Basic Information

Insect: Drosophila lutescens
Gene Symbol: zfh2
Assembly: GCA_037075285.1
Location: JBAMCF010000341.1:443481-460015[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.0001 0.0084 16.8 1.4 2 23 430 452 429 452 0.96

2 10 2.6e-05 0.0021 18.7 0.7 1 23 484 508 484 508 0.92

3 10 0.0045 0.37 11.6 0.4 1 22 607 628 607 631 0.91

4 10 3.4 2.7e+02 2.6 0.4 1 21 772 793 772 794 0.89

5 10 1 82 4.2 1.9 1 23 815 839 815 839 0.91

6 10 0.045 3.6 8.5 0.3 1 23 1087 1110 1087 1110 0.98

7 10 8.5 6.8e+02 1.3 1.4 2 23 1221 1244 1220 1244 0.83

8 10 0.037 3 8.8 0.9 2 21 1318 1337 1317 1341 0.89

9 10 4.9e-05 0.004 17.8 2.3 1 23 1392 1414 1392 1414 0.98

10 10 0.0006 0.049 14.4 1.3 2 23 1421 1443 1420 1443 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.0001	0.0084	16.8	1.4	2	23	430	452	429	452	0.96
2	10	2.6e-05	0.0021	18.7	0.7	1	23	484	508	484	508	0.92
3	10	0.0045	0.37	11.6	0.4	1	22	607	628	607	631	0.91
4	10	3.4	2.7e+02	2.6	0.4	1	21	772	793	772	794	0.89
5	10	1	82	4.2	1.9	1	23	815	839	815	839	0.91
6	10	0.045	3.6	8.5	0.3	1	23	1087	1110	1087	1110	0.98
7	10	8.5	6.8e+02	1.3	1.4	2	23	1221	1244	1220	1244	0.83
8	10	0.037	3	8.8	0.9	2	21	1318	1337	1317	1341	0.89
9	10	4.9e-05	0.004	17.8	2.3	1	23	1392	1414	1392	1414	0.98
10	10	0.0006	0.049	14.4	1.3	2	23	1421	1443	1420	1443	0.94

