Dmer014086.3
Basic Information
- Insect
- Drosophila meridiana
- Gene Symbol
- ewg
- Assembly
- GCA_035045185.1
- Location
- JAWNPF010000165.1:6133641-6138154[+]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 6.6e-108 3.3e-104 347.4 0.0 1 212 156 366 156 367 0.98 2 5 4 2e+04 -5.0 9.0 87 136 481 531 468 548 0.61 3 5 0.43 2.2e+03 -1.7 0.1 98 134 562 598 546 610 0.69 4 5 1.8 9.1e+03 -3.7 1.0 3 14 780 791 778 796 0.78 5 5 1.4 7.3e+03 -3.4 0.6 87 119 839 873 830 890 0.50
Sequence Information
- Coding Sequence
- ATGCGACTAGCGCGACGTAGTTTAGGAGCCGAACGAATTGCAACCACCAGCACCACAAGTGCCACAGCCACCAAGCTGGCAACCACAAGCTATCGGCTGGTTGTGGCGCCGGCTGGCAGCCAAAGGAGCGCTGGCAATGTGGTCGTCAGCAGCGTCAGCGGTGGCGCCACCGTTACGGGCAACACCATTGTCACGacgggcaacaacagcaatagctccggcagcggcggcggtgcGCTGAACGTGACCACAATCACAACCACCAGCAACAGCTCGCAGGCGCAGTCGTCATCCGGTGGCCAGAGCAATGGCACCACCTACAAAATCGAGATGCTCGACGACGACATGCAGAGTCTGGCCACAGATGACGAGGACGACGATTTGATTAGCAGCGAGGGCAGTTTATACGATGGCGATCTCAATACGCTGCCCAACGACGATGTCGCCCATCAGCTGGCGGCTGCTgggccagtgggcgtggcagcggccGCCGCCATTGCCAGCTCAAAGAAACGCAAGCGTCCGCACTGCTTCGAAACGAATCCGTCGGTGCGCAAGCGGCAGCAGAATCGTCTACTGCGCAAGCTGCGCGGCATCATCTACGAGTTCACTGGGCGCGTCGGCAAGCAggcggtggtgctggtggcgACGCCGGGCAAGCCGAACACCAGCTACAAGGTGTTCGGCGCCAAGCCGCTGGAGGATGTGCTGCGCAATCTGAAGAACATTGTGATGGATGAGCTGGACAATGCACTGGCGCAGCaggcgccgccgccgccacaaGAGGATCCCTCGCTGTTCGAGCTGCCCGGCCTGGTCATCGACGGCATACCGACGCCCGTCGAAAAGATGACGCAGGCGCAGCTGCGTGCGTTCATACCGCTCATGCTCAAGTATTCGACGGGACGGGGCAAGCCGGGCTGGGGACGAGAGTCGACGCGGCCGCCATGGTGGCCCAAGGAGTTGCCGTGGGCGAATGTGCGAATGGATGCCCGCTCGGAGGATGACAAGCAGAAGATCAGCTGGACCCATGCGCTGCGCAAGATTGTGATCAACTGCTACAAGTATCATGGACGCGAGGATCTGCTGCCGACATTCGCCGACGACGAGGACAAGGTGAATGCGCTCATTTCGCAGTCCggcgacgaggacgaggacatGGAGCAGCTATCCAATACGCCCACCATACAGACGGTGCAAACGGTGACGCCGGCCACCAATCAAACCACCAGCCAAcaactgcagccacAGCAGGTGAACGTGGTGAAGATCAACAGCGCCGGCACAGTGATCACAACGCACACAGCCCAATCGAATACGCCAGCTCCGACGATCATCCAGAGCACGAACAATCAGCATGTGACCACGACAGCCACGTTGCCAGCGTCGACGAAGATCGAGATATGCCAGGCGCCagcgccacagcagcaacagcagcagcagcatcaccatcatcagcagcagcagcaacagcagcagcagcaacaacaccatcaccaacagcagcaccatcagcagcaacatctgcacaccaccagcaacaacaacacgaccACTGTGCACATCCAGGCCGTCAGCCAGGCGCAGCCGCAAACGATTCAGCTGACAACGGCGAGCGGCACGGCCACGGCGACGGCTGTGCCGACAACAGCGGCCGCTGTAAGTGCTTCACAGGCGGCACAGGCGGCTGCCGCAgctgcacagcagcagcagcaatcgaaTGCAGCTCAGACCGTAACCGCCCAACAGATAGCCAATGCCCAAGTTTGCATCGAGCCCATAACGCTGAGCGACGTTGATTACACAACACAAACTGTTTTGTCGCAGAACGCCGATGGCACCGTCTCTCTCATACAGGTGGATCCTAACAATCCGATCATAACGCTGCCCGATGGCACAACGGCTCAGGTTCAGGGCGTGGCAACGCTGCATCAAGGCGAAGGCGGCGCCACCATACAAACGGTACAAAGTCTCGCCGATGTGAACGGTCATGATAATATGACCGTCGATCTGACCGAGGCGCAGGATGGTCAAATCTTTATCACCACCGAGGATGGGCAAGGATATCCGGTGTCAGTGAGCAATGTTATATCGGTGCCCGTCTCCATGTATCAGTCGGTGATGGCCaacatgcagcagctgcagacgAATAGCGATGGCACCGTGTGCCTGGCCCCCATGCAGGTAGATAACAGCAAcacatcaaacaacaacaacaccaacaacaacaacagcagcggcaataataataatagtagtagcGGCAGCGCAGCTATTGCTGCGCCCACTTCGCTGCTAGGCATCTCAGTAATCAACGCTGGCGCCATGCTAGGTCGGCGCGGCgtcgcagcggcagcggcaacgtcAAGTGCCGGACAACAGCCGGCGCTGACATTGCAAGCGCCGCCTGGCACTCGTTTCTATTGGGCTGCGAATTCAGGCGGCGGCGCTGGCagcagcaatttaaatgctaCCACTAGCTTTAATCTCAcccataacaataacaataacaatagcatGCTtactaacaacaataataacaacaacaacaacaacaacaacagtaacagtagcagcagtagcaataataacattaaaatgaCGCTGCCCATAGTGCTGACAGCGCCAGcgacgtcgactgcgcagCGGCGTCAAGAACCGAATTCGCCGCGACGCACAGCAGCGCAAAAACGGCGCAagctgaacaacaacaacaacagcaacagcaacgtcgacagcagcagtagcaacagcaacaacaacaataataagcTAACTTTGCGCAAAAAAGTTAGCGATATAACGGTACCTggcgctgctactgctgccgctgcagctgagCCGTCTACCATACGCTGCGTGGACAGCGCCAGTCTAACAAAtgccagcggcggcagcgcaggcttgcagttgcagctgccggCCATTAAATTAGAGCATTTGGAGTAG
- Protein Sequence
- MRLARRSLGAERIATTSTTSATATKLATTSYRLVVAPAGSQRSAGNVVVSSVSGGATVTGNTIVTTGNNSNSSGSGGGALNVTTITTTSNSSQAQSSSGGQSNGTTYKIEMLDDDMQSLATDDEDDDLISSEGSLYDGDLNTLPNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVTPATNQTTSQQLQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAPQQQQQQQHHHHQQQQQQQQQQQHHHQQQHHQQQHLHTTSNNNTTTVHIQAVSQAQPQTIQLTTASGTATATAVPTTAAAVSASQAAQAAAAAAQQQQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLADVNGHDNMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLQTNSDGTVCLAPMQVDNSNTSNNNNTNNNNSSGNNNNSSSGSAAIAAPTSLLGISVINAGAMLGRRGVAAAAATSSAGQQPALTLQAPPGTRFYWAANSGGGAGSSNLNATTSFNLTHNNNNNNSMLTNNNNNNNNNNNNSNSSSSSNNNIKMTLPIVLTAPATSTAQRRQEPNSPRRTAAQKRRKLNNNNNSNSNVDSSSSNSNNNNNKLTLRKKVSDITVPGAATAAAAAEPSTIRCVDSASLTNASGGSAGLQLQLPAIKLEHLE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00573056;
- 90% Identity
- iTF_00532111;
- 80% Identity
- -