Dmal000522.1
Basic Information
- Insect
- Drosophila malerkotliana
- Gene Symbol
- ZEB2
- Assembly
- GCA_018153235.1
- Location
- JAECXV010000036.1:1561610-1562758[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 6 0.00018 0.013 15.7 0.2 1 21 188 208 188 209 0.97 2 6 7.2e-06 0.00052 20.1 0.8 2 23 223 244 223 244 0.98 3 6 6.6e-05 0.0048 17.1 1.9 1 23 250 272 250 272 0.98 4 6 6.3 4.6e+02 1.4 0.8 1 11 299 309 299 311 0.91 5 6 0.58 42 4.7 0.1 1 21 321 341 321 342 0.92 6 6 0.001 0.074 13.4 0.5 1 20 349 368 349 368 0.96
Sequence Information
- Coding Sequence
- ATGAATGCCAAACGTGTAAAATACTCGACGGCGATCAAGGAGGAGATAGTGCCTGTCATCTTGCATGAGGATCCGGAAGAGGTCGAGGAGGTGGAGGCCCACGACGAGAGCGGCGACGGAGATGGTGGCGAAACTCAATACACCTATGCCTACACCACCAACGAGGATGATGATACCGAAACGGCTGTGGTGACTCTCAGCGACCGGGATCACGAGGCCCTGGCCAACGCCCAGGAGGTGATTATTGATGAGAACGGCCATCCCGTATCTTTGCAACATTATGTGGAGAACAGCACCGTCGAGGAGGTTGAGACTATCGAACAGGGCGACGGCACGCACACAATTCTGCACATCGTACCGAATAGCATGCACGATGATCAGGACGAAGATGACGTCGAGGACGAGGAAGTTGATGACGGCGAGGAGCTGGATGAGGACGAAATGGTCACCGTAGAGCATGAAGTTGAGGGCGAGGAGGACGACGACGATGTTGGATCTCTCGTCTTCGAGGGCACCATTGATCACGGCGCCGAACAGGAGATGCATGGCCGTAACAAGACCTTCTATTGCCCCAACTGTGGCAACTGCTACAGTGCTGCCGGTTCGCTCAAGCTTCATATGCGCGCCTGCTTGCGCCAGCGTAACGAGGTCTCTACAGAGGACCGCAAGTGCAAGGTGTGCAGCAAGGTCTTCAACTCGGTGGCCTATCTGAAGGAGCACATGATGCGCCATACCGGCGAGCAGCCATACCGCTGCACCCGCTGCTATCGCAAGTTCGTTGACGAGTCCAAATACACCGCTCACATGGAGTCGCACAAGCACCAGGATAAGCTCGAGGCCGAGGCCGTCGCATTGGCTGCTCAGCACGGCGGCAAGAAGGTGGTCGTCAAGGAGTTCAACTGCTCCTTCTGCTCCCAGAACTTCACTGTCGTCTTTGATGTTGGACAGGTTAAGCGCCGCTATGCCTGCGACGCTTGCCGCGACAAGTACTCCAACGCCGAGGCACTGCGCCAGCACAAGCAGCAGGTGGAGGAGAAGCGTGAGTTTAGCTGCGAGCGCTGCGGCCGCAAGTTTGTGTTCGAGGGCTTCCTCCAGCGCCATCTGCCGACCTGCGATGGCAGCATTAAGCGTCGTCGGGATATGAAGTAG
- Protein Sequence
- MNAKRVKYSTAIKEEIVPVILHEDPEEVEEVEAHDESGDGDGGETQYTYAYTTNEDDDTETAVVTLSDRDHEALANAQEVIIDENGHPVSLQHYVENSTVEEVETIEQGDGTHTILHIVPNSMHDDQDEDDVEDEEVDDGEELDEDEMVTVEHEVEGEEDDDDVGSLVFEGTIDHGAEQEMHGRNKTFYCPNCGNCYSAAGSLKLHMRACLRQRNEVSTEDRKCKVCSKVFNSVAYLKEHMMRHTGEQPYRCTRCYRKFVDESKYTAHMESHKHQDKLEAEAVALAAQHGGKKVVVKEFNCSFCSQNFTVVFDVGQVKRRYACDACRDKYSNAEALRQHKQQVEEKREFSCERCGRKFVFEGFLQRHLPTCDGSIKRRRDMK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00510850;
- 90% Identity
- iTF_00488294;
- 80% Identity
- iTF_00488294;