Basic Information

Insect: Drosophila meridiana
Gene Symbol: zfh1
Assembly: GCA_035045185.1
Location: JAWNPF010000055.1:24762496-24791530[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0071 0.53 11.0 1.8 2 23 73 95 72 95 0.94

2 9 0.0013 0.1 13.3 0.1 1 23 292 314 292 314 0.97

3 9 3.2e-05 0.0024 18.4 1.8 2 23 328 349 327 349 0.97

4 9 1.1e-05 0.00085 19.8 6.4 1 23 358 380 358 380 0.99

5 9 0.00033 0.025 15.2 1.2 3 21 388 406 386 407 0.94

6 9 0.03 2.2 9.1 0.4 2 21 634 653 633 654 0.92

7 9 1.5e-05 0.0011 19.5 0.5 1 23 1010 1032 1010 1032 0.94

8 9 5.5e-05 0.0041 17.7 7.4 1 23 1038 1060 1038 1060 0.98

9 9 0.0028 0.21 12.3 4.3 1 21 1066 1086 1066 1087 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0071	0.53	11.0	1.8	2	23	73	95	72	95	0.94
2	9	0.0013	0.1	13.3	0.1	1	23	292	314	292	314	0.97
3	9	3.2e-05	0.0024	18.4	1.8	2	23	328	349	327	349	0.97
4	9	1.1e-05	0.00085	19.8	6.4	1	23	358	380	358	380	0.99
5	9	0.00033	0.025	15.2	1.2	3	21	388	406	386	407	0.94
6	9	0.03	2.2	9.1	0.4	2	21	634	653	633	654	0.92
7	9	1.5e-05	0.0011	19.5	0.5	1	23	1010	1032	1010	1032	0.94
8	9	5.5e-05	0.0041	17.7	7.4	1	23	1038	1060	1038	1060	0.98
9	9	0.0028	0.21	12.3	4.3	1	21	1066	1086	1066	1087	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTTCCTCTTTGGCCTCCAGTTTGCATCACCACCAAGCCCACAACAAGCCCAGCAATGTGGCCGCCAACCCAGAGCTGGCCAGCAGCGCCACAGGCAGCGCAGCCGAGGACTGTCCGGTCAAGTGCACGCAGTGCCACAAGCGCTTCTCGGAGCTGCAGTCCTTCAGCGAGCACATTGCCAACGAGCATCCGCACGACAAACTCAACTACGAGCCGCATCGAGCTGCCGCTGAGGCTGCGCAGCCGGAGAGCGAGGCGGAGGAGGATGAGCAGAGCAatttgagcagcagcagtcggcgCTATGCCAAATCTcccagcaccaacaacaacaacaacaatgacaacaacaacagcgaggcAGCAAAGAatcaaaataacaacaacaacagcaacagcgacagccaTAGAAGCCAGCACTCGCCTCTCTTCTCGCCCATTGCGGCCACAGTCAACGATCTGTTTGCCCACATGCGGCACACGCCGCCGCAGCTGCCCAGCCATTTGCACACGCAGTTCATGGCCGCCGCTGCTTTGGCCATGCAATCCGCCCGATCCACCAGTTCgcccagccagcagcagcagcaacagcagcacctgcagcaacagcaacagcagcagcagcaacagtcgccgcagctgcagcaggcgttgctgctgccgccgcctcaacccggcagcaacagcagcgtcgGCAGCAACTCCGCCTACGACCTGGACTTGAGTGCGCCACGCTCCACCTCCAGCCCGGGCTCCACAACGGGCGACCTGGGCGCCGCCTTCCCCTGCATGCAGTGCACCGCCGCCTTCGCCAGCCGCGAGCAGCTCGAGCAGCACCAGCTGCTGCACTCGCCCACGGGACCGCAGACCGCACAAAATGTGACACAGACCTGCAAAATATGCCACAAGGCCTTCGCGAACGTGTACCGCCTCCAGCGGCACATGATCAGCCACGACGAGTCCGCGCTGCTGCGCAAATTCAAGTGCAACCAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGCTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCGAAGAAGTGCATCAGCATGGGCCTCAAGCTCAACAACAATCGCCAGATGCTCAAGACTCTGGACAAGAACTCGAGCGCCCGACGCTCACCCAcggatcagcagcagcagcagcagctggcgggCAAGCGAAAGCTGCCCGAGCAGGTGCTGCCCAATCCCATGAACTACTTTGCCGGCGAAGTGCAGAACCCACCCGCAAGTGTCAATGCTCCTGCGCCCTTCTACCCCAACTACATGAATGCGGCGCTGTTGGCGTTTCCGAACGCGATCATGGCTGCCGCGCTGGATCCCCGCATGCATCCCTACAGCATACAGCGACTGCTGCAACTGACTGCTGccgggcagcagcaacagcagcagcagcaccagcgggaggagcagctggagcaggagcacaGGGAGGAGCAGAAACTGTACGAGACCGGAAAGGATGACGATGAGACGCCCGATGAGCCCAAGTTAGTTATGGATTTGGAAGAGGCGGAACCCAAGCCTGCGGCCAGCCCTGAACTGCCCGTTGCTGAGCCAGCAGCTGTCGACGTGGGCGTGGTCAAGCAGGAGCCCAGTCGCGAGCCGACGCCTCCGGACACGCCCAAGTCCATCAAGGTGGAGCATGAGGAGGAGCTGGAGCCAGTGGTTGCCGTGGAGCAGTCGCGGGCGCAGACACCTCaagagctgcgctgcagccgctgtgccaagcagttcaaTCATCCCACAGAGCTGGTGCAGCACGAGAAGGTGCTGTGCGGCCTGATCAAGGAGGAGCTAGAGCAGCAataccagcaacaacatcaacaacatcaacagcagcaacaacagcaacaacaacaacagcagcagcaacaacaacaacaacagtcgaGCTTTGCTTTGCTGCCCTCCACCAGCGATGCGGACGAGGATGAGGAGGACGAGGAAGAGCCGCGCCAGGATTACCACGccggcagcagcgacagcggcgaGCGCAAGGTGCGCGTGCGCACCGCCATCaacgaggagcagcagcagcagctgaagcagcaCTACGCCCACAATGCACGTCCCAGCCGGGATGAGTTCCGCCTGATCGCCGCCCGCCTGCAGCTGGACGCGCGCGTCGTCCAGGTCTGGTTCCAGAACAATCGTTCGCGCGAACGCAAGCTGCAGAGCTACGCAAGCAACGGCGAGgccacagctgctgctccgaGCCAACCGCAGCCACGCGCTGGCGAGGATCAGCCGCTGGACTTGTCCGTGAAGCGCGACGCTTCGCCTCTGTTTGGCCTGGCGGCGTCCCAGCAGGCAGCCGTGCTGCCCGCGCCCGCTGACTTCCAGGAGACCATGGCCATCAATCTGAGCCGCAAGCTCTCCGGCTCGGCGTCCATGTCGCCGGCCTCGCTGTCGCCCTGCTCGGGTGCCTCCTCGCTGCAGCAgtcggcggcagcagcggctgctgctgcagcgctcTACTTTGCGCCACCCTCGCCGCCCGGCCTGCACGAGTCGGCGGCCGCCGCAGCACCGCGTGGCCAGGCCTTCGCCGGCATGCCGCCGTACATGCTGCCGCGCCTGCCCATGGAAGCGCTCTTCCAGATGCGGCCCGGCGGCGACTATGCGCCCAATCCGCTCATGAACAGTATTAAGCTGCCCGACTATCGCGGCACCAGCCTGAGCCCCGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGACGACTCGCGCATCTCGCACGACGAGGACTACGTGCTGGCGAGCGGCGGCCTGCTGCCGCCCAAGCCGAAGCGGGCCAAGGCCGAGACGCACGGCCATGCGGGCGATCCCGATCTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCGCTGGCGCGCCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGTCCCAAGGCCTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGTCTGCATTCCGGCGAGAAGCCATTCCAGTGCTCCAAGTGCCTGAAGCGCTTCTCCCACTCGGGCAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFSSLASSLHHHQAHNKPSNVAANPELASSATGSAAEDCPVKCTQCHKRFSELQSFSEHIANEHPHDKLNYEPHRAAAEAAQPESEAEEDEQSNLSSSSRRYAKSPSTNNNNNNDNNNSEAAKNQNNNNNSNSDSHRSQHSPLFSPIAATVNDLFAHMRHTPPQLPSHLHTQFMAAAALAMQSARSTSSPSQQQQQQQHLQQQQQQQQQQSPQLQQALLLPPPQPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLGAAFPCMQCTAAFASREQLEQHQLLHSPTGPQTAQNVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCNQCDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRQMLKTLDKNSSARRSPTDQQQQQQLAGKRKLPEQVLPNPMNYFAGEVQNPPASVNAPAPFYPNYMNAALLAFPNAIMAAALDPRMHPYSIQRLLQLTAAGQQQQQQQHQREEQLEQEHREEQKLYETGKDDDETPDEPKLVMDLEEAEPKPAASPELPVAEPAAVDVGVVKQEPSREPTPPDTPKSIKVEHEEELEPVVAVEQSRAQTPQELRCSRCAKQFNHPTELVQHEKVLCGLIKEELEQQYQQQHQQHQQQQQQQQQQQQQQQQQQQSSFALLPSTSDADEDEEDEEEPRQDYHAGSSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKLQSYASNGEATAAAPSQPQPRAGEDQPLDLSVKRDASPLFGLAASQQAAVLPAPADFQETMAINLSRKLSGSASMSPASLSPCSGASSLQQSAAAAAAAAALYFAPPSPPGLHESAAAAAPRGQAFAGMPPYMLPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHDEDYVLASGGLLPPKPKRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00530857;
90% Identity: iTF_00559678;
80% Identity: iTF_00544384;