Sequence Information

Coding Sequence: ATGTCCAGTTCTGATGTGGAAACTTTTAACGGCAAAATAGTTTACAATCTCGATGGCAGTGCATACGTTATCGCCACAGACAATGCCAATGGAAGTGGATCGGGGTCTGCTCAAAGTTGTTATACCCAAACTACGAATTCAGTAAAGAAACTCACAAAGGTGAAAGATCGTGGACAGGGGGAGAAGGAAAAGGAACACCAGCATCAACATCATCAGGGTCAGGGCGAAACACAGGAGCAGGAACTAGCTGATGTGGATGCTGGTCCTGGTGTCGAATCCGTAGCGAGAGCCACCTACAAGTCGAGTCCAAAATTGTCCTTTGGCAACGTCAAGTCCTTCAGTTTGCATGCGAACACCGAACACAGACTCAACTTGGAAGAGCTGGACCAGCAGCTACTTAATCGCGAGTACTCCAGTGCCATTATTCAGCGAAATATGGATGAGAAGCCGCAGATATCCTTTCTACAGCCATTGGATAATAATGCCCCCTGCTCTGCCAGCGATGACACCGAGAAGCTTCAAATAGCCCCCGAGGGCAGTGGCCCCATTCTTCCTCCGTCTCCGCAGCCAGTTCTCGGCAATGAGTCTGAACTGGAGCTGGAGCCCGAGAACAAGCAGGTGGCTGAGCAGGTCCGGGTCCTGGACCAGGGCCGGGAGCAGGAGCCTGAAACTGACCAGGACTCCAGTAGTAGTATAATGGCGGCACCTAATTTTATGCAACTGCAGCATGCGGCGGCCGGTGGCATATACCCTCCTCAAGTCAGTTCCTTCCATGCATCCCTAGCAGCGCTGGCCGCCAATGAATCGAACGACAACCGGGTCAAGCTGATCACAGAGTtcctccagcagcagctgcagcagcatcagcagcagagCTCCCTGTTTCCCAGCCACTGTCCCGACCATCCGGACTTGAACGGTGTGGACTGCAAAACCTGCGAGCTTCTCGACATCCAGCAGCGGTCTAAGTCGCCGCCCTCCTCGCATCAGCATCTATCTCAATCCCTGCCACAGCTTCAGGTTCAGTCGCAGCAACAACCCCAGCAGATACCACATCGTTCTCCTTGCAGCAACAGCGTGGGCCTGGCCATATCGCCCAGTGCATCCTCGGTAGCCAGCGTTGGAAATGCGTCGAGCGCCACTACCAGCTTCACCATCGGCGCCTGTTCCGAGCACATCAATGGTCGTCCCCAAGGAGTGGACTGTGCGCGCTGTGAAATGCTTCTAAACTCGGCTCGATTAAACAGCGGCGTGCAAATGTCTACTCGCAACTCCTGCAAGACTCTCAAGTGTCCGCAATGCAATTGGCACTATAAATACCAGGAGACACTGGAGATCCACATGAGGGAGAAGCATCCAGATGGGGAGAGTGCCTGTGGTTACTGCCTTGCAGGACAACAGCATCCTCGGCTGGCACGGGGGGAATCCTACTCCTGCGGTTATAAGCCGTACCGCTGTGAAATCTGCAACTACTCCACGACCACCAAGGGCAATCTCTCCATCCATATGCAATCGGACAAGCATCTGAACAACATGCAGGAGCTGAACAGCTCCCAAAATATGGTGGCGGCCgcggctgctgcagcagcgacTAGCAAACTGCTGCTCTCGAGCACGTCACCCCAAGGATCTGGTGCGGGCACATCCGGCAGCGGATCCAGCGGTGCCACCGGCTCCTCCGGCTGTGGCGGACCCAACAATGTCGGCGGCACCGCATCACTGGGTGGAAACGCACCGATCGCCGGTGCGGGAGCGGGAGCAAGTAACTCCAATGCCAATGCCGGAAGCAATGCCAACAGCGCCAAGCCAAAGCCCTCGTTTCGGTGCGACATCTGCAGCTATGAGACTTCCGTGGCACGCAACCTGCGCATCCACATGACCAGTGAgaagcacacacacaacatGGCTGTGCTGCAGAACAACATCAAGCACATCCAGGCGTTCAACTTcttgcagcaacagcagcaaggATCCGCTGGCACTGTTCCAGGACACAGCTCCGGGAGCTTTATGCCCGAGGTTGCGTTGGCCGATCTCGCTTATAACCAGGCGCTTATGATACAGCTGCtacaccaacagcaacagcaacaacatcagcagtCGGCTAATACCAAATTATCACCCTCGTCTTCGCCCGTGAGCACACCGGATCAGTTTTCcttctctcccaagccaatgaAGATTGGCCACGGAGCAGGAGTAGGCATGGGCCTGGGGATGCCAATGGGAATGAGCCACTCGAACGAGGTGCCCGGCGACCTGGCTGGCGATCCTCATCCGTTGACGAAAACCGATAAGTGGCCCACGGCGTTCTTCAGCTGTCTAATCTGCGATTGCTTCAGTACGAACAACTTGGATGATCTTAACCAACATTTGCTCGTAGACCGATCTCGGCAATCCTCCAGCGCCTCTTCCGAAATAATGGTTATTCACAATAACAACTATATATGCCGGCTATGCAACTACAAGACGAATCTCAAGGCCAATTTCCAACTGCACAGCAAGACGGACAAGCACTTGCAGAAGCTCAACTTTATCAACCACATCAGGGAGGGCGGCCCCCGTAATGAGTACAAGATGCAGTATCAGCAACAGCTGGCCGCCAATGTGGTGCAAGTGAAGTGCAACTGCTGCGACTTCCACACAAATTCTATTCAGAAGCTGTCCCTGCACACACAGCAGATGCGTCACGACACGATGCGAATGATATTCCAGCACCTACTGTATATTGTTCAGCAGAGCCAAATGCACAAGAAGTCCCCGGGTACGTCGGAAGATGATGCCCAATGCTCCTGTCCGGATGAGGATcagcaatcgcaatcgcagtCCGCCAGGAAACTGCTCCTCTGCCAGCTGTGCAACTTCACCGCCAAAAACCTGCATGATATGGTTCAGCATGTAAAGGGCATGAGGCACATGCAAGTCGAgcaatttatttgcttacAGCGTCGTAGTGAAAACCAGGAAATACCCGCACTGAGCGACGTGTTCAGAGTGACTGAGTGGATCATGGACAACGAAGATATGACTTTCGAGGCGGGCTTTAACTTGTCAAGAACTGCAACCAACGAAGCCACCCCGGATGCCAGCTATGCTACGGCATTATCTGCGTCTGGAGTCTCTGCAATTCCTGACGTCAGTATATTTTCACCGACTTCTCCCTCCAGTTGCGCGACACCATGCGGCAAGCCAGTGGGCCACATTGCATCTCCGGGCCTGAATAACTTTGGCTCGGGCGCCCCTGTTCCTACCACAGTATTCAAGTGCAATCTCTGCGAATACTTCGTTCAATCGAAAAGCGACATTGCGTCTCACATTGAGACCGAGCACCCGTGTGCTGAGAGTGATGACTTTATAAGTATACCAACCAACACAGCCGCTCTGCAGGCTTTCCAAACAGCTGTAGCAGCAGCTGCTCTGGCTGCGGTACAGCAGCGGTGCGCCGCTATTAATGGTCCGACACAGGATGCCGGCGAAGCAGAGAAGGACATGGACaccaatgccaatgccaatgaCGGCCCAGTGGCTATTAAACGGGAGCGGCTTGAGGAGGATGATGATGCCATGGCAGTTATAGAAGATACCAAAGACGTTCCAACTCAGGCGACGTCTTCTGCAGCTCCGCAGTCGCCGAAATATCCGGAAACACAAGTTGGGGTCCAGTGTCCATTGTGCCTGGAAAATCATTTCCGGGAGAAACATTACCTGGAGGCCCATCTGACAAGTGTCCACAGCGTTACCCGAGATGGTCTTTCCCGGCTCTTGCTGCTAGTGGATCAGAAAGCCTGGAAAAACGAAAGTGAGGGCACTGACATTCCAAGCCTACCCCCTCAATCGAATACCAATAAGGAAGAGGCGACGGCAACACCTAGTGAAAGCCCCTCCAGTGCCAACGCAGTCAAGTGCACCACCGCATCTAGCTCTAGCCTTCCAGTGGGAATGCAAGGACTCTCCTGCCAGCAGTGTGAGGCTAGCTTCAAGCACGAGGAACAGCTGCTCCAGCATGCGCAGCAGAACCAGCATTTCTCGTCACAAAATGGAGAGTACTTGTGTCTTGCAGCCAGCCACATCAGCCGACCCTGCTACATGGGCTTCAGAACCATTTCAGCTATGATCAGCCACTTCCAGGACTCACACATGAGCCTAGTTATCTCAGAGCGCCATGTCTACAAGTATCGCTGCAAACAGTGCTCGCTAGCTTTCAAGACTCAAGAAAAGCTCACGACGCACATGCTCTACCACACAATGCGGGATGCTACGAAGTGCTCTCTTTGCCAACGCAACTTTCGCAGCACCCAGGCGCTTCAGAAACACATGGAGCAGGCGCACTCGGAAGATGGTACACCATTAGCCAGGTCAAACAGTCCACAGACGCCGACTTTGAATGCCGAGGAGACACACAAGCATTCTCCACGCGAGACACATGCGCTAGAAGTCCCAGGTAACGATGTGTCACCGCTTCGGTTAGAGGCGCAACTAAGCAAGGAAACTAGGCACTTGTCGCCTAGCCCAATGTCTGCGGATTCCCAGGCCCAGCAGCAATACCTAGCTACTTTCGCAGCTCTGCTCAAGCAACAGCAGGGTAACTCAGAAGCTGTTGGCCTCCACCCCGAAGCCTTGTCGCTGTCCGCTGGAGAATTCTCCCAACACTTACAGGGTCTCCAAAATCTGCAAAGCCTTCAGCATATGCAACAGCAATTTGGTGCCGTAGCTGCCGCATCCGGACTACCGATTAATCCGGTAGATATGCTTAATCTAATGCAGTTTCACCACCTGATGTCATTGAACTTCATGAACCTGGCTCCCCCCTTGGTATTCGGCGCTGGCGCCGCCGGTAGCAACGCCATTCCCGCGTCAACAGCCCAGAATAACAGCATTACCTCCTCCACCGTAGCAACTGCTTCAGGACTAGCTGATGTTCAGCTCACCACGGGAGCTAACGCCATGGCGGTTGACTCTGCTAAAGCTACTATAGTTTCAGCTCAACCTCAGCACAATGTCAACTCAAACCCTCAGCTGGCCAGTAACCAAAAACGAGCCAGAACGCGAATCACGGATGATCAGTTAAAGATTTTGCGGGCTCATTTCGACATAAATAACTCCCCAAGCGAAGAGAGCATTATGGAAATGTCACAGAAAGCAAATCTCCCAATGAAGGTGGTGAAACACTGGTTCCGAAACACCTTGTTTAAGGAAAGACAACGCAATAAGGACTCTCcttataattttaacaatCCACCGTCGACAACTCTTAATTTGGAGGAATATGAACGTACAGGTCAGACCAAGCCCATCCACGACACCAACACCACCCCAACGAGAACGCAGCAACAGTTTGGACCACCCTCAACGACCTCCCAAGTTTGA
Protein Sequence: MSSSDVETFNGKIVYNLDGSAYVIATDNANGSGSGSAQSCYTQTTNSVKKLTKVKDRGQGEKEKEHQHQHHQGQGETQEQELADVDAGPGVESVARATYKSSPKLSFGNVKSFSLHANTEHRLNLEELDQQLLNREYSSAIIQRNMDEKPQISFLQPLDNNAPCSASDDTEKLQIAPEGSGPILPPSPQPVLGNESELELEPENKQVAEQVRVLDQGREQEPETDQDSSSSIMAAPNFMQLQHAAAGGIYPPQVSSFHASLAALAANESNDNRVKLITEFLQQQLQQHQQQSSLFPSHCPDHPDLNGVDCKTCELLDIQQRSKSPPSSHQHLSQSLPQLQVQSQQQPQQIPHRSPCSNSVGLAISPSASSVASVGNASSATTSFTIGACSEHINGRPQGVDCARCEMLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAATSKLLLSSTSPQGSGAGTSGSGSSGATGSSGCGGPNNVGGTASLGGNAPIAGAGAGASNSNANAGSNANSAKPKPSFRCDICSYETSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNFLQQQQQGSAGTVPGHSSGSFMPEVALADLAYNQALMIQLLHQQQQQQHQQSANTKLSPSSSPVSTPDQFSFSPKPMKIGHGAGVGMGLGMPMGMSHSNEVPGDLAGDPHPLTKTDKWPTAFFSCLICDCFSTNNLDDLNQHLLVDRSRQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGPRNEYKMQYQQQLAANVVQVKCNCCDFHTNSIQKLSLHTQQMRHDTMRMIFQHLLYIVQQSQMHKKSPGTSEDDAQCSCPDEDQQSQSQSARKLLLCQLCNFTAKNLHDMVQHVKGMRHMQVEQFICLQRRSENQEIPALSDVFRVTEWIMDNEDMTFEAGFNLSRTATNEATPDASYATALSASGVSAIPDVSIFSPTSPSSCATPCGKPVGHIASPGLNNFGSGAPVPTTVFKCNLCEYFVQSKSDIASHIETEHPCAESDDFISIPTNTAALQAFQTAVAAAALAAVQQRCAAINGPTQDAGEAEKDMDTNANANDGPVAIKRERLEEDDDAMAVIEDTKDVPTQATSSAAPQSPKYPETQVGVQCPLCLENHFREKHYLEAHLTSVHSVTRDGLSRLLLLVDQKAWKNESEGTDIPSLPPQSNTNKEEATATPSESPSSANAVKCTTASSSSLPVGMQGLSCQQCEASFKHEEQLLQHAQQNQHFSSQNGEYLCLAASHISRPCYMGFRTISAMISHFQDSHMSLVISERHVYKYRCKQCSLAFKTQEKLTTHMLYHTMRDATKCSLCQRNFRSTQALQKHMEQAHSEDGTPLARSNSPQTPTLNAEETHKHSPRETHALEVPGNDVSPLRLEAQLSKETRHLSPSPMSADSQAQQQYLATFAALLKQQQGNSEAVGLHPEALSLSAGEFSQHLQGLQNLQSLQHMQQQFGAVAAASGLPINPVDMLNLMQFHHLMSLNFMNLAPPLVFGAGAAGSNAIPASTAQNNSITSSTVATASGLADVQLTTGANAMAVDSAKATIVSAQPQHNVNSNPQLASNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQTKPIHDTNTTPTRTQQQFGPPSTTSQV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00536671;
90% Identity: iTF_00536671;
80% Identity: iTF_00536671;