Basic Information

Insect: Drosophila lowei
Gene Symbol: ush
Assembly: GCA_008121275.1
Location: CM017779.1:18807387-18816271[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0054 0.4 11.1 0.0 1 20 193 212 193 214 0.90

2 9 0.00023 0.017 15.4 0.8 1 23 267 289 267 289 0.98

3 9 0.042 3.1 8.3 1.0 2 21 343 362 343 363 0.92

4 9 0.04 3 8.3 2.9 2 21 714 733 713 734 0.93

5 9 0.0075 0.56 10.6 0.0 3 21 783 801 781 802 0.91

6 9 0.0054 0.4 11.1 0.0 2 23 869 890 868 890 0.98

7 9 0.0032 0.24 11.8 1.3 1 23 896 918 896 918 0.99

8 9 0.00057 0.043 14.2 0.8 1 23 973 996 973 996 0.96

9 9 0.16 12 6.5 0.4 2 20 1105 1123 1104 1125 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0054	0.4	11.1	0.0	1	20	193	212	193	214	0.90
2	9	0.00023	0.017	15.4	0.8	1	23	267	289	267	289	0.98
3	9	0.042	3.1	8.3	1.0	2	21	343	362	343	363	0.92
4	9	0.04	3	8.3	2.9	2	21	714	733	713	734	0.93
5	9	0.0075	0.56	10.6	0.0	3	21	783	801	781	802	0.91
6	9	0.0054	0.4	11.1	0.0	2	23	869	890	868	890	0.98
7	9	0.0032	0.24	11.8	1.3	1	23	896	918	896	918	0.99
8	9	0.00057	0.043	14.2	0.8	1	23	973	996	973	996	0.96
9	9	0.16	12	6.5	0.4	2	20	1105	1123	1104	1125	0.91

