Basic Information

Insect: Drosophila macrospina
Gene Symbol: zfh1
Assembly: GCA_035042075.1
Location: JAWNLW010000504.1:918156-922511[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.0018 18.5 1.0 1 23 149 171 149 171 0.97

2 15 0.00087 0.057 13.8 1.2 3 23 179 199 177 199 0.94

3 15 5.4e-05 0.0035 17.6 0.1 1 23 358 380 358 380 0.98

4 15 0.00088 0.057 13.8 2.2 1 23 386 408 386 408 0.98

5 15 5.9e-05 0.0039 17.5 4.2 1 23 439 461 439 462 0.95

6 15 0.00063 0.041 14.3 1.9 1 23 497 519 497 519 0.95

7 15 0.0026 0.17 12.4 0.4 1 23 525 548 525 548 0.98

8 15 0.028 1.8 9.1 0.4 3 19 557 573 556 574 0.95

9 15 0.00016 0.011 16.1 5.6 1 23 583 605 583 605 0.97

10 15 0.043 2.8 8.5 1.2 2 23 611 632 610 632 0.96

11 15 9.6e-06 0.00063 20.0 1.0 1 23 641 663 641 663 0.98

12 15 0.0011 0.071 13.5 0.1 3 23 671 691 669 691 0.97

13 15 5.8e-05 0.0038 17.5 0.5 1 23 697 719 697 720 0.95

14 15 0.056 3.6 8.2 0.4 1 23 730 752 730 752 0.97

15 15 0.0031 0.2 12.1 0.1 1 23 1294 1316 1294 1316 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.0018	18.5	1.0	1	23	149	171	149	171	0.97
2	15	0.00087	0.057	13.8	1.2	3	23	179	199	177	199	0.94
3	15	5.4e-05	0.0035	17.6	0.1	1	23	358	380	358	380	0.98
4	15	0.00088	0.057	13.8	2.2	1	23	386	408	386	408	0.98
5	15	5.9e-05	0.0039	17.5	4.2	1	23	439	461	439	462	0.95
6	15	0.00063	0.041	14.3	1.9	1	23	497	519	497	519	0.95
7	15	0.0026	0.17	12.4	0.4	1	23	525	548	525	548	0.98
8	15	0.028	1.8	9.1	0.4	3	19	557	573	556	574	0.95
9	15	0.00016	0.011	16.1	5.6	1	23	583	605	583	605	0.97
10	15	0.043	2.8	8.5	1.2	2	23	611	632	610	632	0.96
11	15	9.6e-06	0.00063	20.0	1.0	1	23	641	663	641	663	0.98
12	15	0.0011	0.071	13.5	0.1	3	23	671	691	669	691	0.97
13	15	5.8e-05	0.0038	17.5	0.5	1	23	697	719	697	720	0.95
14	15	0.056	3.6	8.2	0.4	1	23	730	752	730	752	0.97
15	15	0.0031	0.2	12.1	0.1	1	23	1294	1316	1294	1316	0.97

