Basic Information

Insect: Drosophila malerkotliana
Gene Symbol: zfh1
Assembly: GCA_018153235.1
Location: JAECXV010000008.1:19325834-19327855[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.14 10 6.6 0.2 1 21 321 341 321 342 0.95

2 10 9.9e-07 7.2e-05 22.9 0.3 1 23 350 372 350 372 0.99

3 10 0.00021 0.016 15.5 0.4 1 23 375 398 375 398 0.93

4 10 6e-07 4.4e-05 23.5 0.8 2 23 405 426 404 426 0.98

5 10 2.8e-08 2.1e-06 27.7 1.0 1 23 432 454 432 454 0.98

6 10 4.2e-06 0.00031 20.9 0.8 1 23 460 482 460 482 0.99

7 10 0.001 0.074 13.4 3.1 3 23 490 510 488 510 0.98

8 10 0.00086 0.063 13.6 0.3 1 23 516 538 516 538 0.98

9 10 8e-05 0.0058 16.9 3.7 1 23 544 566 544 566 0.99

10 10 0.00092 0.068 13.5 0.1 1 23 572 594 572 594 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.14	10	6.6	0.2	1	21	321	341	321	342	0.95
2	10	9.9e-07	7.2e-05	22.9	0.3	1	23	350	372	350	372	0.99
3	10	0.00021	0.016	15.5	0.4	1	23	375	398	375	398	0.93
4	10	6e-07	4.4e-05	23.5	0.8	2	23	405	426	404	426	0.98
5	10	2.8e-08	2.1e-06	27.7	1.0	1	23	432	454	432	454	0.98
6	10	4.2e-06	0.00031	20.9	0.8	1	23	460	482	460	482	0.99
7	10	0.001	0.074	13.4	3.1	3	23	490	510	488	510	0.98
8	10	0.00086	0.063	13.6	0.3	1	23	516	538	516	538	0.98
9	10	8e-05	0.0058	16.9	3.7	1	23	544	566	544	566	0.99
10	10	0.00092	0.068	13.5	0.1	1	23	572	594	572	594	0.96

Sequence Information

Coding Sequence: ATGGATGTTGACAAAATTTGCCTCACATGTCTCAGCTCCTCGGGTCCCCTGGTGTCCATTTACGATGGGGGATCAGGTAGCTGCCTGGCAGACATGCTGCGTGAATTTACAAAAACAAAGCCTCGGAAGAATGATAACTTGCCGGAGAGGGTATGCCTAGGCTGTCTGAGCGAGATAAACCACTGCTACACGTTTAAGATTAAGTGCGAAAACTCCAGTCGGACACTGAGGCAGCTGTTACCCAACGCATTGCCAGAGGAGCCCGACCCAAAGGTGTCTGCTAAAGTGGCAGTAGACACCGCGGAACAGGGTGTCCAAACGATTGACTGGAAACCAAGCCAATGCACCTCGTCCGTTCAAACTGACGCAGTGTCCACCGCGGAGGCCGAACAGAACACCAGTCTAGAGAAGACGAATTTGCCAGAAGACCTGGATGAAGATGAAGGAGAGGTTTTCGACTATGAGCTAACAGATGTTCCAGAGGAGAAAACACAGAGCATTATCCTTCAATTGCAGGACAGCTTAAAGAACGAGAAAGAAGGGGTGTTTACCCAAACTGATGTAATTTATGAAGGCGACGAGGAACTGGAGCAGCAGATTCGAGAGTGCAACATGGCTATATTCGAGACACCTGACGGTGAGGCGGAGATTGTGGAACTGCCTTCTCCCCAAGTAACCACCAGAAACAGCGCAGCTAAGCTTCAAACCCAGCAGCAAAAGCCAGTTAGGGAAACGTCGGAGAACAAACCAGAAGCTAAGGAAGAGGAACAGCCACAGCCAGCCAAGAGGACCTCACGTCGCAGAGCAGCACCACAGCCGGAGGAGCAAGTGAAGGCACCAACACCAGCAGCCGCTAGTCCAGCAAAACAAATCCGGTTGGGAAGCGCCCGGAAATCCCTGAATTCGGTATCCGTTACCGTTCCAGGAGCAACCGCAGCAACATTAACAGCCGAACTGAAGTACCACTGTGATCGTTGCAATGCGGGTTTCGCGCTGGAAAAGTCGCTGATCATTCACAAGCGCCAGAAGGGCTGCACGAATCGCAATTTCAAGTGTAATGAGTGCGAAAGGGTGTTTGTGTCGCCTGAGCACTTAGCCGAGCATCAGGCTACTCATGGGACGCATACTTGCGCGGAATGCGGGATGCAGTTCGAGTCCAAAGAGCAGCTGGGCAAACACATGGTGCAAGGTCACAAGCGAAACCTGCGTAATCAGTGCAACATTTGCCAAAAGGTCTTCACCATGCTTTCAACCTTACGTGACCACATGCGCATCCATACCGGCGAGAAGCCGTTTGTTTGCAACATTTGCGGCAAGAGCTTCACTCAGAATGCCAACTTGCGGCAGCACAAGCTACGCCACTCGGAGACCAAGAGCTTTAAATGTGATCTGTGCCCGCACTCGTTCGTCACCAAGGCGGAGTTGGCTTCTCATGAACGCACCCACACTGGCGATAAGCCCTTTGGGTGCGATGTGTGCCAGGCAAAATTCACCACCAGCTGTTCTCTGGCCAAGCACAAAAGAAAACACACTGGGGAGCGTCCCTATGCCTGCGACCTTTGCCCCATGAGATTTACGGCCCTGAATGTGCTCAAGAATCATAGAAGAACGCACACTGGTGAGCGGCCGTACGTTTGTCCCTTCTGCTCCAAGACCTTCACTCAACGAGGCGATTGCCAAATGCACCAACGTACCCACCAGGGCGACCGCATCTACATCTGTCCCGTGTGCAACGAAGAGTTCAAGTCAATGCCCGATATGCGATCCCATCTGTCGGAACACGAACAGCATGACAAGCGACTGGTGCATTTCACCCTGCTGAGCAACAAGGAGAACGGTAGTGGAAGTGGTGGTATCGAGGAAGACCTAAACGAAATGGCAGAGACGGCGCTAATGCTGTAA
Protein Sequence: MDVDKICLTCLSSSGPLVSIYDGGSGSCLADMLREFTKTKPRKNDNLPERVCLGCLSEINHCYTFKIKCENSSRTLRQLLPNALPEEPDPKVSAKVAVDTAEQGVQTIDWKPSQCTSSVQTDAVSTAEAEQNTSLEKTNLPEDLDEDEGEVFDYELTDVPEEKTQSIILQLQDSLKNEKEGVFTQTDVIYEGDEELEQQIRECNMAIFETPDGEAEIVELPSPQVTTRNSAAKLQTQQQKPVRETSENKPEAKEEEQPQPAKRTSRRRAAPQPEEQVKAPTPAAASPAKQIRLGSARKSLNSVSVTVPGATAATLTAELKYHCDRCNAGFALEKSLIIHKRQKGCTNRNFKCNECERVFVSPEHLAEHQATHGTHTCAECGMQFESKEQLGKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCDLCPHSFVTKAELASHERTHTGDKPFGCDVCQAKFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGDRIYICPVCNEEFKSMPDMRSHLSEHEQHDKRLVHFTLLSNKENGSGSGGIEEDLNEMAETALML

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00476066;
90% Identity: iTF_00580112;
80% Identity: -