Sequence Information

Coding Sequence: ATGATACAGATGAAGAAGATCTTCCACCAGAGGAAACAGAAGATGAAAGCATCCAATTCCAAAGATTTAACCGCTCAGGAGCTGGGCGaagagaaacagcaacagctacagcagcagcagcaggaggatcCAATGGATCTTcaggacaacaacaacaacagcgatgcagatgcagatgcagaggATGCTGTATCCGAACAGCCGGAAGAGACTCAGGATTTAGGGGAAACAGAAATGGACCACCACcaccaggaggaggagaaggagcaggagcacgTGGAGGCAGAAGAGGCTCCGATCAGTCCTACCAGCGACTCCCCATCGGAATCGCCATCGCCCAGTCCTtcacccacgcccacgcccacacccaccGCAACGCCCACTCCGAGGCTACCAAAGCTCCGCCTCAATGCACTGCTCGCCTCGGATCCCGCCCTCAAGCCGGACGCCAAGGAGCTGCATCTGTCGGACAAGCGTCTGCTGGCACCGCCGCCGCACATCAAGCCcgagccgcagccgcagccacagcccccCCTCCAGCCCGATCTCGTGGAGCCGCTGCTGAAGCCGGCGCGATTCATGTGCCTGCCATGCGGCATAGCCTTTAGCTCCCCCTCGACCCTGGAGGCGCACCAGGCTTACTATTGCTCGCATCGGAACAAGGACACGGAGGATGCGGATGGATCCAATGCGGACAAGTCCGGCGGCGGAGAGAAGTCCGCCGCAGGAGGAGCCTCTGGCGGCAGCGGAGGCAGTGGCTCCGAGCCGCCGGCTAAGGTGGCGCGCATCGGGAAGCAGTACGCGTGCACCCAGTGCTCCTACAGTGCCGACAAGAAGGTGTCCCTCAACAGGCACATGCGCATGCACCAGACCTCGCCGGCCCCCAGTCTGGGGAGCCTCGGATCCCTCGGCAGCCTGCCCAGCCTCACGGCGAACGGGGTGCCAGGATCTGCAGGAGTAGTTGGCGCAggcggaggcagcagcagcgccctCGAGGAGGGCTCTAGTCAACAGCAAACCGACCGCTACTGCAGCGACTGTGATATCCGATTCAACAACATCAAGACCTACCGCGCCCACAAGCAGCACTACTGCAGCTCCCGTCGCTCCGACGGCCGTGTGACCCCCAAGGGTGGCTccgaaggagcagcagccgccgccgctcGAGAAGCAGGAGGATCGGTTTCAGCAGGCAGCGCTTCTGCGGCAGCCGCTGCTCCTGGAAAGCTCAGTCCGCAGACACGCAACAAGACGCCCACCCCGGCCATGGTGgctgcagcggcggcggctgcagcagcagcagcagctgctgcctcGCCCACACCCGCTTCGGGGATCGTAAATCTGGAGTCCACCTGCTTCACCGTGGACAATGGGGCCATCAAGCCGCTGGCCACCGCTCTGATCAGCAATGCGCTCGCCGGGAATATGAATCACTTTGTCAATTCCCTGCACATACCCGCCCTGGAGCCGGATCGTCCCACAGCAGGCACAGGCTCAGccgaaggaggaggaggagtccTGGAGCCAAAGAGCAGCAGTCCACCAGAACCCAAGAGGAAGGAGGCTGGAGGCAGTCGTGAATCTGCGCCTCTCGACCTGTCGTTTCGACGATCTCCCATCTCCATCTTGCAGCATCGCCAGCGGCATATCCGGTcagctgccgcagccgcagccgctgctCTGCTGGATGTGGAGGAAGTGCTCCTCGGAGCGGGCAAGGAAAACGTGGAAACTGTCGGCGGAAGAGCTGGAGGCAGTGTGACGCCCGAGCAGATCGTCTGCGCACCCTCCCTGCCCAGCAGCCCGTCGATGAGTCCCTCGCCCAAGCGACGGGCGAGTCCAAGGAGTTCGGGGGCGGGCAGTGCCTCCTCCATGTCGCCGCCTGGCTTGAATCACCATCTGCTGGACATCCGCTCCATGCTGCCAGCGGACTTTGGCCTGTCGGAGTCGCTGCTGGCGAAGACCAATCCAGAGCTGGCCCTCAAGCTggcggctgccgctgcagccgcTGTTGCGGCAGGAGGAAGTGCCTCCTCTTCCGTGGCGGCTGCTCAGGCTGCCTCCAATCCAGGTGGCAATTCTGgcaaccagcagcaacagcagcagccgcagatcTACGTGAAGCAGGGCGTCTCCAAGTGCAAGGAGTGCAACATCGTGTTCTGCAAATACGAGAACTATCTGGCCCACAAGCAGCACTACTGCTCGGCCCGCAACCAGGAGGCTGCCGGCGAGGGCTCCGACTCCAAGTCCGCCGTTTCGCCATCGAATGCCACGGCCGGcaatggtggtggtggcgccTCTAACGTGGAGACCACGCCCGTGGCCTACCAGCAGCTCATCTGTGCCGCCTGCGGCATCAAGTACACCTCGCTGGACAACCTGCGCGCCCACCAGAACTACTACTGCCCCAAGGGTGGGGCCACGGCCGCCACTGCGCCTTCCGAGGCGACGCTGGTGGCCAAGGAGAAGTGCGGCAAGTGCAAGACCCTGCACGATCACGGACACCCCTGCCCGGCGCCCCCCGCTGCCACGCCCCTGACGGCGCCCTCCAGCCTCCAGTCTTCGGCGGGAGCCTCCTCCGGTGTGAACAGCGTCAACAAGTGCCCCGTGTGTGGGGTCGTGAGTCCGACGGCGGCCCTGGCCCGCAAGCACATGGAGATGCATGGGACGGTGAAGGCCTTCCGCTGCAGCATCTGCCAGTACAAGGGCAACACGCTGCGCGGCATGCGCACCCACATCCGCACGCACTTTGACAAGAAGACGAGCGACGTCAACGAGGAGCACTACATGACCTGCATCTTCGAGGAGGATAACTCTGCCCACTCCGCTGTGGCCCAGGAGATGCcccccacagcagcagcagcagcagcagtaccgCAGGAGCCACCGATGGAGCATCCGCCGCAGTTGTTCAACTGCGATTACTGCAACTATGCCTCCACCTACAAGGGCAATGTGCTGCGACACATGAAATTGCTGCATCCGCATGTGGCCATCAATTCGCCCTCGATTTCCCCCGAGTCTCGTGAACAAGAGACTCTTCTTCCGAGCTCCACTCCGAATGCGCACGAAGCGTCCAATGGCGAGGCAGTCAACTTCCACATCAAATCAGAGCCTGGACTGGACAATCCACCGACGCTGGGACTCGTTCACGAGAACAACAACTCGCCCATTGGCACGCCACTGCCGCATATCAAGGCCGAGCCGATGGACATGGGCATCGATGCCATGTCGCCCACATCGCTGGCCCTGCCACCGCCCGTCGCCTCGCCCTTGGCAGCCGCTGCAGCCGAGGCCATGAAGAAGTACTGCTCCGTGTGCGACATATCCTTCAACTACGTGAAGACCTTCCTGGCCCACAAGCAGTTCTACTGCAAGAGCAAGCCCCCACGACCCGAAGTCAACGACAGTCCCAGCCCCAATGCCAATCATCTGGCCggagtgggtgtgggagtgggggtgggcatgggaatgggaggCCAGCCGCTGCAGTCGCCCAGCGAATTGATGCTGATGCAGAAGAACAAGGAGAACCTGCAGGAGGCGGCCATTTGA
Protein Sequence: MIQMKKIFHQRKQKMKASNSKDLTAQELGEEKQQQLQQQQQEDPMDLQDNNNNSDADADAEDAVSEQPEETQDLGETEMDHHHQEEEKEQEHVEAEEAPISPTSDSPSESPSPSPSPTPTPTPTATPTPRLPKLRLNALLASDPALKPDAKELHLSDKRLLAPPPHIKPEPQPQPQPPLQPDLVEPLLKPARFMCLPCGIAFSSPSTLEAHQAYYCSHRNKDTEDADGSNADKSGGGEKSAAGGASGGSGGSGSEPPAKVARIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAPSLGSLGSLGSLPSLTANGVPGSAGVVGAGGGSSSALEEGSSQQQTDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGRVTPKGGSEGAAAAAAREAGGSVSAGSASAAAAAPGKLSPQTRNKTPTPAMVAAAAAAAAAAAAAASPTPASGIVNLESTCFTVDNGAIKPLATALISNALAGNMNHFVNSLHIPALEPDRPTAGTGSAEGGGGVLEPKSSSPPEPKRKEAGGSRESAPLDLSFRRSPISILQHRQRHIRSAAAAAAAALLDVEEVLLGAGKENVETVGGRAGGSVTPEQIVCAPSLPSSPSMSPSPKRRASPRSSGAGSASSMSPPGLNHHLLDIRSMLPADFGLSESLLAKTNPELALKLAAAAAAAVAAGGSASSSVAAAQAASNPGGNSGNQQQQQQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQEAAGEGSDSKSAVSPSNATAGNGGGGASNVETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGATAATAPSEATLVAKEKCGKCKTLHDHGHPCPAPPAATPLTAPSSLQSSAGASSGVNSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDNSAHSAVAQEMPPTAAAAAAVPQEPPMEHPPQLFNCDYCNYASTYKGNVLRHMKLLHPHVAINSPSISPESREQETLLPSSTPNAHEASNGEAVNFHIKSEPGLDNPPTLGLVHENNNSPIGTPLPHIKAEPMDMGIDAMSPTSLALPPPVASPLAAAAAEAMKKYCSVCDISFNYVKTFLAHKQFYCKSKPPRPEVNDSPSPNANHLAGVGVGVGVGMGMGGQPLQSPSELMLMQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00484660;
90% Identity: iTF_00474059;
80% Identity: -