Dmac002330.1
Basic Information
- Insect
- Drosophila maculinotata
- Gene Symbol
- topi
- Assembly
- GCA_035045305.1
- Location
- JAWNPD010000319.1:755845-757259[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 2.4 1.7e+02 3.1 0.9 2 23 156 177 155 177 0.92 2 9 0.00023 0.015 15.8 1.6 1 23 183 207 183 207 0.97 3 9 0.00025 0.017 15.6 4.2 1 23 214 239 214 239 0.96 4 9 5.9e-05 0.004 17.6 1.2 1 23 248 270 248 270 0.97 5 9 0.00048 0.033 14.7 1.9 3 23 280 302 278 302 0.90 6 9 0.00029 0.02 15.4 1.0 1 23 308 330 308 330 0.97 7 9 0.00013 0.0088 16.5 1.4 2 23 337 359 336 359 0.96 8 9 0.00095 0.064 13.8 0.9 1 23 365 387 365 387 0.97 9 9 3.5e-07 2.4e-05 24.6 0.2 2 23 394 415 393 415 0.97
Sequence Information
- Coding Sequence
- ATGACGTCAACAAATAGTTTATCTAGATGCCGAATTTGCATTTGTGCTCTAAGTGCAACTGTTGCCAGCTATGATATGAGAGAATTACCCATGCTGGCCCACAAATTTACCGCCTGTACCGATCTGTCCATTTCGGAGGAGGCTGGAGTTCCAAGTGAGCTGTGCCAGGTGTGCCATGACCAGTTGGAGCATCTGTATGCATTCCGCGCAAAGTGCATTGCAGCCGATACTCAATGGCGTCTGGAGATATTAGAAGACTCCAATTCCAGCTTGGATGAGGCGCTAACTGTGGAAGTCTCGGAGCTGGAGCTAAACACTGCCAAGAAGATTAGCAAAACGCGAGGAAGAAGGCAAGACATAGAAGAAGACACGCCTGAAATAGAATTACCAGGAACAGAAAGCGCACCAAAGGATGCAATACAAAATGAACAGAGTTCACCATCCAAACACACTCCGCCCAGCTTAAAGTGCGACATTTGTGCCATGCGCTTTCTGGTGGAGCATCGCCTCTTGGCGCATAAGCGCCAGCACGAAGGACTCATGCCTTATCCTTGCACTGAGGATGGCTGTGAGCGATCCTTTAATCGTCTGCAGTGTCTGAAGGAGCACCTGAGGCAGCACTCGGGCAACAGCCGCTGGTTCAGCTGCGAGCAGGAGGGCTGCCATAAGATGTATCGCCACAAGCCCACGCTCATGATGCACATGCGCAAGAGCCACAAACTGGGACCGGAGCTCAAGTCGCACGTTTGCGAGTTCTGCGGCAAAGTGTTTAGTACCACGGCGGTGCTCAACGATCACCGCTACACGCACAAGGACAAGTCGGAGTTGCCGCACGCCTGCCTAGAGTCGGACTGCTCGAGACGCTTCTCGAGCAGGGAGAAACTCAAGGTGCACCTGATGCGCCATGCGGGCATCAAGAACTTCAGCTGTCCGTACTGTGGCTTGCGCAAGACGACACGGAATGAGCTGAAGATACACATGAACTATCATACGCTGGAGCGCACCTGGCCCTGCCGCTTCTGCTCGAAGGTGTGCAACAGCTCCGGCAATCTCAAGATGCACGTGCGCACCGTCCACGAGCGTGCCAGGGACTATGCCTGCAGCTACTGCGAGCGCAGCTTCGCCAAGGCGGACACCCGCAAATATCACGAGATGACCCACACCGGCGAGAAGCCCAGCGAGTGCGAGGAATGCGGCAAACGCTTCACTCAGCCAGCGGCATTACGCACCCATCGCAAGATTCATGAGCGACAGCGCAAGCAAATGGAATCCAACTCATCAGTGTATAAGGTTTTGATAACTGATCCAAGTGCTACAGCTGCTGTCAGCGTTGTCCAGTTGGATGGCTGTAGCTAA
- Protein Sequence
- MTSTNSLSRCRICICALSATVASYDMRELPMLAHKFTACTDLSISEEAGVPSELCQVCHDQLEHLYAFRAKCIAADTQWRLEILEDSNSSLDEALTVEVSELELNTAKKISKTRGRRQDIEEDTPEIELPGTESAPKDAIQNEQSSPSKHTPPSLKCDICAMRFLVEHRLLAHKRQHEGLMPYPCTEDGCERSFNRLQCLKEHLRQHSGNSRWFSCEQEGCHKMYRHKPTLMMHMRKSHKLGPELKSHVCEFCGKVFSTTAVLNDHRYTHKDKSELPHACLESDCSRRFSSREKLKVHLMRHAGIKNFSCPYCGLRKTTRNELKIHMNYHTLERTWPCRFCSKVCNSSGNLKMHVRTVHERARDYACSYCERSFAKADTRKYHEMTHTGEKPSECEECGKRFTQPAALRTHRKIHERQRKQMESNSSVYKVLITDPSATAAVSVVQLDGCS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00508529;
- 90% Identity
- -
- 80% Identity
- -