Basic Information

Insect: Drosophila meridionalis
Gene Symbol: hb
Assembly: GCA_035045145.1
Location: JAWNPG010000037.1:4778556-4781009[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00021 0.014 15.9 0.2 1 23 259 281 259 281 0.99

2 6 0.007 0.49 11.0 4.5 2 23 289 310 288 310 0.97

3 6 0.0003 0.021 15.3 5.0 1 23 316 338 316 338 0.98

4 6 0.039 2.8 8.7 5.3 1 23 344 368 344 368 0.93

5 6 0.00024 0.017 15.6 0.4 1 23 764 786 764 786 0.96

6 6 0.0035 0.25 12.0 0.2 1 22 792 813 792 816 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00021	0.014	15.9	0.2	1	23	259	281	259	281	0.99
2	6	0.007	0.49	11.0	4.5	2	23	289	310	288	310	0.97
3	6	0.0003	0.021	15.3	5.0	1	23	316	338	316	338	0.98
4	6	0.039	2.8	8.7	5.3	1	23	344	368	344	368	0.93
5	6	0.00024	0.017	15.6	0.4	1	23	764	786	764	786	0.96
6	6	0.0035	0.25	12.0	0.2	1	22	792	813	792	816	0.91

Sequence Information

Coding Sequence: ATGCCTAACTGGGAGACGAGCGCCGCGGCGCCCAACTACGAGCAGCACAATGCCTGGTACAGCAGCATGTTTGCTGCCAACATCAAGCAGGAGCCCATGTCGCATCACCACAGCCATCATCACGATgccagcaacagtaacagcaacagcggagCGAGCAGCCCGAGGCAATCGCCGCTGCCTTCACCCAATGCGCCCAGCACCCAGCTGGAGCAGTACCTcaagcaacagcatcagcagcagcagcagcagcaccagcagcccATGGATACGATGTGCGCGGCTGCCATGACGCCGTCGCCGAGCAACAATGATCAGAACAGCATACAGCACTTCGACACCACActccagcagcaactgttgcagcagcagcagtaccaGCAACACTTTCAGGCGgcacagcaccagcagcagcagcaccatcaTCTCGCACTGGGTGGCTTCAATCCGCTGACGCCGCCGGGTCTGCCCAATCCCATGCAGCACTACTATGCCAGCAACATGCGCCCCAGTCCACagcccacgcccacagccaTCCCCTCGACGGTGGCAACGGCTATTCAGACCGGCGACAAGCTGCAGGCGCTGACGCCGCCAATGGACGTCACGCCGCCCAAGTCACCGGCCAAGTCGCAGCAGTCGAGCGTGGAGCCAGAGAAGGAGCACGATCTGATGTCGAACTCCAGCGAGGACATGAAGTACATGGCCGAGTCCGAGGACGACGACAGCAACATTCGCATGCCCATCTACAACTCGCACGGCAAGATGAAGAACTACAAGTGCAAGACATGCGGCGTCGTGGCCATCACCAAGGTGGACTTCTGGGCGCATACGCGCACCCACATGAAGCCCGACAAGATACTGCAGTGCTCCAAGTGCCCCTTCGTCACGGAGTTCAAGCATCATCTGGAGTACCACATACGCAAGCACAAGAACCAAAAGCCCTTCCAGTGCGACAAGTGCAGCTACACCTGCGTGAACAAGTCCATGCTGAACTCCCACCGGAAGTCGCACAGCTCCGTCTACCAATACCGCTGCGCCGACTGCGACTATGCCACCAAGTACTGTCACAGCTTCAAGCTGCATCTGCGCAAGTATGGCCACAAGCCCGGCATGGTGTTGGACGAGGATGGCACGCCCAATCCCTCCCTGGTCATCGATGTCTATGGCACACGGCGCGGACCCAAGAGCAAGTCCTTTTCGGGCAGCAGCTCCAACTGTGGCGGTTCCAGCAAGCGTAGCAGCGCATCGGCTGCCGcccagcagcaccaacaacagcagcagcagcagcagcagccacagcatcaaccacagcaacaacaacagcctgTGCTGCCACCGAGCGCAACATCTCAGCTATCCGCCGCGCTCCAAGGATTTCCcttaccagcagcagcagcagccgccgcaacagcagcaccgcCAGCAGCTGTGGCTCCCGTCTCCCCACCGTCGCCGGCCAAGAGCGTGGCCAGCGTTGAGCAGGCGCCCAGCCTGTCCAGTGCTCTGCTGCCGCCGTTGGCCAGCCTGCTTCAGCAGAACCGCAACATGGCCTTCTTCCCCTACTGGAATCTCAATCTGCAGATGCTCGCTGCTCAGCAGCAGGCCGCCGTTCTGGCACAGTTGTCGCCGCGCATGCGTGACCAgctgcagcggcaacagcagcagcaacaccaacagcagcagcagcagcaacaacaacagcaactgccagCTCACAGCGACAACGAGGAGGACGAGCACGACGATGAGTTCGAGCGCAAGTCCGTGGACTCTGCCATGGATCTGTCGCAAGGCACTCCGGTCAAGGaggagccgcagcagcagcatcagcccCACAGCAACCACATGGCCATCAACCTGAAGCTGAAAGACGACGACACGCCGctgatcagcagcagcagcacctccCGCCGCAAGGGTCGTGTCCTGAAGCTGGAcacgctgctgcagctgaaatCGGCTGCCATGTCATCGCCGGAACAGCAATTGAAACTGCCGCCAAGTGTTTTGCCCACGGCCTCGTCGCCCATTGccggcagcagcgccaacaagCAGCTGGCGGATGATCCGTGCTCGGGTGCCAGCTCAGCGGACGAGTCCATGGAAACGGGCCGTGTGCCACAGGCCAACACGAGCGCCAGCTCCACGGCCTCCAGCTCCGGTAACAGCTCGAATgctagcagcaacagcaatgcggCTCCAGCTGCCGCCGTCGCCACCTCCGCCACCGTATCGAGCTCATCCGCATCCACGGCCACatccaccagcagcagcgctccGGCCATATACGAGTGCAAGTATTGTGATATTTACTTCAAGGACGCTGTGCTCTACACAATCCACATGGGGTATCACAGCTGCGACGACGTCTTCAAGTGCAACATGTGCGGCGAGAAGTGCGACGGACCCGTCGGCCTCTTCGTTCACATGGCCCGCAATGCGCACTCCTAA
Protein Sequence: MPNWETSAAAPNYEQHNAWYSSMFAANIKQEPMSHHHSHHHDASNSNSNSGASSPRQSPLPSPNAPSTQLEQYLKQQHQQQQQQHQQPMDTMCAAAMTPSPSNNDQNSIQHFDTTLQQQLLQQQQYQQHFQAAQHQQQQHHHLALGGFNPLTPPGLPNPMQHYYASNMRPSPQPTPTAIPSTVATAIQTGDKLQALTPPMDVTPPKSPAKSQQSSVEPEKEHDLMSNSSEDMKYMAESEDDDSNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCSKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGTPNPSLVIDVYGTRRGPKSKSFSGSSSNCGGSSKRSSASAAAQQHQQQQQQQQQPQHQPQQQQQPVLPPSATSQLSAALQGFPLPAAAAAAATAAPPAAVAPVSPPSPAKSVASVEQAPSLSSALLPPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMRDQLQRQQQQQHQQQQQQQQQQQLPAHSDNEEDEHDDEFERKSVDSAMDLSQGTPVKEEPQQQHQPHSNHMAINLKLKDDDTPLISSSSTSRRKGRVLKLDTLLQLKSAAMSSPEQQLKLPPSVLPTASSPIAGSSANKQLADDPCSGASSADESMETGRVPQANTSASSTASSSGNSSNASSNSNAAPAAAVATSATVSSSSASTATSTSSSAPAIYECKYCDIYFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00547606;
90% Identity: iTF_00540649;
80% Identity: -