Dmel000410.1
Basic Information
- Insect
- Drosophila melanosoma
- Gene Symbol
- Znf48
- Assembly
- GCA_035042045.1
- Location
- JAWNLY010000002.1:2917299-2918975[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 11 0.00025 0.017 15.5 0.6 3 23 13 33 11 33 0.95 2 11 0.0052 0.35 11.3 4.9 1 23 39 62 39 62 0.93 3 11 3.8e-06 0.00026 21.2 1.2 1 23 142 164 142 164 0.99 4 11 0.95 65 4.2 5.3 1 23 170 193 170 193 0.94 5 11 0.00057 0.039 14.3 3.3 1 23 200 223 200 223 0.96 6 11 0.52 35 5.0 1.1 1 10 228 237 228 248 0.83 7 11 0.055 3.8 8.1 4.9 1 23 272 294 272 294 0.97 8 11 2.4e-05 0.0016 18.7 5.8 1 23 307 329 307 329 0.98 9 11 8e-05 0.0054 17.0 2.0 1 23 335 357 335 357 0.97 10 11 8.4e-07 5.7e-05 23.2 0.4 3 23 366 386 364 386 0.96 11 11 0.00037 0.025 14.9 1.2 1 22 392 413 392 416 0.91
Sequence Information
- Coding Sequence
- atgaaagctGTTGCGAAAAGGAATAATGCCATTATTTGTAACACGTGTGGCAAGTGTTTTTTAAAGCCTGCTCTGCTCCGTCGCCATTTAGTTGTGCACAGTCGTGCTAAGTTATTTGCAtgcaacagctgctgcagtcaATTCACACAGAAAAGTTCACTGCAGCGTCACCTACGCACTAAGCATGATGAAGTCAATGACAGCGATTCTTCTCAGGTAGCGCAACAGGCATTGGCTGCCTTAAAAGCTCTGCAAGCAAGTCGTCAAGTTGTTGCTAGCAAAGATGGGCAAAATGCTCTCGAAGAGCAGCAAATAATCAGCTGTCAAGTGGTGCAGCTCAAGGATGCGCTCAATCCAAATGGTGAGCTCCACTTGCTGCCCACGCAGCGCATACAGCGTCATCATCAGCGGGTTAGCTACTTTTATGTATGCGACTACTGCGCCAAGGAGTTTAGCAAAACTTACGATCTCATCCGaCATCGTCGCTCGCACACTAAAGAGATGCCTTATTGCTGCACTTGTTGCTTACTTCGATTTGCCACCCAAGCCAAGTTGAATGAGCATACAAAGAGATTGCATGCCACCTTGCCAAAAAAACACTCATGCAGCAAGTGCAACGCTAGCTACAGTTCAAAAGCAAAGCTGCACAACCATTTAGCTACAGAGCACCCGGATTCGGTTTACAGCTGTACGCAGTGCAAGCGAACATTCCTCAGCAAAGCAGCCTGCGAGGCTCACGAGAAACTTGAGGCAAACCTGCAGGTGGCAAAACTGGTGCCGCTCTTGCCACAAGCAGCAATTTCACAGCGCAGCTACAAATGCATCTACTGTGAGAAACAGTTCAGTCGAAAATTCAACTGCCGCATTCATTTGGTAACCCACCTAAAGCGATTGCTGGTCACGCGTAGGATCCCAAAGCACACTTGTCTGCAGTGTGGCAAGAATTTCAAAAAACTGCACGATCTGAAAAGGCATCTGTTGACGCACTCCAAGCTCAAGTTGCACATTTGTGAAGTGTGCGAGAAGCGTTTTACACTCAAGCTAACATTAAATCGGCACCTGTTGACACACCAGACAAGGCGTAATCCCGTAAATTGTCAGGTGTGTGGCAAATCCTTTGCCTCCAAAACGTCCTTGCAATTACATTTGCGGTTGCACACTGGCGAGCGGCCATTCAAGTGTGAAATTTGCCAAGAAACGTTTCGAACGTCGGGGCACAAGTTGGAGCATGTACGAGGTGAACGACACAGGAATGCCTCCGGTTACAATACGCTTATATCTTATGATGAGGTTTAA
- Protein Sequence
- MKAVAKRNNAIICNTCGKCFLKPALLRRHLVVHSRAKLFACNSCCSQFTQKSSLQRHLRTKHDEVNDSDSSQVAQQALAALKALQASRQVVASKDGQNALEEQQIISCQVVQLKDALNPNGELHLLPTQRIQRHHQRVSYFYVCDYCAKEFSKTYDLIRHRRSHTKEMPYCCTCCLLRFATQAKLNEHTKRLHATLPKKHSCSKCNASYSSKAKLHNHLATEHPDSVYSCTQCKRTFLSKAACEAHEKLEANLQVAKLVPLLPQAAISQRSYKCIYCEKQFSRKFNCRIHLVTHLKRLLVTRRIPKHTCLQCGKNFKKLHDLKRHLLTHSKLKLHICEVCEKRFTLKLTLNRHLLTHQTRRNPVNCQVCGKSFASKTSLQLHLRLHTGERPFKCEICQETFRTSGHKLEHVRGERHRNASGYNTLISYDEV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00528231;
- 90% Identity
- iTF_00535514;
- 80% Identity
- -