Basic Information

Insect: Drosophila macrospina
Gene Symbol: Cf2
Assembly: GCA_035042075.1
Location: JAWNLW010000267.1:4759853-4763396[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.5 33 5.1 7.9 1 23 80 103 80 103 0.94

2 8 2.1 1.4e+02 3.2 0.1 1 23 132 155 132 155 0.93

3 8 0.92 60 4.3 0.1 1 11 182 192 182 197 0.86

4 8 2.5e-07 1.6e-05 25.0 0.8 1 23 390 412 390 412 0.98

5 8 4.6e-08 3e-06 27.3 2.7 1 23 425 447 425 447 0.99

6 8 4.2e-07 2.7e-05 24.3 1.1 1 23 453 475 453 475 0.98

7 8 4.6e-07 3e-05 24.1 3.5 1 23 481 503 481 503 0.98

8 8 1.5e-07 9.7e-06 25.7 1.4 1 23 509 532 509 532 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.5	33	5.1	7.9	1	23	80	103	80	103	0.94
2	8	2.1	1.4e+02	3.2	0.1	1	23	132	155	132	155	0.93
3	8	0.92	60	4.3	0.1	1	11	182	192	182	197	0.86
4	8	2.5e-07	1.6e-05	25.0	0.8	1	23	390	412	390	412	0.98
5	8	4.6e-08	3e-06	27.3	2.7	1	23	425	447	425	447	0.99
6	8	4.2e-07	2.7e-05	24.3	1.1	1	23	453	475	453	475	0.98
7	8	4.6e-07	3e-05	24.1	3.5	1	23	481	503	481	503	0.98
8	8	1.5e-07	9.7e-06	25.7	1.4	1	23	509	532	509	532	0.96

Sequence Information

Coding Sequence: ATGTTAAAGTCtaccacaaacacacaggAATTGCGTCTGCCACGCCCAGAGGAACaccaacagccacaacagcaggagCATCCAACGCATCAGGTTGCCGCCGTGATAGCCCACAACATTACAACgtctgcaacagcagcaggagctgcagcaACGCCCAGCCACAGCATCAACATGGATACGCTTAAGACAGCTTTTCTGCCCAATCTCAGCATGGATCCGAATGTCATCAGTACGCATTACTGTCCCATGTGCCATCAGCAATTCGAGCGTGCCCAGCATGCGGCTGATCATATGCATCTCTGTCATGGCATCACATTGAATGCCCATGGAACGATTACAACcctcgagcagcagcagcagcaacagcaacaacatttgaaacCGCTAAGCTATGCGTGTGCTAACTGTGATGATAAGTTTGGTAGCGCTCAGGAGGTGGATGAGCACCATCGGTTGGCGCACCAGGCAACGGCATTTTTGGCGCGTTGCATTGTCTGCAGCATTTATGGCGTCAATTCTGTAACGCAGAATCCCAACGAATACAAATGCTCGAATTGTGGTGCTGTCTGTACGGCGGCTATGTTGGCTGCTGGCCAGCAACCGTTTATGGAACACCAGGAGGCGCCGGTGACACCAGATGATCTGCCCGCCATTGCGCCGCGTGATATGAGACTGACGCCAgaagagcagcaacaccagcagcagcaacaacaacaacagcagcagcaacaacagcagcagcagctgcaacaggagcaacaattgcagcagcaacaacagcagcagcagcaacagcagcagcaacaacaacaacaggaacaccATCACCAGCAGCTtgatcaacagcaacaacaggagcaacaacgacaacgtgaactacaagagcaacagcaccaaGACGATTTAAGTGATCCCGGAACGCTGAAGGTGCCGCCGCTTACAGTGAAACTGTTGAAGAACGGCAATGGTGCCACAGTAACACATCCCCAGGTGATCATCAAGGAGGAGCCGCTCAGTTTGAGCGATAGCGGCGATGTTGTGAACGCAGTGCCCGTCTATGCCATACAAGCGAATCCTGGCGTGCAACCGGGAACACCTGGTGCCACAACAAGTGTGCTGGTTAGCACACAAACGGTGCCAGCGGATTTGGCGCATAAGATACGACACAAATGCCCCGATTGCCCCAAAACGTTCAAGACACCCGGCACGTTGGCCATGCACCGCAAGATACACACGGGCGAAGCAGAcgcCACGCCCAAAGAACGCCCCTACACGTGCTCCTACTGCGGCAAGTCCTTCACTCAATCGAATACACTAAAACAGCACACTCGCATACATACAGGTGAGAAACCATTTAGATGTGGCTATTGTGGCAGGGCGTTCACTGTTAAGGATTACCTGAACAAACATTTAACGACTCACACGGGTGAAAAACCGTTTCATTGTGGCTACTGTGAGAAGTCCTTTAGCGTGAAGGACTATCTCACGaaacacatacgcacacacaccggCGAAAAGCCGTACACCTGTCCGTATTGTGACAAACGATTCACGCAACGCAGCGCACTCACCGTGCACACGACAAAGCTGCATCCACTCTAG
Protein Sequence: MLKSTTNTQELRLPRPEEHQQPQQQEHPTHQVAAVIAHNITTSATAAGAAATPSHSINMDTLKTAFLPNLSMDPNVISTHYCPMCHQQFERAQHAADHMHLCHGITLNAHGTITTLEQQQQQQQQHLKPLSYACANCDDKFGSAQEVDEHHRLAHQATAFLARCIVCSIYGVNSVTQNPNEYKCSNCGAVCTAAMLAAGQQPFMEHQEAPVTPDDLPAIAPRDMRLTPEEQQHQQQQQQQQQQQQQQQQLQQEQQLQQQQQQQQQQQQQQQQQEHHHQQLDQQQQQEQQRQRELQEQQHQDDLSDPGTLKVPPLTVKLLKNGNGATVTHPQVIIKEEPLSLSDSGDVVNAVPVYAIQANPGVQPGTPGATTSVLVSTQTVPADLAHKIRHKCPDCPKTFKTPGTLAMHRKIHTGEADATPKERPYTCSYCGKSFTQSNTLKQHTRIHTGEKPFRCGYCGRAFTVKDYLNKHLTTHTGEKPFHCGYCEKSFSVKDYLTKHIRTHTGEKPYTCPYCDKRFTQRSALTVHTTKLHPL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00540527;
90% Identity: iTF_00528998;
80% Identity: -