Basic Information

Insect: Drosophila malerkotliana
Gene Symbol: ZEB2
Assembly: GCA_018153235.1
Location: JAECXV010000198.1:7950453-7952924[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 2.6 1.9e+02 2.7 2.3 3 23 287 309 285 309 0.91

2 10 1.1 80 3.8 1.5 3 21 451 469 449 473 0.91

3 10 0.067 4.9 7.7 1.9 2 23 495 517 494 517 0.94

4 10 1.1 79 3.8 3.0 1 23 534 557 534 558 0.94

5 10 0.41 30 5.2 0.2 1 21 562 582 562 586 0.90

6 10 0.0009 0.066 13.5 0.2 2 23 631 653 630 653 0.92

7 10 0.012 0.91 9.9 0.2 1 21 658 678 658 679 0.94

8 10 0.0006 0.044 14.1 4.3 2 23 737 757 736 757 0.97

9 10 3.6e-06 0.00026 21.1 1.1 1 23 763 786 763 786 0.97

10 10 1.5 1.1e+02 3.4 0.2 1 9 811 819 811 823 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	2.6	1.9e+02	2.7	2.3	3	23	287	309	285	309	0.91
2	10	1.1	80	3.8	1.5	3	21	451	469	449	473	0.91
3	10	0.067	4.9	7.7	1.9	2	23	495	517	494	517	0.94
4	10	1.1	79	3.8	3.0	1	23	534	557	534	558	0.94
5	10	0.41	30	5.2	0.2	1	21	562	582	562	586	0.90
6	10	0.0009	0.066	13.5	0.2	2	23	631	653	630	653	0.92
7	10	0.012	0.91	9.9	0.2	1	21	658	678	658	679	0.94
8	10	0.0006	0.044	14.1	4.3	2	23	737	757	736	757	0.97
9	10	3.6e-06	0.00026	21.1	1.1	1	23	763	786	763	786	0.97
10	10	1.5	1.1e+02	3.4	0.2	1	9	811	819	811	823	0.85

