Basic Information

Insect: Drosophila meridionalis
Gene Symbol: zfh1
Assembly: GCA_035045145.1
Location: JAWNPG010000020.1:10012527-10040724[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0071 0.5 11.0 1.8 2 23 73 95 72 95 0.94

2 9 0.0014 0.095 13.3 0.1 1 23 292 314 292 314 0.97

3 9 3.2e-05 0.0023 18.4 1.8 2 23 328 349 327 349 0.97

4 9 1.1e-05 0.0008 19.8 6.4 1 23 358 380 358 380 0.99

5 9 0.00033 0.023 15.2 1.2 3 21 388 406 386 407 0.94

6 9 0.03 2.1 9.0 0.4 2 21 634 653 633 654 0.92

7 9 1.5e-05 0.001 19.4 0.5 1 23 1012 1034 1012 1034 0.94

8 9 5.6e-05 0.0039 17.6 7.4 1 23 1040 1062 1040 1062 0.98

9 9 0.0028 0.2 12.3 4.3 1 21 1068 1088 1068 1089 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0071	0.5	11.0	1.8	2	23	73	95	72	95	0.94
2	9	0.0014	0.095	13.3	0.1	1	23	292	314	292	314	0.97
3	9	3.2e-05	0.0023	18.4	1.8	2	23	328	349	327	349	0.97
4	9	1.1e-05	0.0008	19.8	6.4	1	23	358	380	358	380	0.99
5	9	0.00033	0.023	15.2	1.2	3	21	388	406	386	407	0.94
6	9	0.03	2.1	9.0	0.4	2	21	634	653	633	654	0.92
7	9	1.5e-05	0.001	19.4	0.5	1	23	1012	1034	1012	1034	0.94
8	9	5.6e-05	0.0039	17.6	7.4	1	23	1040	1062	1040	1062	0.98
9	9	0.0028	0.2	12.3	4.3	1	21	1068	1088	1068	1089	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTTCCTCTTTGGCCTCCAGTTTGCATCACCACCAAGCCCACAACAAGCCCAGCAATGTGGCCGCCAACCCAGAGCTGGCCAGCAGCGCCACAGGCAGCGCAGCCGAGGACTGTCCGGTCAAGTGCACGCAGTGCCACAAGCGCTTCTCGGAGCTGCAGTCCTTCAGCGAGCACATTGCCAACGAGCATCCGCACGACAAACTCAACTACGAGCCGCATCGGGCCGCAGCTGAGGCTGCGCAGCCGGAGAGCGAGGCGGAGGAGGATGAGCAGAGCAATTTGAGCAGTAGCAGTCGGCGCTATGCCAAATCTcccagcaccaacaacaacaacaacaacaatgacaacaacaacagcgagacAGCAAAGaatcaaaataacaacaataacagcaacagcgacagccaTAGAAGCCAGCACTCGCCTCTCTTCTCGCCCATTGCGGCCACAGTCAACGATCTGTTTGCCCACATGCGGCACACGCCGCCGCAGCTGCCCAGCCATTTGCACTCGCAGTTCATGGCCGCCGCTGCTTTGGCCATGCAATCCGCCCGATCCACTAGTTCgcccagccagcagcagcagcaacagcagcagcaacaattgcagcagcagcagcagcaacagtcgccgcagttgcagcaggcgttgctgctgccgccgcctcagcccggcagcaacagcagcgtcgGCAGCAACTCCGCCTACGACCTGGACTTGAGTGCGCCACGCTCCACCTCCAGCCCGGGCTCCACAACGGGCGACCTGGGCGCCGCCTTCCCCTGCATGCAGTGCACCGCTGCCTTCGCCAGCCGCGAGCAGCTCGAgcagcaccagctgctgcACTCGCCCACGGGACCGCAGACCGCACAAAATGTGACACAGACCTGCAAAATATGCCACAAGGCCTTCGCGAACGTGTACCGCCTCCAGCGGCACATGATCAGCCACGACGAGTCCGCGCTGCTGCGCAAGTTCAAGTGCAACCAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGCTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCGAAGAAGTGCATCAGCATGGGCCTCAAGCTCAACAACAATCGCCAGATGCTCAAGACTCTGGACAAGAACTCGAGCGCCCGACGCTCACCCAcggatcaacagcagcagcagcagctggcgggcAAGCGAAAGCTGCCCGAGCAGGTGCTGCCCAATCCCATGAACTACTTTGCCGGCGAAGTGCAGAATCCACCCGCAAGTGTCAATGCTCCTGCGCCCTTCTACCCCAACTACATGAATGCGGCGCTGTTGGCGTTTCCAAATGCGATCATGGCTGCCGCGCTGGATCCCCGCATGCATCCCTACAGCATACAGCGACTGCTGCAGTTGACTGCTGccgggcagcagcaacagcagcagcagcaccagcgggaggagcagctggagcaggagcacaGGGAGGAGCAGAAACTGTACGAGACCGGAAAGGATGACGATGAGACGCCAGATGAGCCCAAGTTAGTTATGGATTTGGAAGAGGCGGAACCCAAGCCTGCGGCCAGCCCTGAGCTGCCCGTTGCTGAGCCAGCAACTGTCGACGTGGGCGTGGTCAAGCAGGAGCCCAGTCGCGAGCCGACGCCTCCGGACACGCCCAAGTCCATCAAGGTGGAGCATGAAGAGGAGCTGGAGCCGGTGGTTGCCGTGGAGCAGTCGCGGGTGCAGACACCTCAAGAGCTACGCTGCAGCCGCTGTGCCAAGCAGTTCAATCATCCCACAGAGCTGGTGCAGCACGAGAAGGTGCTGTGCGGCCTGATCAaggaggagctggagcagcaataccagcaacaacatcaacagcagcaacaacatcaacaacaacatcaacagcaacaacaacagcagcagcagcagcagcaacaacagtcgAACTTTGCTTTGCTGCCCTCCACCAGCGATGCGGACGAGGATGAGGAGGACGAGGAAGAGCCGCGCCAGGATTACCACGccggcagcagcgacagcggcgaGCGCAAGGTGCGCGTGCGCACCGCCATCaacgaggagcagcagcagcagctgaagcagcacTACGCCCACAATGCGCGTCCCAGCCGGGATGAGTTCCGCCTGATCGCCGCCCGCCTGCAGCTGGACGCGCGCGTCGTCCAGGTCTGGTTCCAGAACAATCGCTCGCGCGAACGCAAGCTGCAGAGCTACGCAAGCAACGGCGAGgccacagctgctgctccgaGCCAACCGCAGCCACGCGCTGGCGAGGATCAGCCGCTGGACTTGTCCGTGAAACGCGATGCTTCGCCGCTGTTTGGCCTGGCAGCGTCCCAGCAGGCAGCCGTGCTGCCCGCGCCCGCTGACTTCCAGGAGACCATGGCCATCAATCTGAGCCGCAAGCTCTCCGGCTCGGCGTCCATGTCGCCAGCCTCGCTCTCGCCCTGCTCGGGCGCCTCCTCGCTGCAGCAgtcggcggcagcagctgctgctgctgcagcgctctACTTTGCGCCACCCTCGCCGCCCGGCCTGCACGAGTCGGCGGCCGCCGCAGCACCGCGTGGCCAGGCCTTCGCCGGCATGCCGCCGTACATGCTGCCGCGCCTGCCCATGGAAGCGCTCTTCCAGATGCGGCCCGGCGGCGACTATGCGCCCAATCCGCTCATGAACAGTATTAAGCTGCCCGACTATCGCGGCACCAGCCTGAGCCCCGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGACGACTCGCGCATCTCGCACGACGAGGACTACGTGGTGGCGAGCGGCGGCCTGCTGCCGCCCAAGCCGAAGCGGGCCAAGGCCGAGACGCACGGCCATGCGGGCGATCCGGATCTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCGCTGGCGCGCCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCCAAGGCCTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGTCTGCATTCCGGCGAGAAGCCATTCCAGTGCTCCAAGTGCCTGAAGCGCTTCTCCCACTCGGGCAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFSSLASSLHHHQAHNKPSNVAANPELASSATGSAAEDCPVKCTQCHKRFSELQSFSEHIANEHPHDKLNYEPHRAAAEAAQPESEAEEDEQSNLSSSSRRYAKSPSTNNNNNNNDNNNSETAKNQNNNNNSNSDSHRSQHSPLFSPIAATVNDLFAHMRHTPPQLPSHLHSQFMAAAALAMQSARSTSSPSQQQQQQQQQQLQQQQQQQSPQLQQALLLPPPQPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLGAAFPCMQCTAAFASREQLEQHQLLHSPTGPQTAQNVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCNQCDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRQMLKTLDKNSSARRSPTDQQQQQQLAGKRKLPEQVLPNPMNYFAGEVQNPPASVNAPAPFYPNYMNAALLAFPNAIMAAALDPRMHPYSIQRLLQLTAAGQQQQQQQHQREEQLEQEHREEQKLYETGKDDDETPDEPKLVMDLEEAEPKPAASPELPVAEPATVDVGVVKQEPSREPTPPDTPKSIKVEHEEELEPVVAVEQSRVQTPQELRCSRCAKQFNHPTELVQHEKVLCGLIKEELEQQYQQQHQQQQQHQQQHQQQQQQQQQQQQQQSNFALLPSTSDADEDEEDEEEPRQDYHAGSSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKLQSYASNGEATAAAPSQPQPRAGEDQPLDLSVKRDASPLFGLAASQQAAVLPAPADFQETMAINLSRKLSGSASMSPASLSPCSGASSLQQSAAAAAAAAALYFAPPSPPGLHESAAAAAPRGQAFAGMPPYMLPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHDEDYVVASGGLLPPKPKRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00530857;
90% Identity: iTF_00559678;
80% Identity: iTF_00545138;