Dmet014959.1
Basic Information
- Insect
- Drosophila mettleri
- Gene Symbol
- Runx1
- Assembly
- GCA_035047625.1
- Location
- JAWNPI010000109.1:14104721-14108593[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 8 1.7e+04 -10.4 8.5 62 75 28 41 12 63 0.60 2 2 2.3e-52 4.9e-49 165.2 0.0 3 96 95 188 93 206 0.94
Sequence Information
- Coding Sequence
- atgcatttgacaACGACGAGCAGCAACTCGACGGCATCTAATGCCAattccaacaacaacacaaacaacaataacaacaacaacaacaacaacacagctAATAACAAcacaaccagcagcaacaacaacaccagcaacacaAATggctccaacaacaacaacaacaacagctcgagcagcaacaacaacacagagCAAAACACACCCCCAACACCCGCCCAGCTATTGAACGAGGCCTACACCAAAATGACCTCCGACATTTTGGCTGAGCGCACATTGGGCGACTTCCTCACCGAGCATCCCGGCGAGCTGATAAGAACCAGCAGTCCCCTCTTCGTCTGCACCGTCCTGCCGCCGCACTGGCGCTCCAATAAGACGCTGCCGGTGGCCTTCAAGGTGGTCTCCCTGGGCGACATCATGGACGGCACCATGGTCACGGTGCGCGCCGGCAACGATGAGAACTACTGCGCCGAGCTGCGCAACTGCACGGCGGTCATGAAGAACCAAGTGGCCAAGTTCAATGATCTGCGATTTGTTGGACGCAGCGGCCGAGGACAGGAGTCCAGCGTCGAGCAGAGACCTGCACCAAAGTCTGTCGCCTCTGCCACAGAATTCATGCACTGTCATTCACTGGACATGCCAATAGCCGCCTGCGCCCATGCCCGGTCGTCCTGTCCCCCGGTCCCCAGCTCTACCACTTGCCATATGCATTCGCATTGA
- Protein Sequence
- MHLTTTSSNSTASNANSNNNTNNNNNNNNNNTANNNTTSSNNNTSNTNGSNNNNNNSSSSNNNTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGQESSVEQRPAPKSVASATEFMHCHSLDMPIAACAHARSSCPPVPSSTTCHMHSH
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- iTF_00548579;
- 80% Identity
- -