Basic Information

Insect: Drosophila mayaguana
Gene Symbol: Runx1
Assembly: GCA_037075325.1
Location: JBAMCG010000120.1:660999-681316[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5 1.8e+04 -13.1 10.2 59 75 26 43 19 49 0.52

2 3 3e-73 1.1e-69 232.0 0.0 3 129 100 226 98 226 0.98

3 3 2.9 1.1e+04 -4.0 0.0 69 91 598 621 594 624 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5	1.8e+04	-13.1	10.2	59	75	26	43	19	49	0.52
2	3	3e-73	1.1e-69	232.0	0.0	3	129	100	226	98	226	0.98
3	3	2.9	1.1e+04	-4.0	0.0	69	91	598	621	594	624	0.73

Sequence Information

Coding Sequence: atgcatttgacaaCGACGAGCAGTAATTCGACGGCATCCAATGCCaattccaacaacaacaccaactccaacaacaataacaacaacaacacagccaacaacaacaacaacaacacagccagcagtaataacaacaacaacagcaacacaaatggctccaacaacaacaataacaacaacaacagctcgagcagcaacaacaacacagagCAGAACACACCGCCCACACCCGCCCAGCTGCTGAACGAGGCCTACACAAAAATGACCTCGGACATCTTGGCTGAGCGCACCCTGGGCGACTTCCTCACCGAGCATCCCGGCGAGCTGATAAGAACCAGTAGTCCGCTCTTCGTCTGCACCGTCCTGCCGCCGCACTGGCGCTCCAACAAGACGCTGCCGGTGGCCTTCAAGGTGGTCTCCCTGGGCGACATCATGGACGGCACCATGGTCACGGTGCGCGCCGGCAACGACGAGAACTACTGCGCCGAGCTGCGCAACTGCACCGCCGTCATGAAGAACCAGGTGGCCAAGTTCAACGATCTGCGCTTCGTGGGCCGCAGCGGTCGAGGCAAGAGCTTCACACTAACCATCACCGTGTCAACGAATCCACCCCACATAGCCACCTACAACAAGGCGATCAAAGTGACTGTCGACGGGCCACGCGAGCCACGCTCCAAAACCAggcaacaacaacaattccacTTTGCATTTGGCCAGCGACCGTTCCACTTCTCCACGGATCCACTGTCCGGCTTCCGCATGCCGCCCATCGGCAACTGTCAGAGTGCCAGCAATACGCATTGGGGCTATGGATCGGCGGCGTCTGCCTACTCACCGTACTTGGCCAGCAGTGGACTCTCCTCCTGCACCACGCCCACATCAGCACAGTTCAACAATCCGGCATTGGGCTTCACCTGCTCGTCGAACGATCAGACCAACAACCAGGACTTTAGTGGCGCCACCAATCGCGACTGTGTCCCAATGCTGCCCGACTCGACGGCCAGTGACTTGGACCAGCATCTCAGCAGCCTGGTCGGCTCGACCAGCGGCCAGATGTCGCACCATAGCCTGCTGGGCGCCAGCGGACAGACGTCCATAACATCGACGGTGAACGGGGCGGGCGCCGGCAGCGGCGCCACCGCTGGCAGTGCAACGGgcgccggcggcggcggtggtggggCCAACTCGATTCTGGTGCCGCGATACCACACCAATGCCAGCAACGAGTACAATGTGCATTCCAGCCAGAATGGGCCGCGCAGCCTGAGCGACAGCTCGCAGGCCGAGTCGCCGGTGCAGGAGGACCTGCTGTCCACCAATACACCCAATCTGGGCAGCGGCACTGGCGCCGGGGCGAGCAACGGTGGTGCCGCCAACGGTGCGGCGAGTGCagctggcgctggcagcggcgGAGCGGCAGGAGCATCGGCCGGCGCCGTCAATCCCGCCATGCTGGGCGCCAATCAGAACTTTCCGGGCATTGTGAACCAGGCCCAGCATGCCTCCGCCTCGGCCTATGGCGGCGGCGTCGGTGTGggcgtcggcgtcggtgtgggcgtgggcgtgggcggggGCCATGGCAGCGGCGCTGGGGCCACGGCCGCCGGCTGCAATGGCTCGCTGTACCCGGTGCTGCCGGCCAGCCTGCTCTACTCGCAGCTGTACACTGCCGCCAATCAGTCGGCGCACGGCTTCCACTCGCACACGCTGCCGGCGCACGCGTCGCCCAACTCGTCCGTGCACGGCGAGCTGCAGAGCGTCATGGATCACATCAGCAATGTGGGCGTacggcagcagcacaacaTCATGACcggcgggggcgtggcgcaTCCCGGCGACCTCACGCTGATCGGCAACTGCGGCGCGTCGGTGCGCAACATCGAGGATGGCAACACCAATCGGCAGGTGGCCGCGCTCGCTGCCCATCGCGGCCACCACAACCCAACTGACAATGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence: MHLTTTSSNSTASNANSNNNTNSNNNNNNNTANNNNNNTASSNNNNNSNTNGSNNNNNNNNSSSSNNNTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTRQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQTNNQDFSGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGASGQTSITSTVNGAGAGSGATAGSATGAGGGGGGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGTGAGASNGGAANGAASAAGAGSGGAAGASAGAVNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGVGVGVGVGGGHGSGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579764;
90% Identity: iTF_00509592;
80% Identity: -