Dmer000158.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila meridionalis
Gene Symbol
-
Assembly
GCA_035045145.1
Location
JAWNPG010000003.1:1781965-1783377[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 3.5e-06 0.00025 21.4 0.8 3 23 219 240 218 240 0.96
2 6 0.0001 0.0072 16.8 3.7 1 23 248 271 248 271 0.94
3 6 8.1e-05 0.0057 17.1 0.3 1 23 277 299 277 299 0.97
4 6 1.8e-06 0.00013 22.3 0.5 1 23 308 330 308 330 0.97
5 6 2.5e-05 0.0017 18.7 4.8 1 23 339 361 339 361 0.98
6 6 3e-05 0.0021 18.5 0.7 1 23 367 390 367 390 0.96

Sequence Information

Coding Sequence
ATGTTCCCGCTGCTGAATCACTCGGTCTTTGTGGTCTGCCGTTGCTGCCTGGTGGAACAGCCGCAGTACTGCCACAGCATATGCGACAATGATCAACTGCTCAGCCAGCTGCTCGCGCTGTCGCCCACTCTTCAGATTGTACCCAGCGACGTCATCTGCGAGCTCTGTCTGCATCGACTTCATGACGCCCTTGATTTTCGACAGCGCTGCGAGGAATCGGAGCGCATTATACGCGCCCGCAACGAACAGGCGTTGGACGACGCACTTGAGTGCCTCGAGAGAGAGGTCGGCTGCCTGGAGCAAGCCAaatccatgtccatgtccaaaGCTATGCCAACGCTGCCGGAACCTGTTGACTTTGGTACCCTGGATCTGTCGGATTTGTTTCGGGGCAATCAGGATCAGCCCAACACAACGATGGCAACCTGGGACGCGGCCACCCTAAATACGCCCATCCACTTGCCAGGCAACCTGGAGCCATTGAAGActgcagaagaagaagatgatgatgaagagaAGAGGAACGGCGAATCTGCTTGTGCGTTTGATCTCGTTGTGCCGCCCAAGCGAAAGAGGCCGCCACgcaaggcagcaacaacagccggcGGCAATGGGACAGGCGTACGCAGCCGGACGCCAAAGTCGTTACGCCCGTGCACCGAGTGCGAAAAGAAGTTTACGCGTAATTTCCAGCTGAAGCTGCACATGATATCGGTGCATGGGCTGGGCGACGGGCTGCGGTACAAGTGCGAGGTGTGCTCGAAAAGCTTTGCATCGCGCCACAGCCTGCGCTATCATTTTACGTCACTGCACTCAACTGAGCGTCCATTCGCCTGCGAACTGTGCGATCGACGGTTTGTGCTGCGCACCCAACTGATCTCGCACGCCCGTATGCACACAGGCGAAACGAAGCCGCGCATCTTCGACTGCACTGTGTGCGGCAAGACGTGGCCCACAAAATCGGATCTGCGCACCCACATGCGCTCCCACGATCCGGACATGTCCAAGCGACCCTACAAATGTGATCAGTGCAACAAGGCCTTCTTCACGCGCGGCCACCTCAACTCTCACCACTTGGTGCACACCGGCGAAAAGCCCTACGCCTGCACGTACTGCGACAAGTCATATCAGAGCGTTGGCAATCTCAACAATCACACACTGAGGCAGCACTCGAATCTGATTGAGACGCAGCTGAATCTCAAATACACCGACTTTGAGAGCTAA
Protein Sequence
MFPLLNHSVFVVCRCCLVEQPQYCHSICDNDQLLSQLLALSPTLQIVPSDVICELCLHRLHDALDFRQRCEESERIIRARNEQALDDALECLEREVGCLEQAKSMSMSKAMPTLPEPVDFGTLDLSDLFRGNQDQPNTTMATWDAATLNTPIHLPGNLEPLKTAEEEDDDEEKRNGESACAFDLVVPPKRKRPPRKAATTAGGNGTGVRSRTPKSLRPCTECEKKFTRNFQLKLHMISVHGLGDGLRYKCEVCSKSFASRHSLRYHFTSLHSTERPFACELCDRRFVLRTQLISHARMHTGETKPRIFDCTVCGKTWPTKSDLRTHMRSHDPDMSKRPYKCDQCNKAFFTRGHLNSHHLVHTGEKPYACTYCDKSYQSVGNLNNHTLRQHSNLIETQLNLKYTDFES