Dmel001703.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanosoma
Gene Symbol
H15
Assembly
GCA_035042045.1
Location
JAWNLY010000043.1:5538417-5554824[+]

Transcription Factor Domain

TF Family
T-box
Domain
T-box domain
PFAM
PF00907
TF Group
Unclassified Structure
Description
The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.7 4.5e+03 -2.8 1.8 93 138 59 77 18 97 0.48
2 3 10 1.7e+04 -6.4 5.6 69 90 192 213 172 242 0.43
3 3 7.3e-73 1.2e-69 233.7 0.0 1 182 313 506 313 506 0.96

Sequence Information

Coding Sequence
atgctgttaaGCAATCAGCCGGCAAATGCACAGCCGCCGTCGCCGACAGCGCCACAAAGTTTCAAAGCcaagttgcagcaacaaattgcaactgcagcagtagctgccgcagcagctgccgcaacaacaattgccaataataataacaacaacatcaacaacaatcatcagcaacagcagcagcagcaacatcagctaCATCAGCTACAACATCTAAataatcatcataatcatcatcatcatcatcatcagcataaCATTTCCTTTGCCACGGATTTCTCAATTGCCGCAATAATGGCACGCGGCGGAAACGGGGCAAGTTTGAGTCGCGAGCCATCCGAAAGGAGTCTGAGTCCGTTGTCTGTTGAACGCTACTCGACGCAGGATGCGGACGATGATGTTGACGTTGATGTGGTTGACTGCAGCGACAGCGAAAcgccaacggcaacagcagcaacagcaacagccgcagcagcagcagcggcggcggcggcagcagcagcagcagctgcagcacagcAACAAGCGCGGCAGGCATTGCGTgttgcacagcaacaacaacaactgcaacagcaacaacaacaacaacaacacagacagcagcagcagcaatcacatCAGCAACATGCAACGCCAAacaagcagcgacaacaacacaatcatcacaacagcaacagcaacaacaacagcaacaacaacaatagcaatcaCCACAAATCGAGCAGTCAGCGAgcgagtgggcgtggcacgaGTGCATCAGCTGCAACTGGCGCTGGCAGCACGCCCtcaccgccgccaccaccgcccGCCGCACCGCCCCCACGTGCCGCAAACAGCCCCAGCGAAGACGAGCGCCTGTCTCCCGAGGAGCCCGCGCAGCAGCCGACGCCCAAAATTCTTGGCACTTGCAACTGCGATGATCTTTCGCCGGTGCAATGCCATCTGGAGACCAAAGAGCTCTGGGATAAATTCCACGAGCTCGGCACCGAAATGATCATCACCAAAACGGGCAGGCGCATGTTCCCCACGGTGCGTGTGAGTTTCTCGGGTCCGTTGCGGCAAATTCAGCCACCGGATCGTTATGCCGTATTGGTGGACATTGTGCCGTTAGATTCGCGTCGCTATCGCTATGCATATCATCGCAGCTCATGGCTGGTGGCCGGCAAAGCGGATCCACCGCCACCCGCACGCATTTACGCCCATCCCGACAGCCCCATCAGCCCGGAGGCGTTGCGCAAACAAGTCGTCTCCTTTGAGAAGGTGAAGCTGACAAACAACGAAATGGATAAGAGCGGACAGGTCGTGCTGAATTCTATGCATCGCTATCAGCCAAGAATTCATTTGGTGCGTCTGAGCCATGGTCAGAGCATACCCGGCAATCCCAAGGAGCTGCAGGATATGGATCATAAAACGTTCGTTTTCCCAGAGACCATATTCACGGCCGTGACGGCCTATCAGAATCAATTgattacaaaattgaaaatcgatTCAAATCCGTTCGCAAAAGGATTTCGCGATTCGTCTCGTCTGACTGATTTTGATagAGATCCGATGGATTCGTTTTTCTTTGATCAGCACATGCGTGCGGCACCGTTGCGCTTCTTTCCGGATCCGCTGATGGGGCAACTGACGCCGCAGGAGGCGGACGCCGCCTCGTTGGCGCTGCTGGAGAAGGCGCGTCAGCATTTGCAGATGTTTGGCCGTTCGCCGTATACGgaaatgttgctgccacacttGTATCAGCGTGCCGCACCACCCGCGCCACCCTCAGCGCTGGGCGCCTTTCAGCTGggcatgtggcagcaacagtggccACAGTTGACCGCTGGCTTCTTGGCCAGCGCCAATCAGCAGGCAGCGtttgcagcggcagcagcagcagctgcgggcGCCAGTCGAACCCCTCCACCCACATCGCTTGGAGCCGCAGTCACAGCACCGCCCGcacctgccacgcccacatctTCGTGCGGCTCAGCATCGCCCGATTTGCGCATCAAAAGCCAACTGGGCCATTATCCGCAACGTTTCAGTCCCTACCAAGTGCCGCAGCATCCACAATCGTCGCCGGCAACATCCTCGCGAGCGGACAGTCCCTAA
Protein Sequence
MLLSNQPANAQPPSPTAPQSFKAKLQQQIATAAVAAAAAAATTIANNNNNNINNNHQQQQQQQHQLHQLQHLNNHHNHHHHHHQHNISFATDFSIAAIMARGGNGASLSREPSERSLSPLSVERYSTQDADDDVDVDVVDCSDSETPTATAATATAAAAAAAAAAAAAAAAAQQQARQALRVAQQQQQLQQQQQQQQHRQQQQQSHQQHATPNKQRQQHNHHNSNSNNNSNNNNSNHHKSSSQRASGRGTSASAATGAGSTPSPPPPPPAAPPPRAANSPSEDERLSPEEPAQQPTPKILGTCNCDDLSPVQCHLETKELWDKFHELGTEMIITKTGRRMFPTVRVSFSGPLRQIQPPDRYAVLVDIVPLDSRRYRYAYHRSSWLVAGKADPPPPARIYAHPDSPISPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGNPKELQDMDHKTFVFPETIFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDRDPMDSFFFDQHMRAAPLRFFPDPLMGQLTPQEADAASLALLEKARQHLQMFGRSPYTEMLLPHLYQRAAPPAPPSALGAFQLGMWQQQWPQLTAGFLASANQQAAFAAAAAAAAGASRTPPPTSLGAAVTAPPAPATPTSSCGSASPDLRIKSQLGHYPQRFSPYQVPQHPQSSPATSSRADSP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00501814;
90% Identity
iTF_00570405;
80% Identity
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