Sequence Information

Coding Sequence: ATGAATCCAGACGACTTGGAAGACACCCATTTGTGCATAAAATGCAATGCCACAATTCTTGGATTGGAAAAATATATTGAACATCGAAAGCAAAACTGCTTGGTTGCCGAAAAGAGGGCAGTGACTACCTCAGCGGAAGGACCTGTCACCACATCAACTCCCACCCAAGTTTCTGCATCAATTATCAGTCGCAGCAACTTGGATCACAGTTACGATGGCTTCCATTTCACGGAACCGGAAGCTCCCAGCAGCTATCTGCGGAAAACAGCAGCCAGTCATGGCGGAAAGACCTCAAAGTCCCTGACCGAAGCCTACGATCTGACCTATGAACTGGGAGCTGATCTGTTCTTTTCTTCGCTGCAACTGCAGAGTGTTTCTACGGGCGGGAAGACTGGGTCAGTGGCACGACAGGAGAGGCCAAAGGAGGATTCATGGCCAGCACCCGGAAGAGATCCACTGCTGAAAGCTGTGCGGGAGCACGAGGATACTGTTTTCAAGCCTCTAAATTTCGATCACGACTACCCGGAGGCCAGCGAGGAGGAGGATGAGGAGGACGAGCCGGATGATTTCGACCCGGAGCCGGAGGAAGACGACGAAGAGTACGACGTGAGGCGTCACTCGCCACCGACAGTGCCCGCCACTCATACAGGCGGTAAGTGGAAGCCCGAGCACCGCCCTCAGCTCCGGCATCCGCATATCGAACGGATCTCGCCCAGCTGGGATGAGCCACCCGAGGAGGCGTTCATCCACCCGCCAGAGGACCACACCAAGGGCAAGTGGGTGCCCGGCAGCAAGCAGTTGGAGTACCGCGAAAACATAGACCTCACCAAGCTGGAGCAGCCGGGGGCCAGTTATTGGTGCAACATTTGCTGCAGGCGCCTGAAGAGTCGCCTGAACTACGAACAACATTTGAGAAGTGGCTACCACTTGAAGAGGGCTGAGGCCGAGTGCCAGTTGGAACAGGCCACCTTGGGCAGGGAGCTCAGCCTGAGCAAAGAATTCGCCGTGGAGGTCAAGGACAAGGAGAAGGATCCACCACAACCAGAAAAGAGAAAAAGGCGAGCCAACTATCTGCGCTGCGATCTTTGCCGGCACCCAATGGCCCGCCACCTGATGGGAAAACACCTGATCTCCCACTACCATTACCGACGGCTGCAGCAGCAACAAAATCAAGGTAGGAGACAGGCGTCCCTGCAGGACATCCTTAGCCACATGGGCAGCATAGTGAGGCAGTCTCCGTTTCAATGCCTGCCCTGCAGGTTCTATGCCAACACGGAGGAGGCTTTCCTTGACCACTGGCAATCCCAGACCCATTCGGCTCTCACCCAGAAGCTAGGTGGCTCTTTTTGGTGTAGCTACTGCCAGTTTGAGTGCCCCACCAACGATGAGATGTGGATGCATTTGCTCCATGCCTCCCACAAGGAGGTGGTCATGGCGTTGAATCGCTCGGTTCCCATTTACATAGCCCAGAGAAGACATCTCCAGTGCTCCAGTTGTGGGCTGAGCTTCCTATACAACTTCCAACTTCGCCACCACTTTGCCACCGACCATCCTGGCCAGACTGCAACTGGAAGTGCTGGGGATGACTACCAGTGTAGGTTCCGATGTGGCCTGTGTGGCATGCCACAAAAATCTCGGCTGGCTCTGCAACGCCACGAAAAGCACAAACATCACTTGGCCAGGTATTACTGTGCCATTTGTCGACTGGACTTTGAGACGCCTCTGGAGGCTCGACGTCATCGGAGCTTGATGCAACACAAGCTGAAGGCCAGACCGAAAGGGACGAAAGCCCACCCAGATAAAGAAATTGAAAGTATGCTGCGGGAAGTTCTGGATGACCCCTCGGATCCAAATGCTAATCCCTCAAAGAAAACCAAGATTGTTCCCAAAAAATGCGCCAACTGCGAGGAGGTCTTTGATTCTCCTCAGAATTTATCCCGCCATCGAGCCGAGATGCATCCTGCCGACAATCATGTCTGCCTGAGCTGTGGCCAAAGCTTTCAATCCGCTCAAGCTTTGGGCAGGCACACCCGGAGCTGCCAGCCCCAGGCCAGCTCATCCTCCTCTGCATCCCCAGCACCCGAAAATCCCAAGAGCACCAACTACTCCTGCGATCAAAGCCAGTTTCGTTCCCAATTCGAGTCTGATCTTATTTACCATCGTCTCTTCCACACCCGTACAGGGAGTATTGGCAAGAACGAACTACTCCAGTGTCCTCTGTGTCCTAAGCACTTTAAAAAGCATTCCCTCAGAGCTCATCTCCGAAATCACACCGATGAGAGGCTCTTCGAGTGTCCAGAGTGCAAGCTAAAGTTTGCCAGAAGACACAACTTGAAGAATCATGTGGCCACAGTTCACGGAAAGAAAGAGGATCTGGAGGTAACTAAATTGGCCAAGAAAAAAGAGACTAGCAAGCAAAACAAAGCCAAATATCAATGTGGAACCTGTGGAAAAATTTTAGCCAAAAAGTAA
Protein Sequence: MNPDDLEDTHLCIKCNATILGLEKYIEHRKQNCLVAEKRAVTTSAEGPVTTSTPTQVSASIISRSNLDHSYDGFHFTEPEAPSSYLRKTAASHGGKTSKSLTEAYDLTYELGADLFFSSLQLQSVSTGGKTGSVARQERPKEDSWPAPGRDPLLKAVREHEDTVFKPLNFDHDYPEASEEEDEEDEPDDFDPEPEEDDEEYDVRRHSPPTVPATHTGGKWKPEHRPQLRHPHIERISPSWDEPPEEAFIHPPEDHTKGKWVPGSKQLEYRENIDLTKLEQPGASYWCNICCRRLKSRLNYEQHLRSGYHLKRAEAECQLEQATLGRELSLSKEFAVEVKDKEKDPPQPEKRKRRANYLRCDLCRHPMARHLMGKHLISHYHYRRLQQQQNQGRRQASLQDILSHMGSIVRQSPFQCLPCRFYANTEEAFLDHWQSQTHSALTQKLGGSFWCSYCQFECPTNDEMWMHLLHASHKEVVMALNRSVPIYIAQRRHLQCSSCGLSFLYNFQLRHHFATDHPGQTATGSAGDDYQCRFRCGLCGMPQKSRLALQRHEKHKHHLARYYCAICRLDFETPLEARRHRSLMQHKLKARPKGTKAHPDKEIESMLREVLDDPSDPNANPSKKTKIVPKKCANCEEVFDSPQNLSRHRAEMHPADNHVCLSCGQSFQSAQALGRHTRSCQPQASSSSSASPAPENPKSTNYSCDQSQFRSQFESDLIYHRLFHTRTGSIGKNELLQCPLCPKHFKKHSLRAHLRNHTDERLFECPECKLKFARRHNLKNHVATVHGKKEDLEVTKLAKKKETSKQNKAKYQCGTCGKILAKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00550565;
90% Identity: iTF_00566405;
80% Identity: -