Basic Information

Insect: Drosophila mauritiana
Gene Symbol: zfh1
Assembly: GCA_004382145.1
Location: NC:27571434-27594344[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0011 0.067 13.3 1.7 2 23 75 97 74 97 0.95

2 9 0.0012 0.075 13.2 0.2 1 23 286 308 286 308 0.96

3 9 9e-05 0.0055 16.7 1.7 2 23 322 343 321 343 0.97

4 9 4.4e-06 0.00027 20.9 6.3 1 23 352 374 352 374 0.99

5 9 0.00026 0.016 15.3 1.2 3 21 382 400 380 401 0.94

6 9 0.006 0.37 11.0 0.7 2 21 625 644 624 645 0.92

7 9 8.6e-06 0.00053 19.9 0.5 1 23 963 985 963 985 0.95

8 9 4.3e-05 0.0027 17.7 7.4 1 23 991 1013 991 1013 0.98

9 9 0.0022 0.13 12.4 4.3 1 21 1019 1039 1019 1040 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0011	0.067	13.3	1.7	2	23	75	97	74	97	0.95
2	9	0.0012	0.075	13.2	0.2	1	23	286	308	286	308	0.96
3	9	9e-05	0.0055	16.7	1.7	2	23	322	343	321	343	0.97
4	9	4.4e-06	0.00027	20.9	6.3	1	23	352	374	352	374	0.99
5	9	0.00026	0.016	15.3	1.2	3	21	382	400	380	401	0.94
6	9	0.006	0.37	11.0	0.7	2	21	625	644	624	645	0.92
7	9	8.6e-06	0.00053	19.9	0.5	1	23	963	985	963	985	0.95
8	9	4.3e-05	0.0027	17.7	7.4	1	23	991	1013	991	1013	0.98
9	9	0.0022	0.13	12.4	4.3	1	21	1019	1039	1019	1040	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTCTGGCGCCGTCGTCTTCACGTTTCGGCCAAGAGGATACCATCATTCAGCAGAGCATGCCCTCCACCTCCCCCTTCGCCATGCAGTTTCCCTCGCTGGCCTCCACTTTGCTCCACCACAACCAGTCGCCGAAGCACAGCAATCCCGGATCCAGCGGGATCCAGGATGCCCACCCCAACCAGCCAGGTGCCGCTGCAGATGCCTTCCTGGTCAAGTGCACCCAGTGCCACAAGCGATTCACCGAGTATCAGTCCCTCAGCGAGCACATTGCCAGCGAGCATCCACACGACAAGCTGAACTGCGGAGCTGCCCAGCCGGAGAGCGATGCCGAGGACGAGCAGAGCAACAtgagcggcagcagcaggcggTACGCCAAGTCGCCGCtggccagcaacaacaacagcagcaccgccaacgccaacaacaacagcaccagCAGCCAGTCCatgaacaacaacagcgagcTGGCCAAGAACCACAACAGCGCCAACAAAATGTCGCCCATGTGCTCACCTGGCTCCCTCACCCCCGGCGACCTCTTCGCCCAGCTCCAGCACCCGCCGCCCCAGCTGCCGCCCCACCTGCACGCCCAGTTCatggccgccgccgcctccctGGCCATGCAGTCCGCCCGCACCGCCAGCTCGCCcagccaacagcagcagcaccagcagcagcaccaccaccagcagcagcagcatcagatGGCCATGCAGCAACTGCTGCCGCCGCAGCTGcccggcagcaacagcagcgtgGGCAGCAACTCCGCCTACGACCTGGACCTCAGCGCCCCGCGCTCCACCTCCAGTCCGGGCTCCACCACCGGCGACCTGAGTGGCGCCTATCCCTGCATGCAGTGCACCGCCTCCTTCGCCAGCCGCGAGCAACTCGAGCAGCACGAGCAGCTCCACTCGCCCTGCGGACCGGCGGCGGTCAGCAATGTCTCCCAGACATGCCGCATCTGCCACAAGGCCTTCGCGAACGTGTACCGCCTGCAGAGGCACATGATCAGCCACGACGAGAGTGCGCTGCTGCGGAAGTTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTCAAGGAGCACGTGAGGATCCATTCCGGCGAGAAGCCCTTCGGATGCGACAACTGCGGCAAGCGGTTCTCGCACTCGGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAACCGCGCTCTGCTGAAGCGCCTGGAGAAGAGCCCGGGTTCCACATCCTCCGGATCCCGGCGATCGCCCTCCGATCACGGTAAGGGAAAGCTGCCGGAGCAGCCGTCGCTGCCGGGACTACCCCATCCGATGAGCTACTTCGCCAGCGATGCGCAGGTGCAAGGTGGAAGTGCGGCACCCGCGCCCTTCCCGCCATTCCATCCGAACTACATGAACGCGGCCCTGCTGGCCTTTCCCCACAACTTTATGGCGGCTGCAGCTGGCCTGGATCCTCGGGTGCATCCCTACAGCATCCAGAGGCTGCTGCAACTTTCGGCCGCCGGGCAGCAGCAGAGGGAGGAGGAGCGAgaggagcagcagaagcagcagcatgaggaggaggagaccCCCGATGAGTCCAAGCTGGTGATGGATATCGAGGAGCCGGAGACCAAGGAGAGGGCACCCACGCCAGAGGCCACCGAAGCAGCCACTCCCATTAAGCGGGAAGAGAGCAGGGAAGCCTCTCCAGCTCCAGAGAGCTACCGTTCCTCCTCGCAAGCAATcaagcaggagcaggagcccCTGAACGTAGCAGAGGAACGTCAAACTCCTGTGCAAGAACACGCCCCAGTGGAGCATGCCGCTGATCTGCGCTGCAGTCGCTGCTCCAAGCAGTTCAATCATCCCACTGAGCTGGTGCAGCACGAGAAGGTGCTTTGTGGCCTGATCaaggaggagctggagcagcacTTCCAACAGCAACAGGCCACGTCCTTCGTCTTGGCCTCCGCCAGCGAAGAGGATGAGGAAGACGAGgagatggatgtggaggagGAGCCCCGGCAGGAGAGTGGCGAGCGGAAAGTCCGCGTGCGAACGGCCATCaacgaggagcagcagcagcagttgaaGCAGCACTACTCCCTGAACGCTCGACCCAGTAGGGATGAGTTCCGAATGATAGCAGCCCGTCTGCAGCTGGATCCCCGGGTGGTTCAAGTGTGGTTCCAGAACAACCGCTCCAGGGAGCGCAAAATGCAGAGTTTCCAGAACAACCAGGCGGCAGGCGCAGCACCGTCAGTGCCCAATGACTCCCAGACATCTCTAACCCGGGAGGATCAACCGCTGGACTTGTCTGTGAAGAGAGATCCCCTCACGCCGAAGAGTGAGAGCTCGCCTCCGTACATAGCTCCACCGTCGGGAGAAGCCCTCAACCCCGAAGCAATCAATCTCAGCAGGAAGTTCTCCACATCCGCATCGATGTCACCGGCCTCGATTTCACCGTCATCCGCGGCAGCCCTCTACTTTGGAGCTGCCCCGCCGCCTTCGCCCCCAAATAGCCAGCTGGAGTCCACTCCTCGGAGTGGCCAGGCCTTTCCGGGACTACCTCCCTACATGCTGCCCATGTCGCTGCCCATGGAGGCGCTGTTTAAGATGCGCCCGGGCGGAGACTTCGCTTCCAACCATGCCTTGATGAACAGTATTAAGCTGCCCGACTACCGGGGCACCAGCTTGAGTCCCGGCGGATCGGAGAAGCGTTCGTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGAGTTCGGCGCCGGCGTCCTGATGCCACCGAAACCGCGGAGGGGCAAGGCGGAGACCCACGGACACGCTGGCGATCCCGATCTGCCCTACGTGTGCGATCAGTGCGACAAGGCCTTCGCCAAGCAGAGTTCGCTGGCGCGACACAAATACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTCACGGAGCACAAGCGTCTGCACAGCGGCGAGAAGCCCTTCCAGTGCTCCAAGTGCCTGAAGCGCTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGGTATTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDTIIQQSMPSTSPFAMQFPSLASTLLHHNQSPKHSNPGSSGIQDAHPNQPGAAADAFLVKCTQCHKRFTEYQSLSEHIASEHPHDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQQHQQQHHHQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFASREQLEQHEQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSTSSGSRRSPSDHGKGKLPEQPSLPGLPHPMSYFASDAQVQGGSAAPAPFPPFHPNYMNAALLAFPHNFMAAAAGLDPRVHPYSIQRLLQLSAAGQQQREEEREEQQKQQHEEEETPDESKLVMDIEEPETKERAPTPEATEAATPIKREESREASPAPESYRSSSQAIKQEQEPLNVAEERQTPVQEHAPVEHAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQQQQATSFVLASASEEDEEDEEMDVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQAAGAAPSVPNDSQTSLTREDQPLDLSVKRDPLTPKSESSPPYIAPPSGEALNPEAINLSRKFSTSASMSPASISPSSAAALYFGAAPPPSPPNSQLESTPRSGQAFPGLPPYMLPMSLPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00588330;
90% Identity: iTF_00596880;
80% Identity: iTF_00539563;