTCACGCGACGAGATCATCTTCTACGCCATATGCAGAGCGTCCATGATGAGCCTCGGCAGCCGGAGCCGGAGTCTGAAGCGACTTGGACGCCGAATGATGAGTCAACTATGCAAAGCGGTGATGAACTCGAATCGGCGGCTGTCCTATTCAATGATCCGGCTGCCTGTTCCGACAACGAGCATAACGAGAGTGGCTATCAATGCCATACGACTAACCCCATATCGAGCAATGAGGATTCTGCCGACGATGATGTACGTGCCGAGGCTAAAGAATCACTCTGGCTGCACATTAAGCCAGAGCCCGAACCCGAACTGGACACGGAACTCGAGCAGGTGGATCGCGACAGGcgcaaaaagaaatcaaattcaaaagtCGCAgttcacacagacacagaggaGGAGAGTGAAGGCATTGGGAAGCAGAAGCCCGCTGTTACAAGTTCATACTCAACAGAGGTGAAAGAGGAGCCACTCACTGCCGGCAGTGAGCAGCAAATGGCCATTAAAGAGGAGCGGCAGCGGGCGGACAGCATCAAAGTGGATGAGGAGTATCAGGTGGAGGTCGCAACAGCTGATCTCTTTCATAGCGCTGACGAGGATGAAGATATCGTAGATGAGGAGAGTGACATTGATGACGAGGACGACGAAGATGACGATGAGGATGAAGCCAGTGCGGGGCTCGATGAGCACAAGTCGAAGCTAGCGCAAGTGGAAATCGTGCGGGAGTATTTGCAAAAGCCGGCAACTGGCaagcagcgacgtcgacgacgCAAAAAGACGCAAAGCGAAACGGAAGCAAATCCCGAAAATCGCTGCGATGTCTGCATGCGCACCTTCTCCCGCCATTGCCATTTGTTGCGGCACAAATTGTCGCATTTGGAGAAGAAGCCGCACAGCTGTCCGCATTGCCCCAAGGCCTTTGCGCGCAGCGATCACCTGAAGGCGCACGTGCAGAGTCTGCACGGCAATAAGGAGCACAAGTGTGTGCTCTGCGATGCGGCGTTCGCCCGTCTCGACGCCCTCGATCGGCACAAGATGAGCAAACACAACGGCGAGGGCCTCGATGCCAGCAACGAGCTCAAGCTGCAGATGAGCGAGCATACGTGCGAGTACTGTGCGAAGCGTTTCTCCAGCAAGACATACCTGCGCAAGCACACGCTACTGCACACCGAGTTCCTATACGCCTGCAAGAGCTGTGACGAGACGTTCAAGGAGCGCCAACAGCTGCGCAGCCACGAGAAGACCCACACGGGCCAGCGTAATTTCCTCTGTTGCATTTGCGGCGACAGTTTCGCGCGCAACGATTATCTGCGCGTCCATATGCGGCGGCACAACGGTGAGAAGCCATACAAGTGCCGTTACTGCATCAAAGCATTTCCACGCGCAACCGATCTCAAGGTACACGAGCGATATCACACGGGCACCAAGCCCAATCTGTGCAACACCTGCGGCAAGAGCTTCCATCGCGCCTACAATCTGACCATACACATGCGCACCCATACGGGCGAACGTCCGTACAAGTGTGATCAGTGCCCGAAGAGCTTTAGCCAGAGCAACGACTTGAAGGCCCACATACGACGGCATACGGGCGAGCGATACAAGTGCCCGCATTGCGACGCCTACTTTCTGCAGCTGTATCACATGCGCAACCATTGCCTGACCGCCCACAATAAGCACATTGAGACGAAGACGGGTCGGCTGCAGCGCACCGGCTTGCTGGACGAGCCCAATCAGTCGCATCTGACCACTGTCGTAATGCCGCCTGCACGTTATCAACAAACGACGCCCGATCCGCATCCGTCGGCCACTGTCACCACGCAGTTGCCAACGACAACGATTGCGACGCCCATAATGCATTCACCGGTGACCTATAGCACAACGTCAccggcaccagcaccagcaccagcagcagtgtccgtgtccgtgccACTGTCCGATGCAGGCGGCTTCGTGGCTGCAACGACAAATGCAACGAGCACAACGGCGACGGCACCATTTGGCACCTTCAGCATTGCGCCCGTGGTGATGgCGCATCTGATGTACAATCACGGCGGCAACAGCCAGCAGAGCAATGCGAGCAAATAA
- Protein Sequence
- MPDTCGQFDAERVCRVCLREVGDFYFIYDEAPVEQGANIAQILNECTRYTCERYDKMPHHMCDTCIKAACQAYRFKQDAEKAYRSLVAMLGRTPVTKPNSNDVCTQTEQLPMLPCGICNDKFLNILELRLHRSRQHLNAEQLKCKLCDEQFQKVRQLRNHLAEKHDQKSATPLLRRRLECRVCQRAFTRRDHLLRHMQSVHDEPRQPEPESEATWTPNDESTMQSGDELESAAVLFNDPAACSDNEHNESGYQCHTTNPISSNEDSADDDVRAEAKESLWLHIKPEPEPELDTELEQVDRDRRKKKSNSKVAVHTDTEEESEGIGKQKPAVTSSYSTEVKEEPLTAGSEQQMAIKEERQRADSIKVDEEYQVEVATADLFHSADEDEDIVDEESDIDDEDDEDDDEDEASAGLDEHKSKLAQVEIVREYLQKPATGKQRRRRRKKTQSETEANPENRCDVCMRTFSRHCHLLRHKLSHLEKKPHSCPHCPKAFARSDHLKAHVQSLHGNKEHKCVLCDAAFARLDALDRHKMSKHNGEGLDASNELKLQMSEHTCEYCAKRFSSKTYLRKHTLLHTEFLYACKSCDETFKERQQLRSHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRYCIKAFPRATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFSQSNDLKAHIRRHTGERYKCPHCDAYFLQLYHMRNHCLTAHNKHIETKTGRLQRTGLLDEPNQSHLTTVVMPPARYQQTTPDPHPSATVTTQLPTTTIATPIMHSPVTYSTTSPAPAPAPAAVSVSVPLSDAGGFVAATTNATSTTATAPFGTFSIAPVVMAHLMYNHGGNSQQSNASK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00532523;
- 90% Identity
- iTF_00544635;
- 80% Identity
- -