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCCTCTGCAGTCGACTCCGAGTCAGATATGCTGGAAAACGGCGCTGCCGACAGTGAGGTGACTGCAGCCTATTTGGTGAATGGCAATGCAACCGACGAAGATCTCGACCATATGGCGGCCGAGAATCTCATCTTTATGGCGCGAGATGGTCAGCTGAGTGAGATAATAGCTGCCAACGAATCGGGTGGCGGGACGGTCCTAATCACTGACAGTGGCGTCGCATATGCCGAGTCATTCGATGATGACGCACAAGTGGTCACCGAGGAGATCATCACTGATGATTGGGTGCAGCACCAAGGCGCCGAACGTGTCGAAATCGCTGCAGAGCAAATTGCAGGCAATGCCAATTCGCTGGAGCTACTGGATATGGAGCAGGATGAGTATACGGCACTGCGACCCTATCCGTGTGATTTCTGTAGCCGGCGTTTTCGCAAGAAGGCGAGCCTCAATAACCACATGCTGGCGCATCAAAACGATCGTCCGCATCTGTGTAAATTGTGCGGTGCACGATTCTCGCGACGTGCCGAGCTCATCAGTCACTTTAAGGCGCATGCGGAGGCTCAGGATGCAGCCGATGCTGAggccgcagcggcagcgtcaaTTAAGTTtgagccacagcaacaaagacCAATGGATGATCATTTCTACGAACAGGAGTGGCCACTGTATCAGGACCAGGAGCACGAGCACGAACACATGCAGGAGCAGGGACAACAACTGGACCAGGAGCAGTTAACCGTCGCCAGTCAAGTAGTGCAACAGGCCAGCTATGCGGCAGTAAGCGATGTGCCACCACCAACAGCTGCCCGCGGTCGCATCAGTCGTCTGAAGCCCAAGGAGGAGAGCACTCAGTACATTGTGATTGCTGAGAAACAGACAACGGACGAACTGCAGCAGTTTGTGGACTGTGAGGGTCTAACGCCACAGctgacaacaaatgcaacgtCCACTGATGCCAACAATTCGTTGGACAACGGTCAAAGCATGGATGCATCACGTTTCCCAGTGCTGGATGATAGTAAACCCTTTGTGTGCCAAGAATGTGGTTTGGCATTTGCACGTGAGAAGGCGCTTGTGTCCCATATCAAGAATCATCGCATGGATTCACCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGATAATCACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCAGAGTATGATCCCGCATCGGCGGGTGATGACAGTGCCAGTGAATCGGAGCCAGATCAGCTCTATGGTGACTTCTACTGCAGTGAAtgtggcatttcatttcaccGCCAGGACTTGCTCCGTCGCCATGCCAAGCAGCATCATAAGCTGACCGCGGCATCAACAATCAACGCTGCCGATGTTGAGGTCAGCGCAGATGCGGATGCTGACGGCGATGGGGATGTGGAGAATACCAAAGATGCGCCACACTGTTGTCATACATGTGGCAAATCCTTTCCCAGCGCCCTCGAGTTGCTTGCCCATGCCGAGATTCACGCACGTTTCCCGCCATTCAAATGCGTCCTGTGTGGGATTAGCTTTTACGAGGAGCAGGCCATCAAACGGCATTTGAACACCCGTCATCCGCACGAGCTTAAACCAAATTCATGTGTTCTCTGCGGCAAGGAGTGTCGCGATCGCAAGGCGTTGATCAAGCATGCCTGGGATCATTCGCGCGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAACTTTCACAACAAGGCGCGCCTGAAGCGGCACATGGCCTCGCATCGAGACAAGTCTGTGGTGTGTGAGGTCTGCCACGAGGAGTTCCCCGATGGTCGCACCCTTTCCAATCATCGTCATTCGCATAGCACCACCTCGCCGGGCAAACTGTTCCCCTGCCACGAGTGCGGCAAGACCTTTGGCTCCCGCAGCTCCCAGCAGATCCATGTGCGCATCCATACGGGCGAGCGACCATATGGATGTCGCTATTGCTGGAAGGCGTTTGCCGATGGCGGTACGCTGCGCAAGCATGAAAGGATTCACACTGGCGAGAAGCCATACGCCTGCTCTGTTTGTCCGCGTGCGTTCAATCAGCGGGTCGTGCTGCGGGAGCACATACGATCCCATCATTCGGGTTTGGATGCGGTGCATGGAACGTATCATTGCACCGTCTGCTCGGCGGACTTGTCGTCATCCAATGAGCTGATACAGCATCTCATTCAGCACAGCGACACGAACACAGCCAAACAGCGACAGCCAATTACTGGACCACGCAAGTACAAGCGGCGAAGGAAACTGCAGCCACATGAGATCGCACACATGCGGGCTGAGAACAAGGATGGCGACGATTACGTCAGCGACATGGATCTCTGCGACTTGGATGTGGAAAACGTGGACGATCTCTTTGATACGGCAGAGGCAACGCCGCCCAAAAGGGAAAAGCGCAAACGCAGTGCCCCAAGTCAAGCGAAACCTGCGCCAAATGGTGTCTCAACAAGCAccctaaacaacaacacaacaccaGCAGGGAAATCCACAAATGGGAGTCAGGATCGCATGTGGGAGGAGAAGTTCCTGCAGgcgaatggcaatggcagtgcCGGCAATCAGATAAATGATGATACGTTTAAGAACTTCTTTCAAATTGACTCGTTGGTGGTGGTGAATGATACCACGCTGCAGCCAGTTGGCTCATCCAGTGGCGGCCCAGCAGCCAAGACGCGACGTAGCGGCAAGCCGCAGTCGCAGGCggcgagcaacagcagcagcagcaagtcaacaacgacagctgcagcaacagcagcggcaacaacaggaCAAGATGAGTGCAGCAAGTCCAATGCCTCCATCAGCTCAAGCAGTCGTAGCAACCGTAAGAAGGCTGGCAAGTCATCCAAGAACTCAAGCACAACATCATCCACATCGAGCAGCACACGACCACGCATGATTCACACGGAAAAGTCCCGTTTGCCGCCAGACAGTGGGTCGAAGAAGACACGGGGTAGATCCTATGTGACCAGGACGAGCACCAGCGAGAGCAGTCAGCTGGGACTGGTCAAGTCGAGTGGCGTTGGCAGCTCGCGCATTGTGGATGACTATGAGATAATATCACCTGCCACACAGCCACCGAATCAGATAAGCTCCAGTCCGCTGCACATTaagcaggaacaggagcagcagcagcagcagcgtgtcCCACACATGTACGATGATACGCATCTGTTGATCGATGCGGGGCTGTTGCGTGAGAAGACCTACGAGAAGTTCAATCCCAGCATTGTCAATGATCTCGAGGAGATCTTGCGTAGTCCGCTCAAGCATGATCGCAATGCTCGATTGCGTTTCACCAGCGAATCATCGACAACGCCACAGTTTCTGCCCGAGGAGGAGCAGAATCTGATTAAGATTGAGCCAACGTCGCCGGATTTACGTGAAATGGTCGAGAGTCAGCAGCGTGTGAGCTCCACTGTGCATGCAACCACACCCTCATCATCGTCCTCGTCAGCGGCACGCACCTCACGCCACCTGCGCCAGCTCACTGCCAACTCCAGTTCCAGAGCGGCAGCGAAACgtcactgcagcagcagcaacagcagcggcaacaaaacCATCTCCGCCTCCAGTTCCAAGAAATCCGCATCATCGTCCACATCTGTGGCCGTTAGCAAAGCCAACTCATACCTCAGCTATGGCGTCGATGCCTACAATGTGAATGTGACCACCAATGCCAACACATCGGATGTCAGCTCAGGATTCTTTTCCATCTCCGAGGTCGTGTCCGCCGCTGATGCCGCCGACGCAGCCgccaaagcagcagcggccAACAAACCGGAGCGTCGTGCCCGCTGCTATGAGTGTGAGATGTGCTCGGCCAATTTCCCGGATCGGGCGCAGTTGTTGGAGCATGTGCATATACACATCTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSESDMLENGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDSGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNANSLELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAASIKFEPQQQRPMDDHFYEQEWPLYQDQEHEHEHMQEQGQQLDQEQLTVASQVVQQASYAAVSDVPPPTAARGRISRLKPKEESTQYIVIAEKQTTDELQQFVDCEGLTPQLTTNATSTDANNSLDNGQSMDASRFPVLDDSKPFVCQECGLAFAREKALVSHIKNHRMDSPFECNQCQEMFWDNHSLQEHQKTHQFEESNSEYDPASAGDDSASESEPDQLYGDFYCSECGISFHRQDLLRRHAKQHHKLTAASTINAADVEVSADADADGDGDVENTKDAPHCCHTCGKSFPSALELLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVHGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDGDDYVSDMDLCDLDVENVDDLFDTAEATPPKREKRKRSAPSQAKPAPNGVSTSTLNNNTTPAGKSTNGSQDRMWEEKFLQANGNGSAGNQINDDTFKNFFQIDSLVVVNDTTLQPVGSSSGGPAAKTRRSGKPQSQAASNSSSSKSTTTAAATAAATTGQDECSKSNASISSSSRSNRKKAGKSSKNSSTTSSTSSSTRPRMIHTEKSRLPPDSGSKKTRGRSYVTRTSTSESSQLGLVKSSGVGSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQQRVPHMYDDTHLLIDAGLLREKTYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSSTVHATTPSSSSSSAARTSRHLRQLTANSSSRAAAKRHCSSSNSSGNKTISASSSKKSASSSTSVAVSKANSYLSYGVDAYNVNVTTNANTSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRARCYECEMCSANFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: -
80% Identity: -