Basic Information

Transcription Factor Domain

TF Family: T-box
Domain: T-box domain
PFAM: PF00907
TF Group: Unclassified Structure
Description: The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.2 5.1e+03 -3.0 2.6 94 133 25 64 5 88 0.51

2 3 0.75 1.2e+03 -1.0 1.3 73 98 178 203 145 229 0.52

3 3 2.2e-10 3.5e-07 30.1 0.1 1 26 287 312 287 312 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.2	5.1e+03	-3.0	2.6	94	133	25	64	5	88	0.51
2	3	0.75	1.2e+03	-1.0	1.3	73	98	178	203	145	229	0.52
3	3	2.2e-10	3.5e-07	30.1	0.1	1	26	287	312	287	312	0.96

Coding Sequence: ATGCTTTTGAGCAATCAGCCGGCAAACACGAAACCCCAGCAGCAAACGCAGCCTTCGTCGCCGTCGCAGAACTTCAAGTCGAAGCTGCAACAACAAATCGCGAGCATAGCCAACGGGGGCAGttctcatcatcatcagcagcagcatcagagCCACCaccagcatcatcatcatcatcatccgctGGACAATCATAATCATCAGGCGCAGCATCAGCATAACATTTCCTTCGCCACGGATTTCTCAATTGCCGCGATTATGGCGCGCGGCGGAAACGCCCCGAGCAGCCGGGAACCATCGGAGCGGAGTCTGAGCCCCGCATCTGTGGAGCGCTATTCTGGCCAGGATGCGGACGATGATGTGGATGTTGACGTTGATGTGGTCGACTGCAGTGACTCGGAAACGCCGACGGCAAcatcagcagcggcagcagcaactgcaaatGCCGCAGCAGTggccgcagcagctgcagcagcattgCAGGCGCAGCAGAAAGCGCATCAGGCGTTGCGTGTTGCGCAGcaacaaaggcagcagcagacaCATCACCAGGCAACGGCAAACAAGCAACAACGCCAACATCACAATCATcataccagcagcagcagcagcagcaacaatggcaacatcagcaactccagcaacagcaactcgAGCAGCCACAATAACAAATCAAGTGGGCATCGAGGGCGTTCAGCTGCCGCAGTTGGAGGCGCTGCCACGCCCTCGCCGCCACCGCCCCCGCCCTCGCAGAGTCCCGAGGAAAACGAACGCCTGTCGCCAGAGGAATCGCCAGCGCAGcAGCCCACGCCCAAGATAGTGGGCTCGTGCAACTGCGACGATCTCACGCCCGTTCAGTGCCACCTGGAGACCAAGGAGCTGTGGGATAAGTTCCATGAATTGGGCACTGAAATGATCATTACCAAATCGGGCAGGTGA
Protein Sequence: MLLSNQPANTKPQQQTQPSSPSQNFKSKLQQQIASIANGGSSHHHQQQHQSHHQHHHHHHPLDNHNHQAQHQHNISFATDFSIAAIMARGGNAPSSREPSERSLSPASVERYSGQDADDDVDVDVDVVDCSDSETPTATSAAAAATANAAAVAAAAAAALQAQQKAHQALRVAQQQRQQQTHHQATANKQQRQHHNHHTSSSSSSNNGNISNSSNSNSSSHNNKSSGHRGRSAAAVGGAATPSPPPPPPSQSPEENERLSPEESPAQQPTPKIVGSCNCDDLTPVQCHLETKELWDKFHELGTEMIITKSGR

Sequence clustering based on sequence similarity using MMseqs2