Dmet005608.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila mettleri
Gene Symbol
su(Hw)
Assembly
GCA_035047625.1
Location
JAWNPI010000056.1:6811677-6814765[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00063 0.043 14.2 2.2 1 20 221 240 221 242 0.94
2 12 2.6e-06 0.00018 21.7 0.4 3 23 293 314 291 314 0.93
3 12 0.009 0.61 10.6 0.1 1 23 320 342 320 342 0.97
4 12 7.1e-07 4.9e-05 23.5 2.5 1 21 349 369 349 370 0.95
5 12 3.1e-06 0.00021 21.5 0.6 2 23 382 403 381 403 0.96
6 12 9.9e-05 0.0067 16.8 5.3 1 23 414 436 414 436 0.99
7 12 7.7e-05 0.0052 17.1 0.9 1 23 442 464 442 464 0.97
8 12 1.5e-05 0.001 19.3 0.8 1 23 470 492 470 492 0.99
9 12 1.4e-06 9.6e-05 22.6 3.0 1 23 498 520 498 520 0.98
10 12 0.0031 0.21 12.1 1.4 1 23 524 546 524 546 0.97
11 12 3.5e-05 0.0024 18.2 0.2 1 21 554 574 554 578 0.92
12 12 8.5e-05 0.0058 17.0 0.3 3 23 598 619 596 619 0.96

Sequence Information

Coding Sequence
ATGAGCGCCAGCAAGGAAGCCGCTGCGCCAGCCCCGGCCAGCAACAAAGAGACCAGCACACCCGTCATCAGAGTAATGGACATGGACAAAATGGTTTCCCCGAAGACAAAGCGCACTGGCACCCGAATGAAGCTGCTCAATGACGTGGCTGCGCGCCCCAAACAGGAGAAGCGCACCAGCATCAAGATACTCAACAACGATGACGCCCAGAGCAGCTCGTCAAAAGGCGGCGACAAGCGTGCCACGCCCAAAACGGTGAGCCCCGGCGTCAAGATATTAAACGAGAAGCGAATCGTGCCCGCTGCCACAGCCATGGAAACGGCCAAGATAAAGACATCGcccagcaagaagaagaaaatggaTCACTATGTGCTGCAGGCCATCAAGAGTGAGAACAGCAAGGCGGACAACACGACGGGCGTTGTGGTAGTCGACGACGAAGACACCATTGACTTCATACTGGCCGACGATGATGTGGAGCTAGGAGATGCTTCCAAGGAGAATGGCGACGAGTTTGTGGTGTCTGGCATCgaggatgatgatgacgatgaagaCGAGGATGATGAAGACGACGAGGATGGGCCAGCCGGTGGAGCGAACGGGGCAAAGCGCAAgagtggcaacagcagcaataacaacgaGCTCAAGGAGATGGTCGAGCACGTGTGCGGCAAGTGCTACAAGACATTCCGTCGCGTCAAGAGTCTGAAGAAGCATTTGGAGTTCTGTCGCTACGACAGCGGCTATCATCTGCGCAAGGCGGACATGCTGAAAAATCTGGACAAGATTGAGCGCGATGCCGTCGTCATGGAGAAGAAGGACATTTGTTTCTGTTGCAGCGAGAGCTACGATACCTTTCATCTGGGCCACATCAACTGCCCCGATTGTCCCAAGTCGTTCAAAACACAGACGAGCTACGAGCGTCACATTTTCATCACACACTCGGAGTTCAACGATTATCCATGCTCCATTTGCAATGCGAAGCTGCGCAGCGCGGCGCTGCTAAAACTGcacgagcagcagcatcagtccAGGGGCAAGCCGTTTGCCTGCAAGATCTGCGGTAAGGACTTCACCCGATCATATCATCTGAAGCGTCATCAGAAGTATTCGTCGTGCTCCGCCAACGAGAACGATACCATGAGCTGCAAGGTGTGCGATCGCGTCTTCTATCGCTTAGACAATTTGCGCGCCCACCTCAAGCAGCACCTGGGTACCCAGGTGGTGAAGAAGCCGGAGTACATGTGCCACGTGTGCAAGAACTGCTTCTACAGTCTGTCCACGCTCAACATTCATATACGCACTCATACGGGCGAGAAGCCATTCGATTGTGATTTGTGCGACAAGAAGTTTTCGGCTTTGGTAGCCCTCAAGAAGCATCGTCGCTATCATACGGGCGAGAAGCCCTACACCTGCACAGTGTGCAGTCAGTCGTTTGCCGTGAAGGAGGTGCTTAATCGCCACATGAAGCGGCACACGGGCGAGCGGCCGCACAAGTGCAACGAGTGTGGGAAGAGCTTCATTCAGGCCACTCAGCTGCGCACGCATTCCAAGACGCATCTGCGTCCCTACTCCTGCTCCTTGTGCATTCAAAAGTTCAAGACGGAGAAACAACTCGAGCGCCATGTCAAGGAGCACTCGCGCCAGAAACGCGCCTCGTTTGCCTGCTCGGAGTGCACACGAAGCTTCCGCACCAGCGCACTGCTGAAGGAGCACATGGACGCTGGCGACCATTCGCCTATTAAGCCGACGCGCGCTAAGCGTACGGCCAAGGTGATCGAGCGCACGGATTGCGCAATTTGCGACAAGAACTTCGACAGCACTGAGACGCTCCGCAATCACATACGCAACGTGCACGAGTGCGATCCGGATGACATTTTTGGCACAGAGCCGCCAGCCAAGCGCAAGGCTAACAAGAAGTCCGCCGTGGTGCTAGAGGAGGAGGaagacgaggaggaggaggaggaggcaaATGAAGATAAAGACCAGGATAAGGATACAGCGACTGCCAATACATCAGCTGGTTCGCTTATCTCCAGCAAAACGGATGGCAACGGAGTGGTGGTGCGCGAGTTTTTGGTGGATGAGAGCGACGGCAATGCCCAGACCATTGTGCTCGAGAACGAGGTGTACACCATTTTGCCTCTGGAGGGTGCGGGTGCAGGTGCAGCCAGCACAGCCGAGCCGACGAAGGAGATCGGCGAGGCCAAGGCCGATTCGAAGGAGAAGCCACAGTCGGCCGTGTCGCCGGTGGTCAAGAGGGAGCAGCGTAAATCGCTGGCCGCCAGCTTGGCCGCCGCCATTGCGGACAATCTGGATGAGCCCTCAAGCGATGATGAGTTCAACGGCGAGGCGCTCTCCGAGGAGGATATTAAGCTGAAGGAGAACATAGCGAAGCTAATCGATATGCTGGTTGATCCGCAAACACTCAAGAAATATAACTGGCCGCACAGCTCCGAGGAGTCGGTGCTATGCAAGGTCATCGAGAACTGTGGCCACGACCTGGCCAAGGGCAGCGAGGCCTACGCCGAGTTGGACTACGGCAGTCGCATGCGTGAATACTGCAAGCTCCTGTTCACGGTGGTCATACACAATGATTCCATCAAGGCGCTGCTCAACAACTTTCCCATCGACGATGTCATTGAGTATGTTCTGGGCGATGAAGACCAGGACCAGGATCAGGAGGCGGACAAGGGCAAGGAGAAGGAGAACGATGCCGACAAATCGGATGCGGAGACCAGACAAGATGAAGCTGACGCTTAG
Protein Sequence
MSASKEAAAPAPASNKETSTPVIRVMDMDKMVSPKTKRTGTRMKLLNDVAARPKQEKRTSIKILNNDDAQSSSSKGGDKRATPKTVSPGVKILNEKRIVPAATAMETAKIKTSPSKKKKMDHYVLQAIKSENSKADNTTGVVVVDDEDTIDFILADDDVELGDASKENGDEFVVSGIEDDDDDEDEDDEDDEDGPAGGANGAKRKSGNSSNNNELKEMVEHVCGKCYKTFRRVKSLKKHLEFCRYDSGYHLRKADMLKNLDKIERDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFNDYPCSICNAKLRSAALLKLHEQQHQSRGKPFACKICGKDFTRSYHLKRHQKYSSCSANENDTMSCKVCDRVFYRLDNLRAHLKQHLGTQVVKKPEYMCHVCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYTCTVCSQSFAVKEVLNRHMKRHTGERPHKCNECGKSFIQATQLRTHSKTHLRPYSCSLCIQKFKTEKQLERHVKEHSRQKRASFACSECTRSFRTSALLKEHMDAGDHSPIKPTRAKRTAKVIERTDCAICDKNFDSTETLRNHIRNVHECDPDDIFGTEPPAKRKANKKSAVVLEEEEDEEEEEEANEDKDQDKDTATANTSAGSLISSKTDGNGVVVREFLVDESDGNAQTIVLENEVYTILPLEGAGAGAASTAEPTKEIGEAKADSKEKPQSAVSPVVKREQRKSLAASLAAAIADNLDEPSSDDEFNGEALSEEDIKLKENIAKLIDMLVDPQTLKKYNWPHSSEESVLCKVIENCGHDLAKGSEAYAELDYGSRMREYCKLLFTVVIHNDSIKALLNNFPIDDVIEYVLGDEDQDQDQEADKGKEKENDADKSDAETRQDEADA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00495995;
90% Identity
iTF_00502661;
80% Identity
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