Dmer008405.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila merina
Gene Symbol
run
Assembly
GCA_035047645.1
Location
JAWNPH010000054.1:10085083-10113391[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5 2.1e+04 -12.7 9.5 58 77 66 85 58 91 0.67
2 2 9.3e-72 3.8e-68 227.2 0.1 4 129 127 252 124 252 0.98

Sequence Information

Coding Sequence
ATGCACATATCTGCTGAGGTCAGTTCGACCACCTCAAATCAAatacagcagcaacatcagcagcagcagcagcagcagcaacatcagcagcaacagcaacagcagcagcagcagcaacagcagcaacaattgcagcagcaacatcagcaaacAACAAATACCACAACGAAGCGACGCAATGCCGAGTCCtcctccaacaacaacaacaacaatagcacaaacaataacaacaacaataccaccaataacaacaaaaacaacaacaacaataataatacaactaataataataataataataataatgttaAAACAAAACCCGTGGATACGAGTCCCTACTTGACGCCGGAAAATCTCATCGAAAGAACCGTCGATGTCCTTCTTGCCGAACATCCTGGCGAGCTGGTCAAGACGGGATCGCCACATGTGGTCTGCACTACATTGCCCACCCACTGGCGTTCGAATAAGACCCTTCCGATCGCCTTCAAGGTCCTGGCCCTGGGCGAGGTCATGGACGGGACAATAGTCACCATTCGGGCGGGAAACGATGAGAACTTTTGCGGTGAATTGCGAAACTGTACGGCCGTAATGAAGAATCAAGTGGCCAAGTTCAATGACTTGAGATTTGTGGGAAGGAGTGGAAGAGGCAAAAGCTTCACCCTGACAATTGTCATCTCAACGAATCCCATTCAAATAGCCACCTACACGAAGGCCATTAAGGTGACTGTGGATGGACCCAGGGAGCCGAGGTCAAAGGTCAGGCACCAGGGCTTCCATCCATTCGCATTTGGGCCTCAGCGTTTCGGCCCAGATCCTCTTATGGCCGGCTTGCCCTTCAAGTTGCCAGGCTTTGCCCATCACCTGGTGGGAATGCACAGCCACCTGCACGCCCCCGACTGGCGCGCCCACATGGCCTTGGcagcagcggacaatccgcagcagcaggcgcatcagcagcagcagcagcaactggcCCACAGCACCACCAGTCCCGAAGGATctcccaccaccaccaccaccaccagcggCCACACTCAGCTTAGTGCTTTCGTCCAGCCACCCGTTGGATGCTCCTCGCCGCTCCTGGCCCCCCTCACCAGTCTGCAGGATAACGACAatgacaacgacaacaacaacaacactaacaacaacagcaatatCGATGCAGGATTCGAGAGCGACAGCATTTCGGTGACAGGATCGCCGCGAAAGTCCCTGGGCTCGCCCCTCACCCACGACGAGGAGGAAACCGATTCCATATCCCGCGAAGAGAACACGAACCACAATAGTGGGATAGCAGGATCGCTGGGCGAGAGCTCGCCAGGATCGGGCGGAGCCTTCACAGCCCTCATCCAGAGGAGCAAGAATCCAACGGATTTATTCGGTGGCTTCGCCGGGGCAGGAAACGGAAATCACTTCCCGCCCGCGCACAGCTTCAATCCCGCTTTGGCTGCCCAGCTCTTCCTGCAGAGTCCTCTGCTTCCACAGTCCAGCCAGTGGCTGTACAGCCAGCTCTACGGCAGCTACAGTGATCTTCCCTGGCTGAGgaacgccgccgccgccgcagcagcCTCCAATCTCAACCCGAACCCGAACACGCCCACGACCACGCCGGAGGGTGTTCCGCCAGCGAACCAGGACCACGACGGCGTCAACCTCATCAAGCGCTGCGTCACCCTGATCACCCACAATCCCCCCGATGCCGAGAACGCCAATCCCAATGCATCGCCGCCGGTCAGCTCCAGCCGGCGGTCGCCGTCGCCCGTGGAGACCATCGACCTGGACGATGTGAGCACCACCTCCAGGTCGGCCAGTGGGGCGTCCAGTGGTGAGGCAGGCGCTGGTGTGGGTGTCGGAGGAGGACTAGCAGGCAGCGGCGCTGGAGCAGCATCCGGGGGAGGGCCCATCCGGAACAGGACCCCAAAACCTTCGGCGGATGTTTGGCGACCGTACTAG
Protein Sequence
MHISAEVSSTTSNQIQQQHQQQQQQQQHQQQQQQQQQQQQQQQLQQQHQQTTNTTTKRRNAESSSNNNNNNSTNNNNNNTTNNNKNNNNNNNTTNNNNNNNNVKTKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALAAADNPQQQAHQQQQQQLAHSTTSPEGSPTTTTTTSGHTQLSAFVQPPVGCSSPLLAPLTSLQDNDNDNDNNNNTNNNSNIDAGFESDSISVTGSPRKSLGSPLTHDEEETDSISREENTNHNSGIAGSLGESSPGSGGAFTALIQRSKNPTDLFGGFAGAGNGNHFPPAHSFNPALAAQLFLQSPLLPQSSQWLYSQLYGSYSDLPWLRNAAAAAAASNLNPNPNTPTTTPEGVPPANQDHDGVNLIKRCVTLITHNPPDAENANPNASPPVSSSRRSPSPVETIDLDDVSTTSRSASGASSGEAGAGVGVGGGLAGSGAGAASGGGPIRNRTPKPSADVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00550040;
90% Identity
iTF_00614690;
80% Identity
-